Background: The objective is to assess the association of body fluid load in the pathogenesis of sinonasal polyposis. Subjects and Methods: The targeted cases with chronic rhinosinusitis (CRS) with nasal polyposis and control of CRS without polyposis were randomly taken from the admitted patients. Two groups of 30 people each were taken. Demographic details such as name, age, and gender were noted. Excess body water was then calculated by subtracting the perfect body water from the total body water (TBW). Results: Of 30 cases and 30 controls aged 18–60, the median was 30.5, and the mean was 34 ± 12.8 years. The gender of the case was 18 males and 12 females, while in control, the males and females were of equal number. The mean TBW was 34.4 ± 5.27 L in cases and 32.4 ± 5.87 L in controls. Total body weight was found to be higher in cases than in controls but not found to be statistically significant (P = 0.160). Excess body water was found in 60% of nasal polyps cases and 46.7% of controls, which was statistically insignificant (P = 0.301). Conclusion: There is a complex interplay between our body fluid dynamics and nasal polyp pathogenesis in CRS with polyposis. While our findings suggest potential trends with small sample sizes, further research with more extensive and diverse populations is needed to authenticate and expand on these observations.
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