Effects Of Moderate Aerobic Exercise Research Articles

Moderate Aerobic Exercise in College Students’ Memory Retention

This study was conducted to determine the effect of moderate aerobic exercise on memory retention of 1st-year Political Science students at the University of Cebu Main- Campus, Academic Year 2022-2023. It utilized the quantitative research method; thus, this study used a quasi-experimental pre-test and post-test design. The researchers used this design in conducting this study to evaluate if the intervention known as moderate aerobic exercise, precisely the brisk walk-in-place exercise, positively affects the students' memory retention. Moreover, this research design helps determine the effect of the treatment on the respondents before and after manipulation. Physical exercise has undeniably positive effects on both our bodies and minds. The scientific literature emphasizes its impact on our memory. The idea that something as simple as exercise, which anyone can do, has the potential to improve our memory is reason enough to investigate further. This will be especially beneficial for students, as having a good memory is a requirement for academic success. They chose them as the respondents in this study because their major requires much memorization, and they recently switched from online to face-to-face classes. This research aims to see if there is a difference in students' memory retention before and after moderate aerobic exercise. The research was motivated by the recognized positive influence of physical exercise on memory. It focused on its relevance to students who require strong memorization skills for academic success, especially considering the transition from online to in-person classes. The primary objective was to examine any variations in memory retention before and after moderate aerobic exercise. Individuals were given the challenge of memorizing 50 pairs of words within a ten-minute time frame. This task was repeated on the second, third, and fourth days, and a memory retention test was administered on the fifth day. While the overall results did not reveal a significant difference in memory recall, some participants showed modest improvements, suggesting potential benefits for certain students. The study recommends that future investigations consider factors such as IQ levels, learning preferences, diet, sleep duration, and life stressors, which could influence students' memory abilities.

Aerobic exercise and metformin on intermuscular adipose tissue (IMAT): insights from multimodal MRI and histological changes in prediabetic rats

BackgroundPhysical exercise is the first-line intervention for prediabetes, and metformin is the most widely used oral insulin-sensitizing agent. Moreover, intermuscular adipose tissue (IMAT) directly affects insulin resistance by helping maintain glucose homeostasis. Here, we evaluated the effects of moderate aerobic exercise and/or metformin on histological IMAT parameters in non-streptozotocin-induced prediabetes.MethodsMale Wistar rats with prediabetes fed a high-fat diet and high-sugar drinks were randomly assigned to high-fat diet (PRE), metformin (MET), moderate aerobic exercise (EXE), combined therapy (EMC), or EMC + compound-c (EMA) groups for 4 weeks. Multimodal magnetic resonance imaging (MRI) was then performed, and tissue-specific inflammation and energy and lipid metabolism were evaluated in IMAT.ResultsThe EXE group had lower inflammatory factor levels, lipid metabolism, and mitochondrial oxidative stress, and shorter IMAT adipocyte diameters than the MET group. The MET group exhibited lower IL-1β and Plin5 expression than the PRE group. Furthermore, the IMAT of the EMC group had lower TNF-α and phosphorylated NF-κB levels and higher GLUT1 and GLUT4 expression than the PRE group. Multimodal MRI revealed significant changes in transverse-relaxation time 2, apparent diffusion coefficient, and fractional anisotropy values in the IMAT and muscles, as well as lower IMAT% values in the EXE and EMC groups than in the MET and PRE groups.ConclusionModerate aerobic exercise training can effectively improve IMAT function and structure via the AMP-activated protein kinase pathway in prediabetes. Combining metformin with moderate aerobic exercise might elicit modest synergy, and metformin does not counterbalance the beneficial effects of exercise.

The effect of moderate aerobic exercise on the composition of endometrial NK cells in women with idiopathic Recurrent Pregnancy Loss

The effect of moderate aerobic exercise on the composition of endometrial NK cells in women with idiopathic Recurrent Pregnancy Loss

