Work-related injuries in healthcare facilities are highly prevalent. This study examines the effectiveness of ergonomic interventions in 111 healthcare facilities on reducing musculoskeletal disorders (MSDs). Data from OSHA logs were collected prior to (baseline) and after implementing (follow-up) engineering controls. The average length of the baseline period was 445 days, and the average length of follow-up was 629 days. Overall, 83 work units (64%) experienced a decrease in the MSD rates during the follow-up period (z = −5.193, p< .001). The median rate ratio for all interventions was .63; that is, the intervention is associated with overall 37% decrease in MSD rates. The decrease in back injury rates observed in the study (44%) was much higher than the decline in the national data (17%). This study demonstrates that ergonomic interventions in healthcare facilities can result in decreased MSD rates.