Effects Of Different Modes Research Articles

The enhancement detection method based on the Fabry–Pérot cavity using terahertz frequency-domain spectroscopy

This article demonstrates a simple, efficient, and low-cost gas detection method for gases with absorption peaks in the terahertz range. A modes-adjustable Fabry–Pérot cavity is designed. By adjusting the length of the cavity, the center resonant frequency of the cavity can be coupled to the gas absorption peak. This kind of coupling can greatly enhance gas detection. To detect gas absorption peaks, we choose terahertz frequency domain spectroscopy (THz-FDS), whose frequency resolution can be up to the MHz level. Vapor is selected to verify the coupling phenomenon. The resonant frequency of the cavity is modified to couple to 0.56 THz, the absorption peak of vapor. Experiments are conducted at different humidity levels, the humidity is controlled by the supersaturated salt solution. Results indicate that at a humidity level of 15 %, the coupling effect can enhance the detectability of vapor by approximately 167 %, and this enhancement effect diminishes as humidity increases. We analyze the effect of different modes on the coupling and find that the high modes can make the coupling easier, but have little effect on the enhancement. Furthermore, the method is used to detect biomolecule-α-tyrosine to ensure it has wide applicability. This method can be used to detect substances with absorption peaks in the THz regime, especially for low-concentration gas.

Effectiveness of Online and Offline Learning: Comparative Study at English Education Department University of Mataram

This thesis aims to find the effective implementations between online and offline learning and determine which learning mode is effective at the University of Mataram. This study focused on comparing the effectiveness of different modes of learning implementations based on students’ perceptions. The subject of this study is the students at the English Education Department University of Mataram who had experience with online, offline, and blended learning in the class. The researcher analyzes data using mixed methods (qualitative and quantitative) according to Sugiyono (2017). In this thesis researcher chose the sixth semester, that frequently used between online and offline learning with five classes, and chose one class to observe consisting of 27 students, the researchers collected the data using two different instruments, there are questionnaires researcher collected data related to the effectiveness of online and offline learning using a closed-ended questionnaire and the second one is an interview that’s researcher interviewed some students to know about students' perceptions of online and offline learning in the class. The result that the researcher compared was that offline learning was perceived to be a more effective learning mode this is shown by the higher agreement percentage in key aspects such as syllabus (58.3%), teaching method (44.4%), and discussion (48.1%). Moreover, the implementation of offline and online learning has various aspects in the learning process that can help a teacher and researcher in the future explore more pedagogical strategies and instruction design principles that promote effective offline and online learning experiences.

A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms.

Rhinovirus (RV) infection is a major cause of common colds and asthma exacerbations, with no antiviral drug available. Curcumin exhibits broad-spectrum antiviral activities, but its therapeutic effect is limited by a poor pharmacokinetics profile. Curcumin-like diarylpentanoid analogs, particularly 2-benzoyl-6-(3,4-dihydroxybenzylidene)cyclohexen-1-ol (BDHBC) and 5-(3,4-dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one (DHHPD), have better solubility and stability compared to curcumin. Therefore, this study aims to evaluate and compare the antiviral effects of curcumin, BDHBC, and DHHPD in an in vitro model of RV infection. The inhibitory effects on RV-16 infection in H1 HeLa cells were assessed using cytopathic effect (CPE) reduction assay, virus yield reduction assay, RT-qPCR, and Western blot. Antiviral effects in different modes of treatment (pre-, co-, and post-treatment) were also compared. Additionally, intercellular adhesion molecule 1 (ICAM-1) expression, RV binding, and infectivity were measured with Western blot, flow cytometry, and virucidal assay, respectively. When used as a post-treatment, BDHBC (EC50: 4.19µM; SI: 8.32) demonstrated stronger antiviral potential on RV-16 compared to DHHPD (EC50: 18.24µM; SI: 1.82) and curcumin (less than 50% inhibition). BDHBC also showed the strongest inhibitory effect on RV-induced CPE, virus yield, vRNA, and viral proteins (P1, VP0, and VP2). Furthermore, BDHBC pre-treatment has a prophylactic effect against RV infection, which was attributed to reduced basal expression of ICAM-1. However, it did not affect virus binding, but exerted virucidal activity on RV-16, contributing to its antiviral effect during co-treatment. BDHBC exhibits multiple antiviral mechanisms against RV infection and thus could be a potential antiviral agent for RV.