Arterial and Intracranial Hypotension During and Following Exercise

Exercise induced arterial hypertension and post-exercise arterial hypotension (PEH) are well-described phenomena with direct impact on cerebral blood flow. Cerebral perfusion pressure is given by the difference between mean arterial pressure at brain-level (MAPbrain) and intracranial pressure (ICP), however, little is known about effects of moderate aerobic exercise on ICP. We hypothesize that moderate exercise does not increase ICP thereby facilitating the augmented cerebral blood flow and that a post-exercise decrease in ICP is a contributing mechanism to maintained cerebral blood flow during PEH.Non-invasive (N=14) and invasive (N=3) ICP recordings and cardiovascular parameters were measured upright and supine before, during, and after 30 minutes of seated moderate aerobic bicycle exercise. Exercise elevated MAPbrain from 68±4 to 82±7 mmHg (mean±SEM, P<0.05) without elevating ICP, thus increasing CPP (72±3 to 87±6 mmHg, P<0.05). Compared to before exercise, we found significant PEH with a decrease in MAPbrain of 5±3% (5 mmHg; P<0.05), predominantly driven by a 26±5% (P<0.0001) decrease in total peripheral resistance (TPR). Because post-exercise ICP decreased concomitantly by 58±20% (P<0.0001) CPP remained unchanged. Recovery of ICP towards baseline was similarly correlated to TPR-recovery (R2=0.92, P<0.001), all variables returned to baseline within one hour.Here, we show for the first time ICP during and following aerobic exercise and consequences for cerebral perfusion. Periodic PEH is cardio-vascular protective and has long-term benefits for hypertensive patients, here we suggest that post-exercise decreases in ICP could similarly be cerebo-protective and in part explain the long-term beneficial effects of exercise for cerebral health and cognition. This work was supported by NASA grant no 80NSSC19K0020 and the Novo Nordic Foundation grant no NNF15OC0019196 This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Aerobic Exercise Modulates Visceral Adipose Tissue of Estrogen Deprived Rats in an Experimental Model of Dyslipidemia

Abstract Introduction Menopausal women have an increase deposition of body fat and changes in the lipid profile, being especially susceptible to cardiovascular diseases, and type 2 diabetes. However, physical activity can mitigate this situation. Thus, the aim of the present study is to evaluate the effects of moderate aerobic exercise on visceral adipose tissue (VAT) of female LDL-receptor knockout ovariectomized mice. Methods We used 48 animals, divided into six groups (n = 8/per group): sedentary control (SC), sedentary ovariectomized control (SCO), trained ovariectomized control (TCO), sedentary non-ovariectomized LDL-receptor knockout (KS), sedentary ovariectomized LDL-receptor knockout (KOS), and trained LDL-receptor knockout ovariectomized (KOT). We analyzed the VAT through morphometric and stereological parameters in hematoxylin and eosin stained sections. Additionally, we evaluated biochemical parameters as glucose, triglycerides, and total cholesterol. Finally, immunohistochemical techniques for matrix remodeling, inflammation, apoptosis, and oxidative stress were evaluated. Results We observed that menopause is related to increased visceral adiposity, inflammation, oxidative stress, macrophages activity, serum levels of glucose, triglycerides, and total cholesterol. However, exercise was effective in reducing these parameters, as well as being associated with increased vascularization of VAT and interstitial volume density. Conclusions Moderate exercise is a key factor in mitigating the effects of dyslipidemia in estrogen deprivation. However, further studies are needed to corroborate with our findings.

Designed acute physical activity to benefit primary school children’s cognition: Effects of cognitive challenge, bout duration and positive affect

Designed acute physical activity to benefit primary school children’s cognition: Effects of cognitive challenge, bout duration and positive affect

APERFEIÇOAMENTO POR DIETA E PRÁTICA DO EXERCÍCIO AERÓBICO EM ATLETAS PROFISSIONAIS

ABSTRACT Introduction: Body weight regulation in sports competitions is an essential factor affecting the physical capacity of athletes. Especially in high-level events, the role of weight loss is significant in improving the competitive status. Weightlifters have high anaerobic capacity, high aerobic capacity, high flexibility, and less body fat. In all regular competitions, weightlifters compete against competitors of the same weight class. Objective: This paper investigates the effect of moderate aerobic exercise on weight loss in athletes and the effects of related biochemical parameters. Methods: Twenty weightlifters were randomly selected to conduct a questionnaire survey. The athletes performed aerobic exercises for eight weeks. The collection method and mathematical statistics were used to study body shape and constitution, blood indices, and other relevant data about weightlifters in China. Results: The effect of aerobic exercise on improving the athletes' physical fitness is discussed. The results showed that body weight, waist circumference, hip circumference, and body mass index decreased the most (P<0.05). Waist-to-hip ratio, waist-to-height ratio, hip-to-height ratio, and BMI significantly decreased (P<0.05). There was no significant change in height and fat index (P>0.05). Conclusion: 8 weeks of aerobic exercise and an appropriate diet can significantly improve the body shape index, physical index, and biochemical index of athletes. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

Effects of moderate aerobic exercise, low-level laser therapy, or their combination on muscles pathology, oxidative stress and irisin levels in the mdx mouse model of Duchenne muscular dystrophy.

