Effect Of Enteral Nutrition Support Research Articles

Effect of Enteral Nutrition Support in Conjunction with Rapid Rehabilitation Surgery on Postoperative Recovery of Elderly Patients with Colorectal Cancer

This study aimed to explore the effect of enteral nutrition support, based on the rapid rehabilitation surgery concept, on the postoperative recovery and nutritional status of elderly patients with colorectal cancer. One hundred patients who underwent radical laparoscopic surgery for colorectal cancer in our department from January 2021 to December 2022 were included. Traditional nursing measures were adopted for patients in the control group, while early enteral nutrition support based on accelerated rehabilitation surgery was provided to patients in the observation group. Our findings revealed that the time to get out of bed, exhaust, defecate, have the first feeding, and hospital stay was shorter in the observation group than in the control group (P < 0.05). Following nursing, the occurrence of complications, serum C-reactive protein levels, and lymphocyte count decreased (P < 0.05), while the nutritional and immune indexes, as well as SF-36 scores increased (P < 0.05) in the observation group compared to the control group. Our results suggested that early enteral nutrition support based on rapid rehabilitation surgery can significantly improve the nutritional and immune indexes of patients undergoing colorectal cancer surgery and has good clinical efficacy.

Effect of enteral nutritional support on clinical outcomes of patients with sepsis

To research whether clinical outcomes of patients with sepsis can be improved by higher enteral nutritional support. A retrospective cohort method was applied. 145 patients with sepsis who were hospitalized in intensive care unit (ICU) of Peking University Third Hospital from September, 2015 to August, 2021 and met inclusion criteria as well as exclusion criteria were selected, including 79 males and 66 females, the median age was 68 (61, 73). Researchers evaluated whether there was correlation between improved modified nutrition risk in critically ill score (mNUTRIC), daily energy intake and protein supplement of patients and their clinical outcomes through Poisson log-linear regression analysis and Cox regression analysis. The median of mNUTRIC score of 145 hospitalized patients was 6 (3, 10), wherein 70.3% of patients (102 cases) were in high-score group (≥ 5 scores) and 29.7% of patients (43 cases) were in low-score group (< 5 scores); the average of daily protein intake in ICU was about 0.62 (0.43, 0.79) g×kg-1×d-1, and the average of daily energy intake was about 64.4 (48.1, 86.2) kJ×kg-1×d-1. As shown by Cox regression analysis, increase of mNUTRIC score, sequential organ failure assessment (SOFA), and acute physiology and chronic health evaluation II (APACHE II) were correlated to growth of in-hospital mortality [hazard ratio (HR) = 1.12, 95% confidence interval (95%CI) was 1.08-1.16, P = 0.006; HR = 1.04, 95%CI was 1.01-1.08, P = 0.030; HR = 1.08, 95%CI was 1.03-1.13, P = 0.023]. Higher average daily intake of protein and energy as well as lower mNUTRIC, SOFA, and APACHE II scores were also significantly correlated to lower 30-day mortality (HR = 0.45, 95%CI was 0.25-0.65, P < 0.001; HR = 0.77, 95%CI was 0.61-0.93, P < 0.001; HR = 1.10, 95%CI was 1.07-1.13, P < 0.001; HR = 1.07, 95%CI was 1.02-1.13, P = 0.041; HR = 1.15, 95%CI was 1.05-1.23, P = 0.014); however, there was no significant correlation between gender as well as number of complications and in-hospital mortality. Within 30 days of attack of sepsis, the average daily intake of protein and energy were not correlated to days of non-ventilator (HR = 0.66, 95%CI was 0.59-0.74, P = 0.066; HR = 0.78, 95%CI was 0.63-0.93, P = 0.073). Increase of patients' average daily intake of protein and energy were significantly correlated to a lower in-hospital mortality (HR = 0.41, 95%CI was 0.32-0.50, P < 0.001; HR = 0.87, 95%CI was 0.84-0.92, P < 0.001), shorter ICU stay (HR = 0.46, 95%CI was 0.39-0.53, P < 0.001; HR = 0.82, 95%CI was 0.78-0.86, P < 0.001), and hospital stay (HR = 0.51, 95%CI was 0.44-0.58, P < 0.001; HR = 0.77, 95%CI was 0.68-0.88, P < 0.001). According to correlation analysis, among patients with mNUTRIC score ≥ 5, increasing daily intake of protein and energy can reduce in-hospital mortality (HR = 0.44, 95%CI was 0.32-0.58, P < 0.001; HR = 0.73, 95%CI was 0.69-0.77, P < 0.001), and 30-day mortality (HR = 0.51, 95%CI was 0.37-0.65, P < 0.001; HR = 0.90, 95%CI was 0.85-0.96, P < 0.001); the receiver operator characteristic curve (ROC curve) further confirmed that higher protein intake had good predictive value for inpatient mortality area under the curve (AUC) = 0.96 and 30-day mortality (AUC = 0.94); higher emergy intake had good predictive value for inpatient mortality (AUC = 0.87) and 30-day mortality (AUC = 0.83). By contrast, among patients with mNUTRIC score < 5, it is only discovered that increasing daily intake of protein and energy can reduce 30-day mortality of patients (HR = 0.76, 95%CI was 0.69-0.83, P < 0.001). The increase of average daily intake of protein and energy for patients with sepsis is significantly correlated to reduction of in-hospital mortality and 30-day mortality, shorter ICU stay, and hospital stay. The correlation is more significant in patients with high mNUTRIC score, and higher intake of protein and energy can bring down in-hospital mortality and 30-day mortality. As for patients with low mNUTRIC score, nutritional support cannot improve prognosis of the patients significantly.