Study of multiplicity dependence of heavy flavor production in pp collisions using rope hadronization mechanism

The multiplicity dependence of the production of the charm mesons in pp collisions at [Formula: see text][Formula: see text]TeV and 13[Formula: see text]TeV as measured by ALICE experiment has been investigated using Pythia 8 event generator by studying the effect of various processes at partonic level such as the effect of different modes of color reconnections and rope hadronization. The relative yields ([Formula: see text]) of D-mesons and [Formula: see text] as a function of relative charged particle multiplicity for various transverse momentum ([Formula: see text]) ranges as measured by the ALICE experiment are in reasonable agreement with the estimations of Pythia 8 model within the framework of microscopic processes. The relative yields of B mesons for various [Formula: see text] intervals ([Formula: see text][Formula: see text]GeV/c) have also been predicted in pp collisions at [Formula: see text][Formula: see text]TeV and [Formula: see text][Formula: see text]TeV.

Donor human milk treated by high-pressure processing improves the body growth of growth-restricted mice pups.

Pasteurized human donor milk (DM) is frequently used for feeding preterm newborns and extrauterine growth-restricted (EUGR) infants. Most human milk banks performed a pasteurization of DM using the standard method of Holder pasteurization (HoP) which consists of heating milk at 62.5°C for 30 min. High hydrostatic pressure (HHP) processing was proposed to be an innovative nonthermal method to pasteurize DM. However, the effect of different modes of DM pasteurization on body growth, intestinal maturation, and microbiota has never been investigated in vivo during the lactation. We aimed to study these effects in postnatally growth-restricted (PNGR) mice pups daily supplemented with HoP-DM or HHP-DM. PNGR was induced by increasing the number of pups per litter (15 pups/mother) at postnatal Day 4 (PND4). From PND8 to PND20, mice pups were supplemented with HoP-DM or HHP-DM. At PND21, the intestinal permeability was measured in vivo, the intestinal mucosal histology, gut microbiota, and short-chain fatty acids (SCFAs) level were analyzed. HHP-DM pups displayed a significantly higher body weight gain than HoP-DM pups during lactation. At PND21, these two types of human milk supplementations did not differentially alter intestinal morphology and permeability, the gene-expression level of several mucosal intestinal markers, gut microbiota, and the caecal SCFAs level. Our data suggest that HHP could be an attractive alternative to HoP and that HHP-DM may ensure a better body growth of preterm and/or EUGR infants.

Different modes of ankle pump exercise to prevent PICC-related thrombosis through femoral vein.

To explore the preventive effect of different modes of ankle pump exercise on femoral vein PICC catheter-related thrombosis. Convenient sampling method was used to select 172 patients with lung cancer with PICC catheterization through femoral vein admitted to West China Hospital of Sichuan University as the observation group and control group. Comfort angle ankle pump exercise mode and maximum angle ankle pump exercise mode were adopted. We have compared the differences in the incidence of catheter-related thrombosis, unplanned catheter removal, fatigue score, and catheter retention time between two groups of patients. The incidence of catheter-related thrombosis, unplanned catheter removal, fatigue score, and catheter retention time were statistically significant (p < .05) in both groups of patients. The maximum angle ankle pump exercise mode can reduce the incidence of catheter-related thrombosis and unplanned catheter removal in patients with lung cancer with PICC catheterization through femoral vein, increase catheter retention time, but it can easily cause patient fatigue. In clinical practice, patient tolerance should be considered.

Factors Influencing the Visualization of Fallopian Tubes in Hysterosalpingo-Contrast Sonography (HyCoSy)-The Value of Multimodal HyCoSy in Visualizing the Fallopian Tubes.

Four-dimensional hysterosalpingo-contrast sonography (4D-HyCoSy) can non-invasively evaluate the patency of the fallopian tubes and is increasingly used in clinical practice. However, some factors may lead to false-positive diagnoses. This study aims to analyze the factors affecting clear imaging of the fallopian tubes in 4D-HyCoSy and explore methods to improve the quality of fallopian tube imaging. A total of 118 patients were enrolled in this retrospective study. After injecting the SonoVue into the uterine cavity, three modes of HyCoSy were completed in sequence: 4D-HyCoSy, 2D-HyCoSy, and second harmonic imaging (SHI). Participants were divided into two groups: the easy visualization group (fallopian tubes could be visualized using only 4D-HyCoSy) and the difficult visualization group (a multimodal combination was required for visualization). The position of the uterus, the relationship between the ovaries and the uterus, endometrial thickness, time of catheterization in the uterine cavity, presence or absence of lesions in the uterine cavity, whether intestinal gas covers the fallopian tubes and the imaging effect of different modes on the fallopian tubes was analyzed, to determine the key factors affecting the clear imaging of the fallopian tubes. The positional relationship between the ovary and the uterus (OR = 4.711, 95% CI: 1.322-19.77, P = 0.023), the positioning of the uterus (OR = 3.843, 95% CI: 1.129-15.26, P = 0.04), endometrial thickness (OR = 3.985, 95% CI: 1.168-15.99, P = 0.036), and the duration of intrauterine catheter placement (OR = 3.547, 95% CI: 1.042-13.52, P = 0.05) were independent factors that affecting difficulty in visualizing the fallopian tubes. Uterine position, the positional relationship between the ovary and the uterus, endometrial thickness, and the time of catheter insertion are factors that affect visualizing the fallopian tubes during 4D-HyCoSy. The combination of multimodal imaging, especially the combination of 4D-HyCoSy with SHI mode, can help improve the quality of fallopian tube visualization.

