An indoor air purification system coupled with adsorption and heat storage was designed based on a prefabricated building, which has the advantages of high purification efficiency, does not take up indoor space and does not require additional power consumption. It has been shown that the relative humidity has a significant impact on the purification effect of particulate matter. Using sponge activated carbon as adsorption material, the effect of different relative humidity on the purification efficiency of PM2.5 and PM10 was experimentally studied, and the purification effect of the purification system on PM2.5 and PM10 under various relative humidity conditions was analyzed. The results show that in the relative humidity interval of 20%-70%, with the increase of relative humidity, the sponge activated carbon purification system shows an increasing trend in the purification efficiency of PM2.5, and the effect on the purification efficiency of PM10 is not obvious.