Enteral Nutrition: Based on the Combination of Nutrison Fibre and TPF-DM with A Marine Biological-Based Active Polysaccharide Preparation.

Good nutrition is essential for human growth, wound healing, and spiritual vitality. However, some individuals are unable to eat or experience gastrointestinal problems such as severe diarrhea, vomiting, gastric retention, and even gastrointestinal bleeding for a variety of causes. Therefore, it has important clinical significance to provide patients with required nutrients and maintain the integrity of the body's tissues and organs through enteral nutrition. Based on this, this work uses a dual carrier of polylactic acid (PLA) and polyvinyl alcohol (PVA) to carry marine biopolysaccharides combined with sodium alginate (PSS) and successfully obtains the intestinal tract based on marine bioactive polysaccharides. Nutritional oral biological preparations (PSS-PLA/PVA) also cooperate with enteral nutritional suspension (diabetes) (TPF-DM) and Nutrison fibre to provide enteral nutritional support for critically ill patients. PSS-PLA/PVA has been shown in clinical studies to increase the effect of enteral nutrition support, the function of intestinal T lymphatic tissue, and the ability to control immunological function, indicating that it is worthy of further clinical development.

Discussion on Nursing Intervention Method and Implementation Effect of Enteral Nutrition Support after Total Gastrectomy for Gastric Cancer

Discussion on Nursing Intervention Method and Implementation Effect of Enteral Nutrition Support after Total Gastrectomy for Gastric Cancer

Analysis of Effect of Enteral Nutritional Support in Patients with Femoral Neck Fractures

Analysis of Effect of Enteral Nutritional Support in Patients with Femoral Neck Fractures

Evaluation of Nursing Effect of Enteral Nutrition Support after Total Gastrectomy for Gastric Cancer

Evaluation of Nursing Effect of Enteral Nutrition Support after Total Gastrectomy for Gastric Cancer

Clinical effect of enteral nutrition support during neoadjuvant chemotherapy on the preservation of skeletal muscle mass in patients with esophageal cancer

