Effect Of Sesame Oil Research Articles

Chitosan/Gelatin/Starch-Based Films Plasticized with Olive Oil and Aloe-Vera Extract as a Potential Wound Dressing

In this study a polymeric film based on chitosan (CS), gelatin (GL) and potato starch (ST) was prepared and the effect of sesame oil (SO) and Aloe-Vera extract (AVE) on the physical and mechanical properties of the control film, as well as its antibacterial activity and cytotoxicity, were investigated. The swelling and water vapor transmission rate (WVTR) results indicated that SO and AVE reduced the amount of swelling and the WVTR of the samples. The mechanical tests showed that SO and AVE, or even any combination of them, had a plasticizing effect on the prepared films. According to the antibacterial results, adding SO or AVE to the film forming solutions had no considerable effect on the antibacterial activity of the sample against E. coli and S. aureus bacteria, while the combination of these two additives to the films made their activity increase. The results of the cytotoxicity tests exhibited the growth of the fibroblast cells after 7 days of incubation, showing that the films containing SO or AVE or the combination of both additives were nontoxic and never caused cell death.

The effect of sesame oil consumption compared to sunflower oil on lipid profile, blood pressure, and anthropometric indices in women with non-alcoholic fatty liver disease: a randomized double-blind controlled trial

BackgroundNon-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the world. There is strong evidence that dyslipidemia and other cardio-metabolic disorders are highly prevalent in patients with NAFLD. This trial aimed at examining the effect of sesame oil (SO) in the context of a weight loss program on lipid profile, blood pressure, and anthropometric indices in women with NAFLD.MethodsThis randomized, double-blind, controlled trial was carried out on 60 women with NAFLD. Subjects were randomly assigned to the SO group (n = 30) and sunflower oil (SFO) group (n = 30), each person consuming 30 g of oil per day for 12 weeks. All the participants received a hypocaloric diet (− 500 kcal/day) during the study. Lipid profile, blood pressure, and anthropometric indices were assessed at pre- and post-intervention phases.ResultsIn total, 53 participants completed the study. Following 12 weeks of intervention, anthropometric indices (p < 0.001) and systolic blood pressure (SBP) (p < 0.05) were significantly decreased in both groups and diastolic blood pressure (DBP) was significantly decreased in So group (p = 0.03). There was no significant change in lipid profile in both groups (p > 0.05). After adjusting for confounders, DBP (p = 0.031) and total cholesterol (TC) divided by high-density lipoprotein cholesterol (HDL-C) (p = 0.039) in the SO group were significantly reduced compared to the SFO group (p < 0.05).ConclusionsThe present clinical trial revealed that SO and SFO may not differently affect anthropometric indices, SBP, and lipid profile except for TC/HDL-C. In addition, SO may be effective in improvement of DBP and TC/HDL-C compared to the SFO group.Trial registrationEthical approval of this trial was obtained at Isfahan University of Medical Sciences with the reference number of IR.MUI.RESEARCH.REC.1399.548 (https://ethics.research.ac.ir/ProposalCertificateEn.php?id=158942&Print=true&NoPrintHeader=true&NoPrintFooter=true&NoPrintPageBorder=true&LetterPrint=true), and it was registered before the start of the patient recruitment on December 12th, 2020 in the Iranian Registry of Clinical Trials (IRCT) with the registration number of IRCT20140208016529N6.

Comparative effects of sesame oil and clove oil on growth performance, blood profile and immunity of rabbit (Oryctolagus cuniculus)

Comparative effects of sesame oil and clove oil on growth performance, blood profile and immunity of rabbit (Oryctolagus cuniculus)

Effect of Topical Sesame Oil on the Severity of Pain in Patients With Limb Trauma: A Randomized Controlled Trial