Comparative Study on the Effect of Different Modes of Administration of Ambroxol Hydrochloride in the Treatment of Pediatric Respiratory Diseases

Objective: To investigate the comparison of the effects of intravenous infusion of Ambroxol Hydrochloride and nebulized inhalation in the treatment of pediatric respiratory diseases. Methods: 188 children with respiratory diseases admitted to the pediatrics department of the hospital from September 2022 to March 2024 were selected as the study subjects, and were randomly divided into the control group (n = 41) and the observation group (n = 41) according to the random number table method. Both groups of patients were first treated with conventional treatment, and based on conventional treatment, the control group was treated with intravenous infusion of Ambroxol Hydrochloride, and the observation group was treated with nebulized inhalation of Ambroxol Hydrochloride. The general information, clinical symptom improvement time, oxygen therapy time, sputum aspiration frequency, hospitalization time, and the occurrence of adverse reactions were observed in the two groups. Results: The baseline data of the two groups of patients were not statistically significant (P &gt; 0.05); the disappearance time of clinical symptoms such as cough, lung rales, and shortness of breath in the observation group was shorter than that in the control group (t = 8.739, t = 10.108, t = 19.448, P &lt; 0.001); the time of oxygen therapy, number of sputum aspirations, and hospital stay of the patients in the observation group were significantly shorter than that of the control group (t = 10.593, t = 10.665, t = 14.673, all P &lt; 0.001); the total incidence of adverse reactions in patients in the observation group (3/3.18%) was significantly lower than that in the control group (14/14.89%) (x2 = 7.825, P = 0.005 &lt; 0.01). Conclusion: In the treatment of pediatric respiratory diseases with Ambroxol Hydrochloride, nebulized inhalation has better efficacy than intravenous drip, and can better improve the clinical symptoms and reduce the side effects in children.

Impact of Pressure Targeted Modes of Ventilation on Diaphragmatic Function as Assessed Using Ultrasonography in Critically Ill Patients with Cerebral Insult

Abstract Background Mechanical ventilation (MV) causes diaphragmatic atrophy and reduces diaphragmatic efficiency. Patients with diaphragmatic dysfunction (DD) have longer MV durations and intensive care unit (ICU) stay. There is currently a scarcity of data on the effect of different modes of MV on diaphragmatic function and ultrasound-guided assessment of diaphragmatic efficiency. Methodology Sixty mechanically ventilated patients were randomly divided into four equal groups (15 each), patients were ventilated using either Assist Control Pressure Controlled mode (ACPC group)(Group A), Synchronized Intermittent Mandatory Ventilation Pressure Controlled mode (SIMV)(Group S), Bi-level Positive Airway Pressure mode (BiPAP)(Group B), or Pressure Support Ventilation mode (PSV)(Group P). The primary outcomes were diaphragmatic motion &amp; structure in terms of Diaphragmatic Excursion (DE) &amp; Diaphragmatic Thickness Fraction (DTF) respectively. The duration of the ICU stay was the secondary outcome. Results The PSV group had the highest DE indicating better diaphragmatic function. In addition, MV for longer durations led to diaphragmatic thinning and decreased DTF resulting in DD. Conclusion Among the various modes of ventilation employed in the study, PSV was found to be the mode with the lowest risk of DD. Trial Registry PACTR202112653971335.

Effects of different exercise modes and intensities on cognitive performance, adult hippocampal neurogenesis, and synaptic plasticity in mice.

Exercise can induce beneficial improvements in cognition. However, the effects of different modes and intensities of exercise have yet to be explored in detail. This study aimed to identify the effects of different exercise modes (aerobic and resistance) and intensities (low and high) on cognitive performance, adult hippocampal neurogenesis and synaptic plasticity in mice. A total of 40 C57BL/6J mice were randomised into 5 groups (n = 8 mice per group): control, low-intensity aerobic exercise, high-intensity aerobic exercise, low-intensity resistance exercise, and high-intensity resistance exercise. The aerobic exercise groups underwent treadmill training, while the resistance exercise groups underwent ladder climbing training. At the end of the exercise period, cognitive performance was assessed by the Y-maze and Barnes maze. In addition, adult hippocampal neurogenesis was evaluated immunohistochemically by 5-bromo-2'-deoxyuridine (BrdU)/ neuronal nuclei (NeuN) co-labeling. The levels of synaptic plasticity-related proteins in the hippocampus, including synaptophysin (SYP) and postsynaptic density protein 95 (PSD-95), were analyzed by western blotting. Our results showed no significant differences in cognitive performance among the groups. However, high-intensity aerobic exercise significantly increased hippocampal adult neurogenesis relative to the control. A trend towards increased adult neurogenesis was observed in the low-intensity aerobic group compared to the control group. No significant changes in synaptic plasticity were observed among all groups. Our results indicate that high-intensity aerobic exercise may be the most potent stimulator of adult hippocampal neurogenesis.