Reductions in skeletal muscle mass during neoadjuvant therapy can have a negative effect on short- and long-term outcomes in patients with esophageal cancer. However, effective treatment for suppressing reductions in skeletal muscle mass during neoadjuvant therapy has not been established. Eighty-seven patients were included in this study who were enrolled in a previous randomized study comparing the effects of enteral nutrition (EN) and parenteral nutrition (PN) on chemotherapy-related toxicities during neoadjuvant chemotherapy in esophageal cancer patients. Changes in skeletal muscle mass during neoadjuvant therapy were compared between the two groups. Skeletal muscle mass index (SMI) decreased from 45.8cm2/m2 before treatment to 43.7cm2/m2 after neoadjuvant chemotherapy in 87 patients (p=0.092). The total calorie intake during neoadjuvant therapy was equal between the two groups. SMI reduction was significantly smaller in the EN group than in the PN group (-1.4cm2/m2 vs-3.0cm2/m (Gebski etal., 2007) [2], p<0.001). EN support was identified as the only independent factor adversely associated with severe SMI reduction (p<0.001). Patients with low SMI after neoadjuvant chemotherapy were more susceptible to postoperative complications than patients with moderate SMI (47.6% vs 16.7%, p=0.007), especially pulmonary complications (31.8% vs 10.8%, p=0.003). Patients with low SMI after neoadjuvant chemotherapy tended to show worse prognosis than patients with moderate SMI (5-year overall survival rate: 43.8% vs 62.1%, p=0.194). Compared with PN support, EN support during neoadjuvant chemotherapy suppressed reductions in skeletal muscle mass in patients with esophageal cancer.

Effect of enteral nutritional support on nutritional status of patients with gastric cancer receiving chemoradiotherapy after gastrectomy

Aim: To evaluate the effects of enteral nutritional support in gastric cancer patients who received chemoradiotherapy (CRT) after gastrectomy. Materials and Methods: Patients who underwent total/subtotal gastrectomy due to gastric cancer and received postoperative CRT between January 1, 2010 and December 31, 2015 at Zonguldak Bulent Ecevit University Faculty of Medicine General Surgery Clinic were included in the study. The nutritional risk of patients was recorded using NRS-2002. The values of patients at the scheduled routine clinical follow-up at the end of the first year were compared with baseline values. Results: While 64.7% (n=22) of the patients continued to receive enteral nutritional support regularly (CNS group), 35.3% of the patients (n=12) discontinued nutritional support (DNS group). Patients in the DNS group had significantly lower baseline NRS-2002 scores (p=0.049). The NRS-2002 score of the CNS group decreased significantly at follow-up compared to the pre-CRT values. At the end of the first year, statistically significant increases were found in body weight, body mass index, transferrin level and vitamin D level of both patient groups. While the mean RBC count decreased significantly in the CNS group (p=0.002), there was no significant difference in the DNS group (p=0.382). When the amount of temporal change in RBC was evaluated, there was a significant difference between the DNS and CNS groups. Although vitamin B12 level and urea level increased in both groups, this increase was significant only in the DNS group (p = 0.049). Conclusions: In this study, it was determined that gastric cancer patients who continued enteral nutrition in the first year after CRT had significantly higher nutritional risk before CRT. Enteral nutrition reduces nutritional risk and shows positive results on nutritional parameters such as body weight, ferritin, transferrin, vitamin D, vitamin B12.

Effects of enteral nutrition support combined with enhanced recovery after surgery on the nutritional status, immune function, and prognosis of patients with esophageal cancer after Ivor-Lewis operation.