ObjectiveThe purpose of this study was to investigate the effect of topical use of sesame oil on pain severity in patients with limb trauma. MethodsA placebo-controlled randomized controlled trial was conducted on 120 patients with nonpenetrating upper and lower limb traumas admitted to the trauma emergency department. The patients were allocated to either the sesame oil group or the placebo group using the stratified random sampling technique based on trauma size and age. Depending on the trauma area, sesame or placebo oil were poured on the trauma site and massaged for 5 to 7 minutes. The intervention was repeated twice a day for 3 days at home. Pain severity was measured using the numeric pain scale before intervention on the first day and 30 minutes after each intervention for 3 days, twice a day. Data were analyzed using descriptive and analytical tests including the independent t test, χ2 test, Fisher exact test, Mann-Whitney U test, Friedman test, and multiple linear regression analysis. The significance level was set at 0.05. ResultsThe decreasing trend of pain was significant in both the intervention and placebo groups (P < .001). Comparison of the trend of changes in pain scores between the 2 groups showed that the mean changes of pain severity were higher in the intervention group compared with the placebo group in all assessments. There was a significant difference in the rate of analgesic consumption in the intervention group compared with the placebo group (P < .001). However, there was no significant difference between the 2 groups regarding pain severity. Pain reduction was negatively associated with body mass index (b = –0.091, P = .003), amount of received pain medication (b = –0.001, P = .039), and area of trauma (b = –0.002, P = .039). Pain reduction was greater in male patients than female patients (b = 0.676, P = .015). The effect of sesame oil on pain changes was not significant. No adverse side effects were reported. ConclusionThis study showed that despite less use of analgesics in the intervention group than in the placebo group, sesame oil did not have any statistically significant effects on the severity of limb trauma pain. Further research is needed regarding the effect of topical sesame oil application on pain as a safe and uncomplicated intervention.

Effect of sesame oil on some blood parameters and antioxidants in ovariectomized female white rats

This study was conducted to find out the physiological effect of sesame seed oil (Sesamum indicum) in the case of oral treatment on post-menopause and the occurrence of surgical menopause as a result of the removal of the ovaries, by studying the changes in some blood parameters and some antioxidants in the serum of adult female rat pupae. White (Albino Rats), 15 adult rats about three months old, with weights ranging between 160-180 g, were used. The animals were randomly divided into three groups, five animals per group. The first group represented the negative control, which was normal without removing the ovaries, the second represented the positive control in which the ovaries were completely removed, and the third group had the ovaries completely removed and treated orally with sesame oil at a concentration of 4 ml/kg of body weight per day for a period of 30 days.

Impact of Sesamum indicum oil on the heamatologycal parametrers on albino mice

The current study was conducted to find out the effect of sesame oil on white female rats by studying some biochemical parameters that included vitamin D, parathyroid hormone and calcium ion. The study included 35 animals divided into two main groups divided into groups, each group included 5 animals dosed with different doses 0.5'0.8' 1 ml. The period of dosing was for a month between one day and one day. After the end of the experiment, the animals were sacrificed and the serum was obtained. A significant increase in the volume of vitamin D (13.21±0.312, 16.01± 0.51, 19.51±0.78) (ng/dl) respectively compared with control group (9.739±0.096) (ng/dl) and a decrease in parathyroid hormone (0.101± 0. 001, 0.086± 0. 002 , 0.074± 0.002) (ng/dl) respectively compared with control group (0. 112± 0.002) (ng/dl), which caused an increase in calcium ion (9.85±0.206, 10.948±0.178, 12.62±0.158) mg/dL respectively compared with control group (8.7±0.063) mg/dL, was shown.

Synergistic Effect of Sesame Oil on Chlorantraniliprole Toxicity and Detoxifying Enzymes Activity against Fall Armyworm, Spodoptera frugiperda (J.E. Smith)

The present study aimed to investigate the toxicity and synergistic effect of binary mixtures containing chlorantraniliprole and sesame oil at different ratios against second and third instar larvae of fall armyworm (FAW), Spodoptera frugiperda. The toxicity of different concentrations (LC25 and LC50) of chlorantraniliprole with or without sesame oil (1, 2.5 and 5 per cent) on second and third instar larvae of FAW was determined using the leaf discdip bioassay method. A combination of chlorantraniliprole LC50 plus sesame oil 2.5 per cent has resulted in 74.42 and 81.81 per cent larval mortality on the second and third instars larvae of FAW, respectively. The mortality percentage was 1.52 and 1.57 fold higher than the single effect for the second and third instars of FAW, respectively. These results showed that this combination exhibited high potentiating synergism in both the instars of FAW larvae under laboratory conditions. The activity of Carboxyl Esterase (CarE), Mixed Function Oxidase (MFO) and Glutathione-STransferase (GST) were found to be lesser in chlorantraniliprole LC50 plus sesame oil 2.5 per cent combinations than in single toxicity treatments. Therefore, sesame oil showed good synergism with chlorantraniliprole at the ratio of chlorantraniliprole LC50 plus sesame oil 2.5 per cent on fall armyworm under laboratory conditions.