This study aimed to investigate how the combined use of low-level laser therapy (LLLT) and exercise, to reduce the possible side effects and/or increase the benefits of exercise, would affect oxidative stress, utrophin, irisin peptide, and skeletal, diaphragmatic, and cardiac muscle pathologies. In our study, 20 mdx mice were divided into four groups. Groups; sedentary and placebo LLLT (SC), sedentary and LLLT (SL), 30-min swimming exercise (Ex), and 30-min swimming exercise and LLLT (ExL). After 8weeks of swimming exercise, muscle tests, biochemically; oxidative stress index (OSI), utrophin and irisin levels were measured. Skeletal, diaphragmatic and cardiac muscle histopathological scores, skeletal and cardiac muscle myocyte diameters were determined under the light and electron microscope. While only irisin levels were increased in group SL compared to SC, it was determined that OSI, heart muscle histopathological scores decreased and irisin levels increased in both exercise groups (p < 0.05). In addition, in the ExL group, an increase in rotarod and utrophin levels, and a decrease in muscle and diaphragm muscle histopathological scores were observed (p < 0.05). It was determined that the application of swimming exercise in the mdx mouse model increased the irisin level in the skeletal muscle, while reducing the OSI, degeneration in the heart muscle, inflammation and cardiopathy. When LLLT was applied in addition to exercise, muscle strength, skeletal muscle utrophin levels increased, and skeletal and diaphragmatic muscle degeneration and inflammation decreased. In addition, it was determined that only LLLT application increased the level of skeletal muscle irisin.

Effect of Moderate Aerobic Exercise on Complement Activation Pathways in Polycystic Ovary Syndrome Women.

BackgroundThe complement system is pivotal in host defense mechanisms, protecting against pathogenic infection by regulating inflammation and cell immunity. Complement-related protein activation occurs through three distinct pathways: classical, alternative, and lectin-dependent pathways, which are regulated by cascades of multiple proteins. Complement activation is recognized in polycystic ovary syndrome (PCOS) to be associated with obesity and insulin sensitivity. Exercise reduces insulin resistance and may help reduce obesity, and therefore, this study was undertaken to determine the effect of exercise on the activation of complement-related proteins in PCOS and control women.Subjects and MeasurementsIn this study, 10 controls and 11 PCOS subjects who were age- and weight-matched underwent an 8-week supervised exercise program at 60% maximal oxygen consumption. Weight was unchanged though insulin sensitivity was increased in PCOS subjects and controls. Fasting baseline and post-exercise samples were collected and 14 complement-related proteins belonging to classical, alternative, and lectin-dependent pathways were measured.ResultsBaseline levels of complement C4b and complement C3b/iC3b were higher in PCOS (P < 0.05) compared with controls. Exercise reduced complement C1q (P < 0.05), C3 (P < 0.001), C4 (P < 0.01), factor B (P < 0.01), factor H (P < 0.01), and properdin (P < 0.05) in controls, but not in PCOS women.ConclusionExercise induced complement changes in controls that were not seen in PCOS subjects, suggesting that these pathways remain dysregulated even in the presence of improved insulin sensitivity and not improved by moderate aerobic exercise.Clinical Trial RegistrationISRCTN registry, ISRCTN42448814.

Moderate aerobic exercise, but not dietary prebiotic fibre, attenuates losses to mechanical property integrity of tail tendons in a rat model of diet-induced obesity

The purpose of this study was to investigate the alterations with obesity, and the effects of moderate aerobic exercise or prebiotic dietary-fibre supplementation on the mechanical and biochemical properties of the tail tendon in a rat model of high-fat/high-sucrose (HFS) diet-induced obesity. Thirty-two male Sprague-Dawley rats were randomized to chow (n = 8) or HFS (n = 24) diets. After 12-weeks, the HFS fed rats were further randomized into sedentary (HFS sedentary, n = 8), exercise (HFS + E, n = 8) or prebiotic fibre supplementation (HFS + F, n = 8) groups. After another 12-weeks, rats were sacrificed, and one tail tendon was isolated and tested. Stress-relaxation and stretch-to-failure tests were performed to determine mechanical properties (peak, steady-state, yield and failure stresses, Young’s modulus, and yield and failure strains) of the tendons. The hydroxyproline content was also analyzed. The HFS sedentary and HFS + F groups had higher final body masses and fat percentages compared to the chow and HFS + E groups. Yield strain was reduced in the HFS sedentary rats compared to the chow rats. Peak and steady-state stresses, failure strain, Young’s modulus, and hydroxyproline content were not different across groups. Although the HFS + E group showed higher failure stress, yield stress, and yield strain compared to the HFS sedentary group, HFS + F animals did not produce differences in the properties of the tail tendon compared to the HFS sedentary group. These results indicate that exposure to a HFS diet led to a reduction in the yield strain of the tail tendon and aerobic exercise, but not fibre supplementation, attenuated these diet-related alterations to tendon integrity.

