Effects Of Prenatal Anxiety Research Articles

The effect of prenatal anxiety on prenatal attachment in high-risk pregnant women and related factors: a cross-sectional study

ABSTRACT High-risk pregnant women experience stress and anxiety. Anxiety may affect prenatal attachment. This study aimed to examine the effect of anxiety on prenatal attachment in high-risk pregnant women. The study was cross-sectional and conducted on 290 high-risk pregnant women who applied to the perinatology outpatient clinic of a university hospital between February and July 2022. The data were collected with the descriptive information sheet, Prenatal Attachment Inventory (PAI), and Perinatal Anxiety Screening Scale (PASS). Mann-Whitney U, Kruskal Wallis-H, and Spearman’s Correlation tests were used to analyze the data. The mean age of the examined pregnant women was 28.12 ± 5.36, and most of them were multigravida (65.5 percent) and in the third trimester (80.7 percent). The PAI and PASS mean scores were 64.09 ± 11.31 and 27.98 ± 16.52, respectively. There was a weak positive correlation between anxiety and prenatal attachment (r = .227, p < .001). The levels of prenatal attachment were higher in primigravidas and women with no children. Also, the anxiety levels of pregnant women in the third trimester were lower. Health professionals should evaluate the prenatal attachment and anxiety levels of high-risk pregnant women, and consider obstetrical factors that may influence both prenatal attachment and anxiety levels.

Prenatal psychiatric symptoms as predictors of postnatal anxiety and depression among primary and multi-gravida women.

The study aimed to examine effect of prenatal anxiety and depression on the prediction of postnatal anxiety and depression among pregnant women. In addition, to find out mean differences in prenatal and postnatal anxiety and depression among primary and multigravida pregnant women. This study was conducted at Sargodha Pakistan, on a total number of 100 pregnant women as participants. The sample size was calculated by using sampling adequacy test which confirmed that the sample of 100 was sufficient to carry out the statistical analysis for the present study. Data was collected by administering Edinburgh Postnatal Depression Scale. SPSS-23 was used for data analysis. The study has been completed in one year, from October, 2017 to November, 2018. Results indicated prenatal anxiety has significant positive correlation with prenatal depression (p< .001), postnatal anxiety (p< .001) and postnatal depression (p< .001). The prenatal depression has significant positive correlation with postnatal anxiety (p< .001) and postnatal depression (p< .001). Results also indicated that postnatal anxiety has significant positive correlation with postnatal depression (p< .001). In this study, findings suggested that there is significant relationship between prenatal and postnatal psychiatric symptoms.

Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: effects on internalizing symptoms from 4 to 15 years of age.

Multiple behavioral and health outcomes, including internalizing symptoms, may be predicted from prenatal maternal anxiety, depression, or stress. However, not all children are affected, and those that are can be affected in different ways. Here we test the hypothesis that the effects of prenatal anxiety are moderated by genetic variation in the child's brain-derived neurotrophic factor (BDNF) gene, using the Avon Longitudinal Study of Parents and Children population cohort. Internalizing symptoms were assessed from 4 to 13 years of age using the Strengths and Difficulties Questionnaire (n = 8,584); a clinical interview with the adolescents was conducted at age 15 years (n = 4,704). Obstetric and psychosocial risk and postnatal maternal symptoms were included as covariates. Results show that prenatal maternal anxiety predicted internalizing symptoms, including with the diagnostic assessment at 15 years. There was a main effect of two BDNF polymorphisms (rs6265 [val66met] and rs11030104) on internalizing symptoms up to age 13. There was also genetic moderation of the prenatal anxiety effect by different BDNF polymorphisms (rs11030121 and rs7124442), although significant effects were limited to preadolescence. The findings suggest a role for BDNF gene-environment interactions in individual vulnerability to the effects of prenatal anxiety on child internalizing symptoms.