BackgroundEsophageal cancer (EC) with a high incidence of malnutrition is a highly malignant digestive tract tumor. We investigated the effect of enteral nutrition (EN) support combined with enhanced recovery after surgery (ERAS) on the nutritional status, immune function, and prognosis of patients with EC after Ivor-Lewis operation.MethodsOne hundred patients were randomly divided into the observation group (n=42) and the control group (n=58). The patients in observation group were treated with EN combined with ERAS intervention after Ivor-Lewis operation, and the patients in control group were treated with conventional postoperative EN intervention. The situation of operation, nutritional status, immune function recovery and prognosis between the two groups were compared.ResultsThere was no statistically significant difference in operation time or intraoperative blood loss between the two groups (P>0.05). The chest tube removal time and oral feeding time of the observation group after operation were shorter than those of the control group (P<0.05). After intervention, serum albumin (ALB), transferrin (TF), pre-albumin (PA) and hemoglobin (Hb) levels in both groups were significantly decreased. These indexes were significantly higher in the observation group than in the control group (P<0.05). There were no significant changes in the levels of immunoglobulin (Ig) A, IgG, and IgM, or the numbers of CD3+, CD4+ and CD4+/CD8+ T cells in the observation group before and after intervention (P>0.05); however those indexes were significantly decreased in the control group after the intervention (P<0.05). Interestingly, the levels of IgA, IgM, IgG, CD3+ T cells, CD4+ T cells and CD4+/CD8+ T cells in the observation group were significantly higher than those in the control group after intervention (P<0.05). The incidence of pulmonary infection in the observation group was significantly lower than that in the control group. The postoperative exhaust time, postoperative defecation time and postoperative hospital stay were shorter in the observation group than in the control group (P<0.05). There was no significant difference in hospitalization cost between the two groups (P>0.05).ConclusionsEN combined with ERAS was more beneficial to the improvement of nutritional status and immune function recovery of patients with EC after Ivor-Lewis operation. It also shortened the length of hospital stay.

Observation on the Effect of Enteral Nutrition Support on Senile Femoral Neck Fracture

Observation on the Effect of Enteral Nutrition Support on Senile Femoral Neck Fracture

Therapeutic effects of enteral nutrition support combined with rehabilitation therapy in senile dementia patients with malnutrition

Objective To investigate changes in nutritional status in senile dementia patients with malnutrition treated with enteral nutrition combined with rehabilitation therapy evaluated by using the Mini Nutritional Assessment-Short Form(MNA-SF). Methods Fifty hospitalized patients with senile dementia and malnutrition at the internal medicine department of our hospital from July 2014 to July 2017 were enrolled and further divided into an enteral nutrition group(a control group, n=25)and an enteral nutrition combined with rehabilitation therapy group(an observation group, n=25). Anthropometric parameters including body mass index, biceps circumference, calf circumference, triceps skin-fold thickness, and blood biochemical parameters including hemoglobin, total cholesterol, triacylglycerol, albumin, lymphocyte count before and after treatment were compared between the groups. Results Anthropometric parameters such as body mass index, biceps circumference, calf circumference and triceps skin-fold thickness had no significant difference between the two groups before treatment(P>0.05), while after 30 days of treatment, anthropometric parameters saw improvement in both groups compared with those before treatment, and the improvement was greater in the observation group than in the control group(P 0.05). After 30 days of treatment, levels of total cholesterol and triacylglycerol had no significant difference compared with those before treatment or between the two groups(P>0.05), while levels of hemoglobin, albumin and lymphocyte count improved compared with those before treatment(t=2.645, 2.843, 2.967, respectively, P<0.01), and had significant differences between the groups(t=2.548, 2.864, 2.976, respectively, P<0.01). Conclusions Enteral nutrition combined with rehabilitation therapy has a measurable, positive influence on nutritional status in senile dementia patients with malnutrition. Key words: Enteral nutrition; Rehabilitation; Dementia; Malnutrition

Enteral nutrition supports early blood glucose control and nursing of patients after pancreaticoduodenectomy