Moderate intensity aerobic exercise effects on the quality of life and general health

Objective: Effects of regular physical activity on the human health is an important factor for the life quality parameters. The present study aimed to determine effects of moderate aerobic exercise on the life quality and human health. Materials and Methods: There were three groups (competitive cyclists, recreational cyclists and control) who voluntarily participated in this study. The cyclists of the National Bicycle Federation who could continue trainings during the Corona virus pandemic (n: 50), cyclists of the amateur clubs (n: 50) and 50 sedentary adults (≥19 years) were enrolled (n:150). World Health Organization Quality of Life Questionnaire Abbreviated Version - WHOQOL-BREF-TR was used to determine participants' life qualities. Results: Competitive cyclists trained for 13.33 (±7.24) hours per week and they had 4798 min/week MET values. Subgroup scores of WHQOL-BREF-TR (physical, psychological, social, environmental, national environment, general life quality and health) were found to be higher in competitive cyclists than others (recreational cyclists and sedentary adults). In addition, the values of competitive and amateur cyclists in the physical health level parameters were higher than the control group. Competitive cyclists had higher scores for psychological, social health and general life quality subgroups than others (p&lt;0.05). Conclusion: The present study showed that if physical activity level increases, general health status and life quality increase. As a result of the study, it was found that moderate-intensity aerobic exercise (2600-4800 MET-min/week energy expenditure) between 7-13 hours a week supports the protection of general health and has positive effects on life quality. There is a need for future research to determine different exercise types, intensity, frequency and their effects on the general health status and life quality.

Effect of moderate aerobic exercises on symptoms of functional dyspepsia.

Functional dyspepsia (FD) is a commonly encountered entity worldwide and is difficult to treat. Most of the treatment modalities have low-quality evidence for use, except for proton pump inhibitors. Aerobic exercise has been shown to improve the symptoms, but its direct effect on symptoms has never been studied. The objective was to study the effects of moderate aerobic exercise on symptoms of FD and to compare the effect of conventional treatment alone vs. exercise plus conventional treatment. Out of 112 patients, 72 were randomly divided into controls (conventional treatment;n=36) and experimental (aerobic exercise for 30 min per session, 5 times a week for 6 weeks with conventional treatment; n=36) groups. Both thegroups were assessed on day 1 and at the end of 6 weeks, using Glasgow Dyspepsia Severity Score (GDSS), Depression Anxiety Stress Scales-42 (DASS-42), and visual analogue scale (VAS). Pre-treatment GDSS, DASS-42, and VAS in the experimental group were significantly different as compared to the post-treatment scores (p=0.00019, p=0.0002, p=0.00019, respectively). Even in the control group, pre- and post-treatment GDSS, DASS-42, and VAS scores were significantly different (p=0.00019, p=0.0002, p=0.00019, respectively). However, on the head-to-head comparison of the 2 groups, scores at the end of 6 weeks were significantly different (p< 0.05), in favor of the experimental group. Aerobic exercise as an auxiliary therapy to conventional treatment has better outcomes in the functional well-being of dyspepsia.

Effect of Moderate Aerobic Exercise on Serum Levels of FGF21 and Fetuin A in Women with Type 2 Diabetes

Effect of Moderate Aerobic Exercise on Serum Levels of FGF21 and Fetuin A in Women with Type 2 Diabetes

Effects of moderate aerobic exercise on thoracic aortic remodeling of female LDL-receptor knockout ovariectomized mice

