Effect Of Q10 Supplementation Research Articles

The Effect of Q10 Supplementation on Lipid and DNA Degradation Indices Following an Acute Physical Activity

Background and Objectives The use of antioxidant supplements improves and reduces oxidative stress factors following intense intense exercise. Exhaustion was performed in female athletes. Subjects and Methods 14 female athletes with an age range of 20 to 28 years and a maximum oxygen consumption of 42-52 m/kg/min in a quasi-experimental design randomly divided into two groups receiving coenzyme Q10 supplementation and placebo (5 mg/kg body weight). Were. After 14 days of coenzyme Q10 supplementation, the subjects performed an intense, debilitating activity. Urine samples were collected in three stages (baseline, before and 24 hours after exhaustive activity) to determine the concentration of 8-OHdG and MDA. Results There was a significant difference of 62% in the increasing response of urinaryOHdG-8 to an exhausting aerobic exercise session (P = 0.003). However, the 2% difference in the increasing urinary MDA response of the supplement and placebo groups was not significant after the last quasi-competitive aerobic training session (P = 0.7). Conclusion According to the results of the study, two weeks of high-pressure aerobic training causes DNA damage and lipid peroxidation in female athletes, and supplementation with Q10 helps prevent the 8-OHdG response of female athletes after a strenuous high-pressure aerobic training session and reduces DNA damage. Become athlete

Effect of Q10 supplementation on exercise-induced response of leukocytes, hepatic damage and anti-inflammatory indicators in male runners

Background: Occurrence of cellular damage in various tissues of the body and inflammatory response is evident during intense sporting competitions, such as half-endurance running racing. Therefore, the aim of this study was to determining the effect of acute and 14-day Coenzyme Q10 supplementation on inflammatory, anti-inflammatory, muscle and hepatic damage indicators response in elite male runners. Methods: In quasi-experimental study, eighteen elite male middle-distance runners (aged 20.45±2.48 years, and body fat 7.4 ±1.63 % and VO2max 60.85 ± 3.96) in a randomized and double-blind design were allocated in two equal groups: supplement group (n=9, Coenzyme Q10: 5 mg/kg/day) and placebo group (n=9, Dextrose: 5 mg/kg/day). Before and after supplementation acute and 14-day period, all subjects were participated in a training like running a competitive 3000 meters. Leukocyte count, serum Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) and interleukin-10 (IL-10) concentration were analyzed before and after two like competitive running 3000 meters and supplementation protocols. Data were analyzed by repeated measure ANOVA, Bonferroni and independent t test, with a <0.05 significance level. Results: The short-term coenzyme Q10 supplementation attenuated the exercise-induced increase in response of ALT and AST and Leukocyte count (p<0.05). However, acute supplementation had no significant effect on any of the parameters. Also, short-term supplementation had no significant effect on baseline and exercise-induced response of IL-10. Conclusion: Based on the results, Short-term supplementation of coenzyme Q10 may reduce markers of liver damage and muscle response to competitive and exhaustive exercise.

Effect of Q10 supplementation on tissue Q10 levels and adenine nucleotide catabolism during high-intensity exercise.

The aim of the present study was to investigate the concentration of ubiquinone-10 (Q10), at rest, in human skeletal muscle and blood plasma before and after a period of high-intensity training with or without Q10 supplementation. Another aim was to explore whether adenine nucleotide catabolism, lipid peroxidation, and mitochondrial function were affected by Q10 treatment. Seventeen young healthy men were assigned to either a control (placebo) or Q10-supplementation (120 mg/day) group. Q10 supplementation resulted in a significantly higher plasma Q10/total cholesterol level on Days 11 and 20 compared with Day 1. There was no significant change in the concentration of Q10 in skeletal muscle or in isolated skeletal muscle mitochondria in either group. Plasma hypoxanthine and uric acid concentrations increased markedly after each exercise test session in both groups. After the training period, the postexercise increase in plasma hypoxanthine was markedly reduced in both groups, but the response was partially reversed after the recovery period. It was concluded that Q10 supplementation increases the concentration of Q10 in plasma but not in skeletal muscle.