Objective To investigate the effect of enteral nutrition support on early blood glucose control and nursing of patients after pancreaticoduodenectomy. Methods A total of 60 patients who underwent pancreaticoduodenectomy in hepatobiliary and pancreatic surgery department of the hospital from July 2014 to July 2017 were selected as the study objects and were randomly divided into control group and observation group, 30 cases of each group. The control group received parenteral nutrition support, and the observation group received parenteral nutrition support. Postoperative blood glucose value, length of hospitalization, time of anal exhaust and time of recovery and defecation were taken as evaluation indexes. Results There was no significant difference in blood glucose between the two groups before operation(P>0.05). Postoperative blood glucose of the two groups showed a trend of increasing first and then decreasing, and the difference was statistically significant(P<0.05). However, 1 day, 3 days and 7 days after surgery, the blood glucose values of the observation group were significantly lower than those of the control group, with statistically significant differences(P<0.05). The hospitalization time, anus exhaust time, recovery defecation time, nutritional status and other surgical indicators in the observation group were significantly lower than those in the control group, with statistically significant differences(P<0.05). Nursing satisfaction in the observation group was significantly higher than that in the control group, and the difference was statistically significant(P<0.05). The incidence of complications in the observation group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05). In the observation group, there was 1 case of delayed gastric emptying, 4 cases of postoperative bleeding, 1 case of pancreatic fistula and 1 case of biliary fistula in the control group. Conclusions The effect of enteral nutrition support on early blood glucose control in patients with pancreaticoduodenectomy is significant, which can significantly shorten the hospitalization time, promote the recovery of gastrointestinal function, improve the nutritional status of patients, reduce the incidence of complications, and improve nursing satisfaction, which is worthy of clinical promotion and application. Key words: Enteral nutrition support; Pancreaticoduodenectomy; Blood glucose control; Nursing

Application of enteral nutrition support via naso-jejunal tube in esophageal carcinoma patients treated with radiotheraphy

Objective To investigate the effect of enteral nutrition support via naso-jejunal tube in esophageal carcinoma patients treated with radiotheraphy. Methods 36 esophageal carcinoma patients were randomly assigned into enteral nutrition(EN) group, while 38 patients assigned to control group.All patients underwent definition IMRT combined with weekly concurrent chemotherapy of paclitaxel-nedaplatin.The naso-jejunal tubes were bedside inserted by hand in EN group.Enteral nutrition support began the day after the tube insertion.The control group took food orally.Nutrition was assessed through body weight, BMI, lymphocyte, albumin, pre-albumin and hemoglobin.Treatment induced complications were recorded. Results The degree of nutritional reduction was lower in EN group and significantly different with the control group.The EN group underwent (4.5±1.1)cycles concurrent chemotherapy, the control group underwent (3.1±2.3)cycles concurrent chemotherapy(t=6.21, P=0.027). The hematotoxicity induced by chemoradiotherapy(CRT) was statistically severe in the control group(χ2=24.64, P<0.01), while radiation esophagitis was similar between the two groups. Conclusion EN support via naso-jejunal tube in esophageal carcinoma patients treated with radiotheraphy may improve the nutritional status, alleviate CRT induced hematotoxicity, increase tolerance of CRT. Key words: Esophageal neoplasms; Enteral nutrition

Application of glutamine combined with dietary fibre and fructo-oligosaccharide in enteral nutrition support of elderly patients with mechanical ventilation

Objective To investigate the effects of enteral nutrition support with glutamine combined with dietary fibre and fructo-oligosaccharide (GFO) on nutritional status, gastrointestinal function and outcome in elderly patients with mechanical ventilation. Methods Totally 90 patients were randomly divided into three group: the control group without additives (group A), enteral nutrition group with glutamine (group B) or with GFO (group C). Fasting blood samples were collected on day 1, 7 and 14 after the initiation of study, and then the indicators including hemoglobin, albumin, transferrin and prealbumin were determined.In addition, the gastrointestinal complications including bloating, diarrhea, and gastric retention were observed, and the mechanical ventilation time, length of intensive care unit (ICU) stay and extubation time were recorded. Results The serum transferrin and prealbumin levels were significantly improved on the 7th day (P=0.023 and 0.047), and the hemoglobin was significantly improved on the 14th day (P=0.003). 4 cases in group B and 3 cases in group C underwent successful implementation of enteral nutrition, and 25 cases in group B and 27 cases in group C achieved the target volume of enteral nutrition, which were more than those in group A (P=0. 008 and 0.000 respectively). The incidence of gastrointestinal complication was less in groups B and C than in group A. The mechanical ventilation time, length of ICU stay and extubation time were shorter in groups B and C than in group A. Conclusions Enteral nutrition with glutamine and GFO can improve nutritional status and reduce gastrointestinal complications in elderly patients with mechanical ventilation. Enteral nutrition with GFO has an advantage to the enteral nutrition and the outcome. Key words: Glutamine; Dietary fiber; Oligosaccharides; Enteral nutrition; Continuous positive airway pressure

