Effect Of Mesotherapy Research Articles

Effectiveness of Mesotherapy in Post-COVID Pain Syndrome: Retrospective Cohort Study of 96 Patients

PurposeMusculoskeletal pain may occur after becoming infected with SARS-Cov2. This study was designed to evaluate the efficacy of mesotherapy in treating chronic pain following COVID-19 infection. MethodsA retrospective review was conducted of the records of 96 patients with post-COVID pain syndrome. Those who were eligible for oral therapy or mesotherapy, included in the study. Patients receiving oral treatment with diclofenac potassium, thiocolchicoside and cyanocobalamin were included in one group (n = 46), and patients receiving intradermal mesotherapy with 2% lidocaine + cyanocobalamin were included in another group (n = 50). The results of the Visual Analogue Scale (VAS) and the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) were individually assessed before and one week after the treatment. FindingsThe participants were 40.2 ± 11.1 years old on average. Of the participants, 35.4% (n = 34) were male and 64.6% (n = 62) were female. Before treatment, there was no statistically significant difference between the patients in terms of VAS and LANSS scores. Following the treatment, a notable positive response was observed in both groups. Nevertheless, when compared to the oral treatment group, the mesotherapy group exhibited a more pronounced enhancement in VAS and LANSS scores (P < 0.001, P < 0.001, respectively). ImplicationsWhile both mesotherapy and oral therapy offer benefits in reducing pain and alleviating neuropathic symptoms in post-COVID pain syndrome, mesotherapy stands out as an especially effective and well-tolerated treatment method, surpassing the efficacy of the oral alternative.

Intradermal therapy (mesotherapy): the lower the better.

Intradermal therapy (mesotherapy) is a technique used to inject drugs into the surface layer of the skin. The intradermal micro deposit allows to modulate the kinetics of drugs, slowing down its absorption and prolonging the local mechanism of action. This technique is applied in the treatment of some forms of localized pain when a systemic drug-saving effect is useful, when it is necessary to synergize with other pharmacological or non-pharmacological thera-pies, when other therapies have failed or cannot be used. The purpose of our study was to evaluate the effect of a mixture with respect to its lower concentration. We also wanted to evaluate the number of sessions needed to reach the therapeutic goal (50% reduction in pain from baseline) in patients with acute or chronic neck pain. We analyzed retrospectively data from 62 patients with cervicobrachial pain treated with intradermal drugs. Group A received a mixture of drugs; group B received half the dose of drugs. Patients who received a lower concentration of drugs achieved similar results to those who received a higher dose. The therapeutic goal was achieved on average with 3.5 + 1.7 sessions on a weekly basis (min 1; max 9). Subjects in group A required 4+1.7 treatments (min 1; max 9), while subjects in group B required 3+1.5 treatments (min 1; max 7). Our study confirms that even a lower dose of drugs can induce a clinically useful result. This study confirms that the useful effect of mesotherapy is only partly due to the pharmacological action. Further randomized prospective studies are needed to standardize the technique in the various pain syndromes, but it is recommended to follow the guidelines of the Italian Society of Mesotherapy to ensure patients receive appropriate treatment.

Иммунологические аспекты эффектов мезотерапии гиалуроновой кислотой

Иммунологические аспекты эффектов мезотерапии гиалуроновой кислотой

Extracorporeal shockwave therapy versus musculoskeletal mesotherapy for Achilles tendinopathy in athlete

BackgroundAchilles tendinopathy (AT) is considered the commonest tendon pathology, occurring mainly in athletes. Different conservative treatment options have been introduced but with short-term effects; however, extracorporeal shockwave therapy (ESWT) and mesotherapy (MT) injections were claimed to provide longer effects and could be used in cases failure of response to conservative treatments.The objective of our prospective 12-week study was to compare the effect of ESWT and MT on chronic Achilles tendinopathy in athletes by both clinical and ultrasonographical assessment.ResultsForty patients with chronic AT diagnosed clinically and with high-resolution ultrasound (US) randomly allocated in two groups first received weekly ESWT session, and the other group underwent weekly MT sessions for 4 consecutive weeks. Both groups improved during the treatment and follow-up period. The mean visual analogue score (VAS) decreased in both the ESWT group and the MT group. Mean American Orthopedic Foot and Ankle Society (AOFAS) hindfoot score and VAS scores were not significantly different between ESWT and MT groups at the 4th and the 12th week of follow-up. However, US assessment significantly improved after 12 weeks in the ESWT group (as regards tendon thickness, calcifications, and Doppler signal), and for the mesotherapy group, there was the only improvement of tendon thickness.ConclusionESWT showed improvement of pain and inflammation and calcifications of AT than MT injections, which was documented by US improved findings at week 12 follow up.

