Prevalence of work-related musculoskeletal disorders (WRMSDs) among dentists and orthodontists is approximated to range between 64%-93%. Etiology of WRMSDs in the mentally and physical demanding occupation remains unclear, for which reason aim of the study was to clarify the interplay of physical, psychological, and mental factors on WRMSDs Material and Methods: Of 94 orthodontists and 187 dentists, (Mage=35 years) questioned using an online-survey, 84% reported persisting tension or pain in the back, neck, or shoulders. While 71% of females were employed (29% self-employed), solely 39% of male participants were employed. Cluster analysis was used to characterize dentists according to their movement profile and the moderating effect of stress on WRMSDs scrutinized. Three movement profiles of dentists and orthodontists were significantly predictive of WRMDS. The minority could be characterized as healthy (n=45), whereas twice as many reported nearly twice as much pain (n=90). Stress proved to be a strong, significant moderator of WRMDs in relation to gender, employment status, and BMI. Prevalence of WRMSDs found in this study is alarming. Given the feminization of dentistry the being a female, stressed and an employee (rather than self-employed) a significant predictor of WRMSDs represents a serious danger to the German health system.