The article highlights the positive experience with the use of the drug ranolazine as part of the complex treatment of coronary heart disease with rhythm or conduction disturbances. The problem of rhythm and conduction disturbances on the background of ischemic heart disease is one of the most relevant at present. The mechanisms of occurrence of rhythm and conduction disorders in this nosology have not been studied enough. The most likely underlying mechanism is ischemic.Purpose – the goal is to assess the effect of ranolazine on rhythm and conduc tion disturbances with an established diagnosis of IHD.Results. The article discusses various clinical situations in which a reduction in the number of rhythm and conduction disturbances (paroxysms of supraventricular tachycardia / tachyarrhythmias, supraventricular and ventricular extrasystoles), restoration of intraventricular and atrioventricular conductivity has been achieved. The effect was achieved when ranolazine was added to the standard treatment complex. The control was carried out using repeated registrations of the electrocardiogram (ECG), daily monitoring of ECG (SMECG). The dosage of ranolazine was 500 mg twice a day, followed by an increase to 1000 mg 2 times a day.Findings. The clinical examples show a positive result when prescribing ranolazine for the treatment of ranolazine against the background of standard therapy for CHD. Its effect on rhythm disturbances (decrease in the number of supraventricular tachycardias / tachyarrhythmias and supraventricular extrasystoles, decrease in the number of ventricular extrasystoles) and conductivity (restoration of atrioventricular (AV) and supraventricular conductivity) are noted.