Unintended Adverse Effects of Enteral Nutrition Support: Parental Perspective.

The present study highlights the occurrence of unintended adverse effects of enteral nutrition in infancy and childhood, as viewed and reported from a parental perspective. Quantitative analysis of a standardized questionnaire, filled out online by parents of enterally fed children. The questions focused on the nutritive and nonnutritive adverse effects, and other medical and biometric data. Data were collected from January 1, 2009 to December 31, 2013. The study cohort consisted of 425 infants and children with different underlying medical conditions and an average age of 2.17 (median = 1.63) years. Nasogastric tubes were used in 44.2% of all the patients, and 55.8% of the children were fed by percutaneous endoscopic gastrostomy tube. Nearly all of the children have been tube-fed since birth. A total of 56.0% of all tube-fed children showed regular gagging and retching episodes, 50.0% vomited frequently, 14.8% experienced nausea, 7.5% experienced extreme nervous perspiration during the feeding, 45.2% showed loss of appetite, 5.2% experienced local granulation tissue, and 1.9% had other skin irritations. No significant correlations could be found between age, sex, medical diagnoses, type of feeding tube, feeding schedules (bolus or continuous), and parental and child's behavior regarding the feeding situation and duration of tube feeding. Enteral nutrition affects the child and the whole family system on more than just nutritional level. It is suggested that children and their families should be followed-up by health professionals periodically for nutritional optimization, growth documentation, and other aspects of tube management.

The effect of enteral nutritional support on nutritional status of nasopharyngeal carcinoma patients with concurrent chemoradiation

Objective To discuss the effect of enteral nutritional support on nutritional status of nasopharyngeal carcinoma patients with concurrent chemoradiation. Methods A total of 50 volunteer patients were treated by percutaneous endoscopic gastrostomy(PEG) before concurrent chemoradiation, completely by enteral nutrition support from the first day concurrent chemoradiation to one month after the end. The nutritional risks and nutritional status were evaluated before and after treatment. Results There were not statistical differences on the patients received enteral nutritional support via PEGPH values for PEGthe nutritional risks (NRS-2002), malnutrition incidence rates(SGA)and nutrition index between before and after the fourteen day, at end of chemoradiation and one month after the end of chemoradiation. Conclusions Nasopharyngeal carcinoma patients treated by PEGbefore concurrent chemoradiation, would be given enteral nutrition support timely and efficiently, which could reduce the nutritional risk, improve patient's nutrition condition and immunologic function, enhance the quality of life. Key words: Nasopharyngeal carcinoma; Enteral nutrition support; Nutrition condition

Effect of nutritional support on therapy-related side effects in acute lymphoblastic leukemia children undergoing chemotherapy

