Effect Of Griseofulvin Research Articles

Effect of griseofulvin on tinea capitis caused by Microsporum audouini.

Introduction The curative effect of griseofulvin in tinea capitis caused by Microsporum audouini has been established by the few reports which have been published. Williams, Marten, and Sarkany1were the first to report such a cure; Blank and Roth2also included one patient with scalp infection caused by Microsporum audouini who was successfully treated with griseofulvin. Recently, a series of children with M. audouini infection of the scalp treated with griseofulvin has been reported from Washington, D.C.3Tinea capitis caused by dermatophytes other than M. audouini has also been treated successfully by griseofulvin.2-6The frequency, the anthropophilic aspect, and the resistance to all forms of therapy other than x-ray epilation make tinea capitis caused by M. audouini one of the most important of the dermatophyte infections. The present study was initiated to determine the optimum dosage and treatment schedule necessary to best manage tinea capitis produced

Experiences in one hundred thirty-seven patients treated with oral griseofulvin. Special reference to clinical recurrences. the healthy carrier state, and their management.

Shortly after the original publication of Gentles 1 on the effectiveness of griseofulvin in Trichophyton infections of laboratory animals, numerous investigators have reported on striking clinical results obtained with the oral administration of griseofulvin in treatment of superficial dermatomycoses in man. Williams et al., 2 Riehl, 3 Blank and Roth, 4 and Pardo-Castello 5 were among the first attempting such clinical studies. A main purpose of this paper is to evalu ate the recurrences noted in patients either after completion of a course of oral therapy with griseofulvin or in evidence during the course of treatment . The management of these cases will be discussed. Several patients, moreover, were found to have persistently positive mycological laboratory findings despite apparent clinical cure. This situation we have designated as the healthy carrier state. Method We wish to call attention to the fact that our studies commenced in the winter months and extended into

Griseofulvin and Human Spermatogenesis

The effect of griseofulvin on human spermatogenesis has been investigated in two groups of persons for periods ranging from three to six months at a daily intake level of 2 gm. These men, in normal health, were confined in two separate institutions, and each group was living under the same conditions of diet and exercise. The first group of 14 men (Table 1) was in the age group of 23-47 years (mean age 33), the second, of 12 persons, ranged in age from 20 to 45 years with a mean age of 31. The same investigative protocol was followed in both groups. Testicular biopsies were obtained during a short control period in which two semen specimens were examined to establish the level of semen quality prior to therapy. Thereafter, in the first group, the griseofulvin was taken orally (2 gm. daily) for three months, and in the second group, the

Laboratory experiences with griseofulvin.

Sensitivity tests with griseofulvin were generally speaking in agreement with published data, 1 but a variation was introduced in this laboratory by testing the drug simultaneously with penicillinase in order to establish whether it would be inactivated by this enzyme. No influence was found on incorporation of penicillinase into griseofulvin-containing media. 2 In order to study the mechanism of the curling factor, colonies of dermatophytes were permitted to develop on solid media (Sabouraud's dextrose agar). Small amount of griseofulvin powder were then deposited on the surface of the agar, a few millimeters distant from one side of the colony. Within a few hours, depending on the distance between the griseofulvin powder and the colony, formerly straight hyphae first became wavy, then curled, clumped together, and looked as degenerated and dejected as can be. However, after a few days the colony revived and the fungistatic effect of griseofulvin obviously was overcome, since growth occurred not only locally, but also on top of the griseofulvin powder. We have not investigated how this inactivation of the griseofulvin occurs. This method lends itself

The treatment of endothrix Trichophyton infections with griseofulvin.

Clinical experiences cited in twelve articles 1-12 published during the past year established the therapeutic effectiveness of griseofulvin in tinea capitis. The early reports revealed a paucity of patients with Trichophyton endothrix infections so treated. This prompted us to enlarge on our preliminary studies 5 in which we obtained apparent cures in 14 T. tonsurans and 4 T. violaceum infections of the scalp. In our locale, where endothrix Trichophyton infections have been endemic for many years, a large reservoir of catalogued material has been accumulated. Since spontaneous recovery is rare in these infections and earlier known treatment has been largely ineffective, there was adequate material at hand for such a study. Clinical Material During the past 10 months 64 patients with endothrix Trichophyton infections of the scalp, skin, and/or nails have been treated with griseofulvin. Remarks will pertain to only 54 of these patients because of inadequate follow-up on 10.

Presence of griseofulvin in hair of guinea pigs after oral administration.

GENTLES1 has found that oral administration of griseofulvin to guinea pigs previously infected with either Microsporum canis or Trichophyton mentagrophytes arrests the progress of the fungal disease and prevents the highly inflammatory reaction normally encountered in untreated animals. Histological examination showed that most of the hair follicles and most of the lower portions of hair-shafts were free from dermatophytes after a few oral doses of the antibiotic. The hyphal tips of the fungi were sometimes malformed and in that way reminiscent of the effect of griseofulvin on other susceptible fungi.