Effect of Sesame oil and Homogenization Pressure on the Physicochemical, Qualitative and Microbial Characteristics of Yogurt

Effect of Sesame oil and Homogenization Pressure on the Physicochemical, Qualitative and Microbial Characteristics of Yogurt

Insecticidal Activity of Cyperus rotundus L. and Datura stramonium L. Co-Administered with Sesame Oil Against African Bollworm Helicoverpa armigera Hübner (Lepidoptera: Noctuidae)

African bollwormis a worldwide-spread species that shows a high degree of polyphagia and it is considered as one of the main agricultural pests in the world. Laboratory experiments were conducted in the Research Laboratory, College of Agricultural Studies, Sudan University of Science and Technology to evaluate the lethal effect of C. rotundusand D. stramonium on the H. armigeraand to investigate the synergistic effect of sesame oil and tested extracts by dipping methods. Five concentrations (4%, 6%, 8%, 10% and 12%) were used for each plant extract in a Completely Randomized Design. Tubers ethanolic extract of C. rotundus at 12% concentration caused 90% mortality after 72 hrs of application, whereas 12% concentration of seeds ethanolic extract of D. stramonium generate only 70% mortality after 72 hrs of exposure. When sesame oil was added to each concentration of ethanolic extract of C. rotundus and D. stramonium it exhibited a synergistic effect. In fact, the 10% concentration scored 53.3% and 76.7% mortality, however, when mixed with sesame oil the mortality increased significantly to 83.3% and 100% for D. stramonium and C. rotundus respectively after 72 hrs of exposure. This study clearly demonstrates that both tested plants have a lethal effect on the larvae of the African bollworm. However, tubers ethanolic extract of C. rotundus seems to be significantly more toxic than the seeds ethanolic extract of D. stramonium. This study also revealed that sesame oil has a synergistic effect when added to these plant extracts.

Formulation and Evaluation of Ketoprofen Gel Preparations, Sesami Oil Soybean Oil and Oleic Acid as Enhancers

Permeation is a measurable profile in drug penetration in skin. Adding increasing permeation substance (enhancer) in drug formulation is an important thing in pharmaceutical and toxicology in nowadays. The purpose of this research was to evaluate the effect of sesame oil, soybean oil, and oleic acid as enhancer in ketoprofen gel permeation. Six formula were prepared by varying concentration of sesame oil, soybean oil, and oleic acid respectively 5% and 10% and one blank, without enhancer. Permeation test was evaluated by in vitro permeation test using Franz diffusion cell method and shed snake skin of reticulated python as a membrane. Permeation test were carried out for 6 hours. The result showed that sesame oil, soybean oil, and oleic acid were able to increase ketoprofen permeation. B1 formula that contain 5% sesame oil had greatest percent permeation after 6 hours is 5.913%, while blank that contain no enhancer is 0.623%.Keywords: ketoprofen, permeation, enhancer, soybean oil, sesame oil, oleic acid.

The alleviating effects of sesame oil on diazinon-induced toxicity in male wistar rats

Pesticides are introduced into the environment in a variety of ways and constitute a wide group of environmental pollutants. To evaluate the attenuating effects of sesame oil on the toxicity of diazinon (DZN), male Wistar rats were exposed to DZN and/or sesame oil by gavage at different dosages for 8 weeks. DZN in a concentration of 30 mg/kg caused an increase in the number of white blood cell (WBCs), and the combination of DZN and sesame oil raised the number of platelets; the number of red blood cells, however, did not change. In addition, DZN caused a drastic decrease in the sperm count in a dose-dependent manner and in a concentration of 50 mg/kg, the sperm count decreased by more than 50%, but the combination of sesame oil in a dose of 4 ml/kg with DZN reversed the effect of this pesticide. The evidence presented here suggests that in addition to antioxidants, such as olive oil, intermittent exposure with sufficient intervals can decrease the toxicity of pesticides.

The Effect of Sesame Oil and Cucurbita on Healing Wounds Caused by Third-Degree Burn

Background: Previous in vitro studies showed that sesame oil stimulates fibroblast production in wounds. Many studies investigated the therapeutic wound healing properties of natural products. The current study aimed at evaluating the effect of the combination of sesame oil and Cucurbita as a novel herbal mixture on healing the local wounds caused by the third- degree burn. Methods: The current experimental study was conducted on 24 adult BALB/c mice randomly divided into experimental groups. Then, all mice were sacrificed and a sample of wound bed was provided and fixed in formalin, followed by the practical histologic process. The samples were stained with the Mallory-Trichrome technique and investigated under microscopy. A Part of the sample was frozen to extract protein, perform malondialdehyde (MDA) test, and measure total antioxidant. Results: A complete tightening of the wound and less scar was observed in the macroscopic observation of burn wounds in the group treated with sesame oil and pumpkin (treatment group 5) compared with the control and other groups. In the microscopic assessments, a significant increase (P < 0.05) was observed in the total thickness of skin, and number and diameter of the hair follicles in the experimental group compared with other groups. Conclusions: The current study results showed that a combination of sesame oil and pumpkin at different concentrations accelerated the healing process of burn wounds in BALB/c mice, while using the under study materials separately had less effects on the improvement of skin wounds compared with the combination form.