Objective To analyze the changes in nutritional status changes of pediatric acute lymphoblastic leukemia (ALL) patients before and after chemotherapy and to evaluate the effects of enteral nutritional support on the states of nutrition and complication of chemotherapy. Methods Sixty-two newly diagnosed ALL patients from November 2012 to December 2013 in Center of Hematology, Beijing Children's Hospital Affiliated to Capital Medical University were enrolled in this study.Patients were randomly assigned into an intervention group and a control group.During the induction and the early consolidation chemotherapy, the control group was given routine low fat diet routinely, and the intervention group was given Nestle peptamen[20 mL/(kg·d)]as the enteral nutritional support, meanwhile the routine low fat diet was also given.Changes in the nutritional status before and after chemotherapy and effectiveness of nutritional complementary therapy for preventing the chemotherapy complications were analyzed. Results (1)Basic information: there was no significant difference in age, gender, risk group, anthropometry, albumin and pre-albumin level between 2 groups before chemotherapy.(2)Nutritional status: the rate of malnutrition was 11.3%, and skinniness cases under 5 years of age occupied 10.0%.In the control group, the Z scores of W/H (weight-for-length/height, t=3.160, P=0.040), the Z scores of BMI (body mass index, t=3.490, P=0.010) and the albumin level(t=-1.805, P<0.001) decreased after chemotherapy, and the difference was statistically significant.On the other hand, the Z scores of W/H and BMI kept stable after chemotherapy in the intervention group, the albumin level raised from (40.53±3.96)g/L to (44.36±3.31)g/L(t=-4.500, P<0.001)and the pre-albumin level raised from(126.55±39.28)g/L to (189.55±51.81)g/L(t=2.710, P=0.010), which was of statistical difference.The albumin level(t=5.020, P<0.001), pre-albumin level(t=3.036, P=0.040)and the Z scores of W/H(t=2.790, P=0.010), BMI(t=3.370, P<0.001), weight for age(W/A, t=2.830, P=0.010)were all higher in the intervention group, and the differences in statistical significance were found.(3)Side effects of chemotherapy: patients in the intervention group had higher hemoglobin (t=2.070, P=0.043)and platelet (Z=-2.19, P=0.033)level during the chemotherapy which induce less platelet[(0.50±1.00)U vs (2.00±2.00)U; Z=-3.53, P=0.003] and red blood cells[(3.87±2.01)U vs (5.25±1.87)U; t=-2.810, P=0.007] transfusion.Period of neutrophil deficiency[(15.67±8.85)d vs (25.94±8.72) d; t=-4.601, P<0.001]was also shorter than that in the control group.Other complications had no difference between two groups exclude mild liver function abnormality was found more in the controls(χ2=6.680, P=0.010). (4)Safety: the complete remission rate 15 days after chemotherapy was 83.3% in the intervention group and 81.2% in the control group (χ2=0.046, P=0.830). All patients got complete remission on day 33.There was no significant difference.No pancreatitis happened in both groups during the chemotherapy. Conclusions Malnutrition rate is high among newly diagnosed ALL pediatric patients, and the nutritional status will deteriorate during the chemotherapy.Enteral nutritional support contributes to maintaining the stability of nutritional status.Enteral nutritional support improves the tolerance of hematopoietic system to chemotherapy.The effect for other complications remains to be confirmed by more extensive study in future.Nestle peptamenas enteral nutritional support productions are safe for ALL patients undergoing chemotherapy. Key words: Child; Acute lymphoblastic leukemia; Chemotherapy; Enteral nutritional support

Effects of enteral nutritional support on malnourished patients with inflammatory bowel disease by subjective global assessment.

To investigate the prevalence of malnutrition in patients with inflammatory bowel disease (IBD) by subjective global assessment (SGA) and the effects of oral nutritional support on the clinical parameters, consumption of energy, macronutrients and fiber intake in the Study and Control groups, prospectively. A total of 38 (28 Male; 10 Female) hospitalized patients with moderate or severe IBD (13 with Crohn's disease (CD); 25 with Ulcerative colitis (UC)) were included. At stage 1, the disease severity, clinical symptoms and, signs, food consumption and nutritional status by using subjective global assessment (SGA) were recorded. At stage 2, the patients were blindly randomized into a Study Group and Controls. In the Study Group, a standard enteral product was added into the regulated hospital diets, but for the Controls, deficits were regulated by only hospital diets for 3 weeks. the independent variables were the group, the disease and its activity, age, Body body mass index (BMI), weight loss history, the hospitalization period; the dependent variables were SGA, bowel movements, change in nutritional status, disease severity, clinical findings, and also consumption of macronutrients. Prevalance of malnutrition (SGA-B or SGA-C) for all the patients was 92.1% at the beginning and 71.1% at the end of study. Improvements in disease activity score for the patients with UC were statistically significant in both the Study Group and the Controls (p=0.006 for the Study Group and p=0.001 for the Controls, respectively). Macronutrients, total and water soluble fiber consumption levels improved, with statistically significant differences for all the groups. The prevalence of malnutrition is a major problem in patients with IBD. Not only the regulation of hospital food, but also enteral nutritional support, improved their levels of malnutrition, as well as their energy, macronutrients, and fiber consumption, and SGA is an easy method for nutritional monitoring.