Facial Rejuvenating Effects of Mesotherapy Using a New Polycomponent Formulation

Facial Rejuvenating Effects of Mesotherapy Using a New Polycomponent Formulation

Effectiveness of Mesotherapy on Temporomandibular Joint Disorders

Effectiveness of Mesotherapy on Temporomandibular Joint Disorders

Mesotherapy improves range of motion in patients with rotator cuff tendinitis

There is published evidence on the effect of mesotherapy for inflammatory shoulder diseases. Objective: Evaluate the gain in range of motion (ROM) in patients with rotator cuff tendinopathy treated with mesotherapy. A retrospective series of cases conducted from medical records. Location: an outpatient rehabilitation and orthopedic service. 145 patients with clinical diagnosis of rotator cuff tendinopathy, with limited active range of motion. Method: The study subjects were treated with mesotherapy between 1995 and 2008, the blends were selected according to the patient’s profile and tolerance. The effect on the ROM was qualified as “not improved” or “improved”. The improvement in symptomatology was correlated to age, duration of symptoms, and drugs used in the mesotherapy. The concomitant application of physical therapy was also correlated with the result. The adverse effects were evaluated systematically. Results: 117 patients (80.7%) presented objective improvement of ROM or of pain. The result was not influenced by age, duration of symptoms, or by the concomitant application of physical therapy. Only smaller adverse effects were observed. Conclusion: This study suggests that mesotherapy can be efficient in the treatment of rotator cuff tendinopathy, for the improvement of pain, ROM, or global functioning of the upper limb. The clinical impact of this study is that mesotherapy can be associated with the standard physical therapy treatment to improve ROM and pain in rotator cuff tendinopathy.

Effect of the mesotherapy with the use of Ekyced P.I. cream on age-related changes in skin

Sixty women (average age: 44.8+1,1) underwent examination with the use of Skin XP Pro software, laser Doppler flowmetry and CAH psychological test for assessment of the effect of mesotherapy (MT) with the use of Ekyced P.I. cream on age-related changes in facial skin. A course of MT with the use of Ekyced P.I. cream, which was applied prior to and after mesotherapy, as well as Ubichinon Compositum and Placenta Compositum resulted in an evident reduction in the intensity of wrinkles, increase in the level of elasticity and hydration as well as normalization of the level of skin oiliness. The use of Ekyced P.I. regenerating cream resulted in a considerable reduction in the frequency of development of MT side effects such as edemas, erythema, purpura. Mesotherapy with the use of Ekyced P.I. in women older than 45 was accompanied by a more evident increase in the level of skin hydration and elasticity than in women younger than 45.

Effectiveness of Mesotherapy on Body Contouring

Effectiveness of Mesotherapy on Body Contouring

Effectiveness of Mesotherapy on Body Contouring

Despite the increasing interest in mesotherapy as an alternative method for body contouring, there are few reports of its safety, efficacy, and mechanism of action. A clinical examination was performed to evaluate the efficacy of mesotherapy for body contouring. Twenty women were enrolled in this prospective, case-controlled study over a 12-week period. The authors injected a mixed solution (i.e., aminophylline, buflomedil, and lidocaine) into the superficial dermis of the medial aspect of one thigh weekly using a mechanical delivery gun. There was no treatment to the other thigh. The change in the fat level was evaluated by measuring the girth of the thighs and by computed tomographic scanning. The lipid profiles were checked to determine the effect of mesotherapy on lipid metabolism, and questionnaires were used to determine the satisfaction rate of the patients. The loss of thigh girth on the treated side was not significantly different from that of the untreated side. The computed tomographic scans showed no statistically significant difference in the cross-sectional area or thickness of the fat layer between each group. There were no statistically significant changes in the lipid profiles except for the triglyceride level. A questionnaire asking about the effect of mesotherapy indicated poor patient satisfaction. Mesotherapy is not an effective alternative treatment modality for body contouring.

Morris Animal Foundation equine study accomplishments – May 1, 2005 to September 30, 2005

To evaluate the feasibility and effectiveness of mesotherapy in dogs compared with a positive control group.Experimental, randomized, blinded study.Fifteen working police dogs with chronic back pain.Animals were divided randomly into control (CG; n = 5) and treatment groups (TG; n = 10). A combination of 140 mg lidocaine, 15 mg dexamethasone and 20 mg thiocolchicoside was administered to group TG along with a 70-day course of a placebo, administered as if it was carprofen. Carprofen was administered to Group CG for 70 days, at a dose adjusted to their weight. On day 0, an intradermal injection of Ringer’s lactate was also administered. Both groups were rested for 3 days and resumed normal activity over a 5-day period. Response to treatment, measured by the Canine Brief Pain Inventory (CBPI) and the Hudson Visual Analogue Scale (HVAS), was evaluated before treatment (T0), after 15 days (T1) and 1 (T2), 2 (T3), 3 (T4), 4 (T5) and 5 (T6) months. Results were compared using a Mann–Whitney test or a paired samples t test.When comparing CBPI results, no differences were found between groups TG and CG at T0 through T3 and in T6 and T7. Differences were observed in CBPI sections after the discontinuation of carprofen: at T4 [p = 0.02 for Pain Interference Score (PIS) and p = 0.03 for Pain Severity Score (PSS)] and T5 (p = 0.16 for PIS and p = 0.03 for PSS), with group TG having overall better results. Individual treatment results were considered successful in one dog of group CG (20%), whereas in group TG, success was higher (ranging from 78% at T1 to 22% at T7). No significant differences were registered with the HVAS.Mesotherapy may be a promising treatment option for canine musculoskeletal-related pain. Further studies are required.

The science of mesotherapy: Chemical anarchy

The author stresses that to date, the effects of mesotherapy have not been scientifically evaluated. Currently, there is no standardization of dosage and no protocol or treatment algorithm to enable prediction of how much tissue or fat will be "dissolved" with a specific solution in a defined quantity, and injected at a specified subcutaneous tissue depth.