Inhibition of the lipogenesis in liver and adipose tissue of diet-induced obese C57BL/6 mice by feeding oleic acid-rich sesame oil

The effects of sesame oil (SO) on lipogenic gene expression and lipid metabolism were observed. One percent of SO was added into the high-fat diet (HFD) used to feed C57BL/6 male mice for 8 weeks. SO significantly lowered adipose tissue mass than that of the high-fat control group. In addition, serum and hepatic lipid contents were markedly lower than those of the high-fat control group. Especially, the ratio of HDL/LDL was much higher than that of the HFD group. The gene expression of key lipogenic enzymes, Ppar-γ, Srebp-1c, Scd-1, Fas, Acc, Lpl, and malic enzyme, was significantly downregulated in the liver and adipose tissue of mice fed sesame oil. This study suggests that high proportion of oleic acid in SO might be strongly associated with lowering serum and hepatic lipid profile and suppressing lipogenic gene expression.

Topical Application of Sesame Oil for the Prevention of Chemotherapy- Induced Oral Mucositis: Pilot Study in Seven Hematopoietic Cancer Patients

Oral mucositis is one of the most uncomfortable and common complications of chemotherapy. Inflammation which is initiated by release of free radicals from oral mucosal tissue exposed to anticancer drug is involved in the development of oral mucositis. Therefore, it is expected that antioxidant and anti-inflammatory effect of sesame oil may be effective for the prevention of chemotherapy-induced oral mucositis. In the present study, effects of topical application of sesame oil on the chemotherapy-induced oral mucositis were evaluated.

The effects of sesame oil on the prevention of amiodarone-induced phlebitis

The effects of sesame oil on the prevention of amiodarone-induced phlebitis

Antioxidants and tumor necrosis factor alpha-inhibiting activity of sesame oil against doxorubicin-induced cardiotoxicity

Oxidative stress is currently considered to be the key factor in doxorubicin-induced cardiotoxicity. Comparatively small quantity of the endogenous antioxidant content of the heart is assumed to be the predisposing factor for doxorubicin-induced cardiotoxicity. The present research was designed to evaluate the antioxidant potential and tumor necrosis factor alpha-(TNF-α) inhibiting activity of sesame oil against acute doxorubicin-induced cardiotoxicity. Male Wistar albino rats (180-200 g) were administered sesame oil in two dissimilar doses (5 and 10 ml/kg body weight, orally) for 30 days, followed by a single dose of doxorubicin (30 mg/kg s.c.). In the doxorubicin-treated group, increased oxidative stress was proven by a significant rise of thiobarbituric acid reactive substances level and a decrease of myocardial superoxide dismutase, catalase and reduced glutathione content. Histopathological studies showed myocardial necrosis with accumulation of inflammatory cells, vacuolization and overall enlargement of the myocardium. Western blot analysis showed marked expression of TNF-α in the myocardium. Alteration in biochemical parameters by doxorubicin administration was prevented significantly (p < 0.0001) in the 5 and 10 ml/kg sesame oil treated rat hearts. Treatment with 5 and 10 ml/kg of sesame oil reduced the doxorubicin-induced TNF-α expression in the myocardium, which was associated with reduced myocyte injury. The overall effect of sesame oil was comparable with probucol, which shows similar protection. The chronic oral administration of sesame oil prevents acute doxorubicin-induced cardiotoxicity by enhancing cardiac endogenous antioxidants and decreasing myocardial TNF-α expression.