The persisting effect of maternal mood in pregnancy on childhood psychopathology

Developmental or fetal programming has emerged as a major model for understanding the early and persisting effects of prenatal exposures on the health and development of the child and adult. We leverage the power of a 14-year prospective study to examine the persisting effects of prenatal anxiety, a key candidate in the developmental programming model, on symptoms of behavioral and emotional problems across five occasions of measurement from age 4 to 13 years. The study is based on the Avon Longitudinal Study of Parents and Children cohort, a prospective, longitudinal study of a large community sample in the west of England (n = 7,944). Potential confounders included psychosocial and obstetric risk, postnatal maternal mood, paternal pre- and postnatal mood, and parenting. Results indicated that maternal prenatal anxiety predicted persistently higher behavioral and emotional symptoms across childhood with no diminishment of effect into adolescence. Elevated prenatal anxiety (top 15%) was associated with a twofold increase in risk of a probable child mental disorder, 12.31% compared with 6.83%, after allowing for confounders. Results were similar with prenatal depression. These analyses provide some of the strongest evidence to date that prenatal maternal mood has a direct and persisting effect on her child's psychiatric symptoms and support an in utero programming hypothesis.

Prenatal maternal anxiety predicts reduced adaptive immunity in infants.

Prenatal anxiety has been linked with altered immune function in offspring in animal studies, but the relevance for human health is unknown. We examined prenatal maternal anxiety as a predictor of adaptive immunity in infants at 2 and 6 months of age as part of a prospective longitudinal study. The humoral immune response to hepatitis B vaccine was assessed at 2 months (n=80) and 6 months (n=76) of age. Prenatal anxiety predicted lower hepatitis B antibody titers at 6 months of age independent of obstetric and socio-demographic covariates; the effects were limited to those infants who had not completed the 3-dose vaccine series (for transformed titer values, r=-.36, p<.05). Cell-mediated immune responses at 2 (n=56) and 6 (n=54) months of age were examined by ELISpot assays for interferon(IFN)-γ, interleukin(IL)-2, and IL-4 responder cell frequencies to three antigens: hepatitis B surface antigen, tetanus toxoid, and phytohaemagglutinin (PHA). Prenatal maternal anxiety was associated with reduced IFN-γ and increased IL-4 responder cell frequencies at 6 months of age, independent of obstetric and socio-demographic covariates. No effect of prenatal anxiety was found on adaptive immunity at 2 months of age. The findings provide the first demonstration in humans that prenatal anxiety alters adaptive immunity in the infant.

Prenatal anxiety and its influence on delivery outcome

To investigate the factors related to prenatal anxiety, to observe the effect of prenatal anxiety on the mode of delivery, intrapartum hemorrhage, and to determine the correlation between prenatal anxiety and delivery outcome. A total of 300 pregnant women were randomly enrolled from 3 hospitals of Changsha, China. The instruments of this survey were self-designed general information questionnaire, state-trait anxiety inventory (STAI), pregnancy pressure scale, and social support rating scale (SSRS). The delivery outcome was observed. The STAI showed that the state anxiety score of the pregnant women was 43.58±10.79, which was significantly higher than that of usual models (P<0.01). Multiple linear regression analysis showed that those factors, such as the item 2 of pregnancy pressure, relationship with mother-in-law, number of abortions, prenatal health condition, times of attending classes for pregnant women, psychological preparation for childbirth, relationship with mother, relationship with husband, item 3 and item 1 of pregnancy pressure, were all related to prenatal anxiety. The anxiety level between the non-indicative cesarean section group and the normal labor group had statistical difference (P<0.01). Intrapartum hemorrhage of cesarean section in the anxiety group had significant difference compared with the non-anxiety group (P<0.01). Some factors have contributed to the anxiety level of the pregnant, such as psychological stress, relationship with mother-in-law, number of abortions, prenatal health conditions, times of attending classes for pregnant women, psychological preparation for childbirth, relationship with mother, and relationship with husband. Prenatal anxiety may lead to increased the rate of non-indicative cesarean section and intrapartum hemorrhage during the cesarean section.