Menopause is a major factor involved in dyslipidemia increasing the risk of atherosclerosis which may be reversed by a routine of aerobic physical activity. Thus, this study aimed to analyze the effects of aerobic training on the thoracic aorta of female LDL-receptor knockout mice submitted to estrogen deprivation. Fifteen genetically modified female mice, knockout for the low-density lipoprotein receptor (LDL-Knockout group) were used as experimental groups and fifteen wild female mice (C57BL/6 J) were used as control groups. Animals were divided as (n = 5/per group): sedentary control (SC); sedentary control ovariectomized (SCO); trained control ovariectomized (TCO); LDL-Knockout sedentary (KS); LDL-Knockout sedentary ovariectomized (KOS); and LDL-Knockout trained ovariectomized (KOT). Immunohistochemical techniques for TIMP-1 and metalloproteinases 2 and 9 were used to evaluate thoracic aorta remodeling. Picrosirius stain was used to highlight the collagen fibers. Verhoff-Van Gienson was used for the quantitative analyses of elastic lamellae. Our results demonstrate a positive remodeling promoted by physical exercise in ovariectomized and dyslipidemic animals. However, further studies are needed including the evaluation of inflammatory markers present in dyslipidemia.

Effect of Moderate Aerobic Exercises on Liver Function in Non-Alcoholic Fatty Liver Disease in University Students

Effect of Moderate Aerobic Exercises on Liver Function in Non-Alcoholic Fatty Liver Disease in University Students

Investigating the protective effect of aerobic exercise on oxidative stress and histological damages of testicular tissue associated with chlorpyrifos in male rats.

The current study aimed to investigate the protective effects of moderate aerobic exercise against chlorpyrifos (CPF)-induced testes dysfunction. In excremental study, 48 adult male albino rats were randomly allocated into 16 groups of 3 rats each. Twelve experimental groups received intraperitoneal injection (5days a week) of either 1.0 or 3.0mg/kg body weight CPF in DMSO for 2, 4 or 6 consecutive weeks. Seven of these experimental groups were subjected to run at moderate exercise intensity for 5days per week over 2weeks, whereas the other groups were not. Two groups (sham groups) were administered to the equal volume of vehicle (DMSO) for 4 or 6 consecutive weeks. The remaining two groups comprised the control groups including a sedentary and an exercise-trained control group. Exercise training leads to a markedly increase in testicular superoxide dismutase (SOD) activity in CPF-exposed rats compared with corresponding sedentary animals (p<.05). Lipid peroxidation level was found to be significantly decreased in the testis of exercised animals that had been exposed to CPF (p<.05). Our results suggest that aerobic exercise can alleviate the oxidative stress induced by sub-acute CPF exposure in testis. Exercise training could barely mitigate CPF-induced testicular damages in rats.

Efficacy of the Moderate Intensity Aerobic training on Heart Rate Variability (HRV) in Patients with the Type-2 Diabetic Neuropathy

Background: Cardiac autonomic neuropathy (CAN) is a common diabetes complication. Damage of the autonomic nerves distributed in the heart and blood vessels in patients with diabetes may result in CAN and increase their risk of death. Therefore, CAN prevention is of considerable important for these patients. The purpose of this study was to determine the effect of moderate aerobic exercise on heart rate variability (HRV) in type 2 diabetic neuropathy patients. Methods: In this quasi-experimental clinical trial study, 23 men with diabetic neuropathy were randomly placed at two groups: aerobic training (n=11) and control (n=12). Aerobic training was accomplished for 12 weeks (3 sessions per week, intensity 50%-80% of the reserved heart rate, duration of each session 25-45 min). Heart rate variability of patients was recorded for 20 min at rest and in the supine position before and after 12 weeks of aerobic training. Results: In aerobic training group, time domain parameters contains SDNN and rMSSD were significantly increased after exercise compared to pre test values. Also in frequency domain parameters, HF was significantly increased and LF/HF ratio was significantly decreased. But in LF parameter was not observed any significantly different. In the control group was not significantly change in time domain and frequency domain parameters. Analysis of inter -group differences showed that changes in all time domain and frequency-domain parameters values (except for the LF Power parameter) in the exercise groups were significantly different from those in the control group. Conclusion: It seems that moderate intensity aerobic training improved the function of the cardiac autonomic system and hence, improved cardiac rhythm and eventually increased HRV in diabetic neuropathy patients.

