Monopiles for offshore wind turbine foundations are often subjected to vertical-horizontal combined loading. For the analysis of piles subjected to horizontal loads in sand, the p-y curve method based on the Winkler model is usually employed, where p is the soil resistance of the pile per unit length and y is the local horizontal displacement of the pile or the soil compression at the point of study. As the load bearing properties of horizontally loaded piles depend on the ultimate resistance P u of the soil around the pile in the shallow soil layer, it is important to determine P u of the shallow soil accurately. In this paper, the wedge model is employed to calculate P u. The effect of vertical shear stress along the pile on the principal stress direction which decides the bottom angle of the wedge is taken into account. Then, the effects of the vertical loads on the p-y curves, P-Δ effect, M R effect is considered in the horizontal equilibrium equation of the pile. The shear-displacement method is employed to calculated the vertical responses of the pile. The shear stress and horizontal soil resistance were redistributed when the coupled effect of the vertical load and the horizontal load is considered. Then, the horizontal responses of the monopile under vertical load, horizontal load and moment simultaneously can be calculated. Finally, the proposed method is used to calculate a centrifuge model test where a piles is subjected to coupled loads in sandy soils. The results showed that the pile moment curve after considering the bottom angle of the wedge β modification is closer to the experimental results than without the β modification, so it makes the modified β more reasonable in analyzing the behavior of laterally loaded single piles in sand. At the same time, the β modification is not required for pure horizontal loading.