Concrete-filled round-ended steel tubes (CFRTs) are a unique type of composite stub columns, which have the advantage of aesthetics and a well-distributed major–minor axis. Thus, the structure has been widely employed as piers and columns in bridges. To improve the mechanical performance of CFRTs with a large length–width ratio and to enhance the restraint effect of steel tubes on concrete, this study investigates the compressive property of multi-chamber, concrete-filled, round-ended steel tubular (M-CFRT) stub columns using a combination of experimental and numerical analyses. A detailed compression test on eight specimens is conducted to examine the compressive property of M-CFRT stub columns. The study focuses on understanding the influence of some key parameters on ultimate bearing capacity, failure stage, damage modes, and ductility. Additionally, the accuracy of the finite element modeling method in simulating the ultimate bearing capacity of the structure is verified. Finally, the calculating formula for the ultimate bearing capacity of M-CFRT stub columns is proposed on the basis of the experimental and numerical findings. Results of the formula calculation are consistent with the experimental data. These research findings serve as a valuable reference for designing similar structures in engineering practice.