Postexercise Intracranial Hypotension

Arterial hypotension, minutes to hours after exercise, is a well described phenomenon. The drop in mean arterial blood pressure (MAP) likely results from a combination of sustained vasodilation of the previously active muscles, centrally mediated reduction in sympathetic nervous activity and resetting of thermo-, chemo-, and baroreceptors. Despite decreased MAP, cerebral blood flow is generally well maintained. PURPOSE: To characterize effects of moderate aerobic exercise on intracranial pressure (ICP) as a mechanism for maintaining cerebral perfusion pressure during and following exercise. METHODS: Sixteen healthy volunteers completed 30-min exercise at 70% estimated VO2-max on an upright ergonomic bicycle followed by a one-hour recovery phase in supine position. MAP, heart rate, stroke volume, and total peripheral resistance (TPR) were recorded continuously (Nexfin). In 15 subjects (8 female, 20±2 years, height 169±10 cm, weight 64±12 kg) ICP was estimated non-invasively by evoked tympanic membrane displacement (Cerebral Cochlea Fluid Pressure device). Invasive parenchymal ICP recordings were performed in one, cerebrally intact, former patient (male, 74 years, 176 cm, 80 kg) via a permanently implanted tip-transducer telemetric ICP-sensor (Neurovent-P-tele). RESULTS: 30 min moderate exercise did not increase ICP (-6.1mmHg during seated rest vs -6.8mmHg during exercise). Invasive (N=1) and non-invasive (N=15) ICP recordings followed the same trend, demonstrating a 52.8±22.9% (P<0.005) decrease immediately postexercise and graduate returned to baseline (fig). ICP was correlated to MAP (r2=0.8, P<0.05) and TPR (r2=0.9, P<0.005) DISCUSSION: Postexercise decrease in ICP is a potential factor for maintaining cerebral perfusion pressure during arterial hypotension. Future analysis and ongoing trials are stratifying these responses according to responsiveness, gender and age. Supported by Novo Nordic Foundation (NNF150C0019196)

Acute and Recovery Effects of Aerobic Exercise on Serum Interleukin-6 in Adult Male Smokers

Background: Smoking is known to be the main risk factor in systemic inflammation and insulin resistance. Objectives: In the present study, the researchers aimed at comparing serum interleukin 6 as a pro-inflammatory cytokine between smokers and non-smokers and determining acute and recovery response of IL-6 to a single bout aerobic exercise in 2 groups. Methods: For this purpose, 15 adult male non-trained smokers (n = 15) and non-smokers (n = 15) matched for age (35.5 ± 5.8 years) and body mass index (BMI) (31.30 ± 4.5 kg/m2) were selected to participate in this study. Subjects of the 2 groups completed aerobic exercise consisting of 40 minutes of running on a flat surface with no slope at 70%maximal heart rate. Venous blood samples were collected before, immediately, 60 minutes and 24 hours after the exercise test of the 2 groups. Data were analyzed by one-way analysis of variance with repeated measures in each group. Results: Based on statistical data, serum Interleukin (IL)-6 level in smoker subjects was significantly higher than non-smokers at baseline. A significant increase was observed in serum IL-6, immediately after exercise test in smokers yet remained unchanged in nonsmokers. Interleukin-6 concentration decreased 1 and 24 hours after exercise compared with baseline in the 2 groups. Conclusions: Acute increase and recovery decrease in serum IL-6 response to exercise suggests an anti-inflammatory effect of moderate aerobic exercise on smokers.

Aerobic Exercise During Early Murine Doxorubicin Exposure Mitigates Cardiac Toxicity.

We report the cardioprotective effects of moderate aerobic exercise from parallel pediatric murine models of doxorubicin (Doxo) exposure in non-tumor-bearing immune competent (NTB-IC) mice and tumor-bearing nude mice (TB-NM). In both models, animals at 4 weeks of age underwent Doxo treatment with or without 2 weeks of simultaneous exercise. In sedentary NTB-IC or TB-NM mice, Doxo treatment resulted in a statistically significant decrease in ejection fraction and fractional shortening compared with control animals. Interestingly, moderate aerobic exercise during Doxo treatment significantly mitigated decreases in ejection fraction and fractional shortening. In contrast, these protective effects of exercise were not observed when exercise was started after completion of Doxo treatments. Moreover, in the TB-NM model, Doxo caused a decrease in heart mass: tibia length and in body weight that was prevented by exercise, whereas NTB-IC mice exhibited no change in these measurements. Doxo delivery to the hearts of TB-NM was decreased by consistent moderate aerobic exercise before Doxo injection. These findings demonstrate the important but subtle differences in cardiotoxicity observed in different mouse models. Collectively, these results also strongly suggest that aerobic exercise during early-life Doxo exposure mitigates cardiotoxicity, possibly through altered delivery of Doxo to myocardial tissue.