Sesame oil protects against hepatic injury via the inhibition of neutrophil activation in thioacetamide-treated rats

Thioacetamide (TAA) is a potent hepatotoxicant in acute and chronic hepatic injury. The study examined the protective effect of sesame oil against TAA-induced hepatic injury in rats. Hepatic injury was induced by intraperitoneal injection of 100 mg/kg of TAA for 24 h. Triple doses of sesame oil (1, 2, or 4 mL/kg) was given orally 0, 6, and 12 h after TAA treatment. TAA significantly increased serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Sesame oil decreased serum AST and ALT levels and significantly inhibited hepatic lipid peroxidation and nitric oxide levels compared with TAA-alone group. Further, sesame oil significantly inhibited TAA-induced hepatic neutrophil activation marker myeloperoxidase activity. However, sesame oil did not affect hepatic tumor necrosis factor, IL-1β and IL-10 generation in TAA-treated group. In conclusion, sesame oil protects against TAA-induced hepatic injury and oxidative stress via the inhibition of neutrophil activation. However, inflamm...

Sesame oil enhances endogenous antioxidants in ischemic myocardium of rat

The present study was designed to evaluate the potency of antioxidant activity of sesame oil in-vitro model of myocardial ischemic reperfusion injury of rat. Sesame oil was administered orally to Wistar albino rats (180-200 g) in two different doses (n=6), by gastric gavage at a dose of 5 mL/kg b.w. (S1) and 10 mL/kg b.w (S2) daily for thirty days. Control and sesame oil treated rat hearts were subjected to invitro global ischemic reperfusion injury (5 min perfusion, 9 min noflow and 12 min reperfusion). A significant rise in TBARS and decrease of GSH, catalase, LDH, CK and AST occurred in the hearts subjected to in-vitro myocardial ischemic reperfusion injury indicate the myocardial damage through oxidative stress. In sesame oil treated rats there was a significant decrease in TBARS and significant increase in endogenous antioxidants and myocardial marker enzymes in all the groups. In 10 mL/kg treatment group, a significant rise in the levels of GSH, SOD and catalase were observed with marker enzymes, and it shows better recovery profile than the other groups subjected to in-vitro ischemic reperfusion injury. In histological studies, control rats which subjected to IR injury show extensive myocardial damage and all the treatment groups, shows preserved myocardium. The effect of sesame oil was compared with reference compound captopril. The present study demonstrates that the sesame oil treated by the dose 10 mL/kg augments endogenous antioxidant compounds of the rat heart and also prevents the myocardium from in-vitro model of myocardial ischemic reperfusion injury

Protective effects of sesame oil on 4-NQO-induced oxidative DNA damage and lipid peroxidation in rats

Sesame oil could be considered as a potent antioxidant and dietary supplement. It possesses antimutagenic, anti-inflammatory and anti-cardiac toxicity. In the view of available findings, the current study focused on determining the protective effects of sesame oil on 4-Nitroquinoline-1-oxide (4-NQO) -induced oxidative DNA damage and lipid peroxidation (LPO) in rats. Seven groups of Wistar albino rats each with 6 either sex were used. Groups were given vehicle control and sesame oil alone orally and 4-NQO (30 mg/kg) by intraperitoneal injection. Following the four dose levels (1, 2, 4, and 8 ml/kg orally), sesame oil plus 4-NQO were also tested. After 24 hours of 4-NQO injection, blood samples were drawn by venipuncture. DNA damage (8-hydroxy-2-deoxy guanosine; 8-OHdG) and LPO were estimated. LPO from the 4-NQO-treated group was 2.5-fold higher than that of the control LPO. Pretreatment with sesame oil reduced this by 16–61%. 8-OHdG DNA damage from 4-NQO was found to be 3-fold higher than that of controls. Pretreatment with sesame oil effectively protected against DNA damage in a dose-dependent fashion. This study indicates that the antioxidant, sesame oil, effectively protected DNA damage and LPO induced by 4-NQO.

Anti‐Rancidity Effects of Sesame and Rice Bran Oils on Canola Oil During Deep Frying

AbstractIn this study, the effect of sesame oil (SEO) and rice bran oil (RBO) on the rancidity of canola oil (CAO) during the process of frying potato pieces at 180 °C was investigated. The SEO and RBO were added to the CAO at levels of 3 and 6%. Frying stability of the oil samples during the frying process was measured on the basis of total polar compounds (TPC) content, conjugated diene value (CDV), acid value (AV), and carbonyl value (CV). In general, frying stability of the CAO significantly (P &lt; 0.05) improved in the presence of the SEO and RBO. The positive effect of the SEO on the stability of the CAO was more than that of the RBO. Increasing the amounts of SEO and RBO from 3 to 6% led to decreases in the TPC and AV, and increases in the CDV and CV of the CAO during the frying process. The best frying performance for the CAO was obtained by use of 3% of both SEO and RBO together (CAO/SEO/RBO, 94:3:3 w/w/w).