The effect of enteral nutrition support with low carbohydrate on blood gas analysis indexes and serum inflammatory factors of patients with AECOPD

Objective To observe effect of enteral nutrition support with low carbohydrate on blood gas analysis indexes and serum inflammatory factors of patients with AECOPD.Methods Patients in test group and control group were fed by nasal tube for 7 days,with low carbohydrate for test group and normal homogenate for control group.Detected and analyzed levels of blood gas analysis indexes,IL-6,TNF-α,MyD88 and CRP of patients in two groups.Results 7 days after treatment,the level of PaO2 in test group was higher than that in control group,the levels of PaCO2,IL-6,TNF-α,MyD88,CRP in test group were lower than those in control group,with statistically significant differences between two groups (P ＜ 0.05).Conclusion Enteral nutrition support with low carbohydrate can improve ventilation function and reduce inflammation levels of patients with AECOPD. Key words: Enteral nutrition support with low carbohydrate; Acute exacerbation of chronic obstructive pulmonary disease(AECOPD); Blood gas analysis; Inflammatory factor

The therapeutic effect of enteral nutrition support on chronic cardiac failure of rats

Objective To study the therapeutic effect and mechanism of enteral nutrition support for treatment of chronic cardiac failure of rats.Methods Ligature of abdominal aorta was used to prepare SD rat model of chronic cardiac failure.The rat models of cardiac failure were randomly (random number) divided into three groups:conventional therapy group,conventional therapy plus enteral nutrition support group and non-therapy group.The rats in conventional therapy group were administrated with routinely used drugs for chronic cardiac failure.The rats in conventional therapy plus enteral nutrition support group were treated with conventionally used medicine plus enteral nutrition liquid.The rats in non-therapy group were given the same amounts of dummy medicine and normal saline.Ultrasonic cardiography,ELISA for detection of atrial natriuretic peptide (BNP) and examination of pathological change in myocardium tissues after HE staining were carried out for comparison of cardiac function of rats with chronic heart failure between pre-and post-treatment.Results The commonly used drug enabled the heart of rats with chronic heart failure to elevate the LVFS (left ventricular fraction shortening) and LVEF (left ventricular ejection fraction) levels (q=3.59,P＜0.05; q=4.01,P＜0.05),to decrease the BNP in blood plasma (u=2.285,P＜0.05) and to lessen the injury of myocardial tissue (u =2.332,P ＜ 0.05).However,compare to the chronic cardiac failure rats administrated with commonly used drug,the chronic cardiac failure rats treated by combination of the commonly used drug and enteral nutrition liquid presented significantly higher LVFS and LVEF levels (q =4.34,P ＜ 0.05 ; q =3.98,P ＜ 0.05),lower plasma BNP level (u =2.548,P ＜0.02) and milder injury of myocardial tissue (u=2.631,P＜0.02).Conclusions The commonly used drug plus enteral nutrition support promotes in higher efficiency the heart function of chronic cardiac failure rats,suggesting that this nutrition support can be used as an adjuvant therapy for patients with chronic cardiac failure in clinic. Key words: Chronic cardiac failure; Enteral nutritional supportive therapy; Rats; Brain natriuretic peptide ; Ventricular function; Ultrasonic cardiogram; HE staining; Curative effect