Drug powder explosions pose a potential threat to the process safety of pharmaceutical companies in the processing and storage of products. To explore a reasonable and efficient technology to prevent and mitigate the explosion of combustible drug dust, an experimental system of vertical combustion pipeline equipped with a partial suppression device was built, and the performance of N2 and CO2 loaded with hydrophobic SiO2 encapsulated SiO2 gel (HSESG) respectively to synergistically suppress the explosion of acetaminophen powder was investigated. The results demonstrated that N2/HSESG and CO2/HSESG were effective in reducing the flame average velocity (Vavg), maximum velocity (Vmax), velocity to the top of the pipe (Vtop), and maximum flame temperature (Tmax). N2 loaded with 60 wt% HSESG reduced the Vmax, Vavg, and Vtop of the explosion flame by 68.1%, 66.7%, and 81.3%, respectively, and Tmax by 58.7%. Acetaminophen dust explosion could be completely suppressed by CO2/40 wt% HSESG with 83.7%, 73.0%, and 85.7% decrease in Vmax, Vavg, and Vtop values, respectively, and 80.7% decline in Tmax. The results of thermal decomposition tests and residues characterization indicated that the partial suppression of N2/HSESG and CO2/HSESG was mainly accomplished through the synergistic interaction among thermodynamic, kinetic, and non-homogeneous chemical effects. Subsequently, the reason for the more pronounced suppression effect under the impact of CO2/HSESG was further explained.
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