Exercise Prescription in Individuals with Prehypertension and Hypertension: Systematic Review and Meta-Analysis.

The prevalence of prehypertension and hypertension has been increasing over the years, and is closely related to cardiovascular and cerebrovascular diseases. Exercise is an effective method of lifestyle intervention, and it aims to lower blood pressure and control other risks. Studies have shown that different modes of exercise have varying effects on blood pressure, and individuals with prehypertension or hypertension need to carry out this intervention by using personalized modes of exercise. We conducted a systematic review and meta-analysis to evaluate the effects of different modes of exercise regimens on systolic blood pressure, diastolic blood pressure and heart rate in individuals with high-normal blood pressure and hypertension. We included 27 trials, and 2731 individuals were under 8 exercise regimens. Stata12.0 statistical software was used for statistical analysis. Heat pools significantly reduced systolic blood pressure (SBP) by 15.62 mmHg (95% confidence interval [CI]: -23.83, -7.41), and cycling reduced SBP by 14.76 mmHg (-17.04, -12.48). Two to three types of aerobic exercise performed at the same time also significantly reduced diastolic blood pressure (DBP) by 5.61 mmHg (-7.71, -3.52), and isometric handgrip training exercise reduced DBP by 5.57 mmHg (-7.48, -3.66). Cycling also significantly reduced heart rate (HR) by 9.57 beats/minute (-11.25, -7.90). The existing literature suggests that different types of exercise can effectively reduce the levels of SBP, DBP and HR in individuals with prehypertension or hypertension.

Anxiety-Reducing Effects of Lavender Essential Oil Inhalation: A Systematic Review.

Anxiety disorders are the most prevalent and disabling mental disorders, causing health-related burdens. With the increasing demand for and interest in safe and acceptable anxiolytics, several studies report the anxiolytic effects of lavender aromatherapy, providing evidence of its physiological and psychological effects. However, existing reviews comprehensively cover the effects of different modes of delivering aromatherapy. Therefore, this review assesses the efficacy of lavender essential oil inhalation in reducing anxiety. The titles and abstracts of relevant articles published over the last five years were searched in PubMed, Web of Science, and Scopus databases. This review only included clinical trials that utilized lavender inhalation for anxiety treatment. Eleven studies comprising 972 participants were included. Of these, 10 reported significantly decreased anxiety levels after lavender oil inhalation. The physiological measures of vital signs, including blood pressure, heart rate, respiratory rate, pulse, and saturation, were conducted in three trials, showing that lavender oil inhalation could physiologically affect anxiety levels. Lavender oil inhalation is a safe and feasible anxiolytic intervention for treating people with diverse types of anxiety. Data from further studies with a high-quality design and accurate information are necessary to confirm the validity of these findings and elucidate the anxiety-reducing mechanisms of lavender inhalation.

Short-chain fatty acids levels in human milk are not affected by holder pasteurization and high hydrostatic pressure processing.

Sterilized donor milk (DM) is frequently used for feeding preterm infants. To date, the effect of different modes of DM sterilization on short-chain fatty acids (SCFAs) remains unknown. We aimed to quantify SCFAs in DM samples after two types of milk sterilization: the Holder pasteurization (HoP) and a high hydrostatic pressure (HP) processing. Eight pooled DM samples were sterilized by HoP (62.5°C for 30 min) or processed by HP (350 MPa at 38°C). Raw DM was used as control. Six SCFAs were quantified by gas chromatography/mass spectrometry. Compared to raw milk, both HoP and HP treatment did not significantly modulate the concentration of acetate, butyrate, propionate and isovalerate in DM. Valerate and isobutyrate were undetectable in DM samples. In conclusion, both HoP and HP processing preserved milk SCFAs at their initial levels in raw human milk.

Joint Moment Responses to Different Modes of Augmented Visual Feedback of Joint Kinematics during Two-Legged Squat Training

This study examined the effects of different modes of augmented visual feedback of joint kinematics on the emerging joint moment patterns during the two-legged squat maneuver. Training with augmented visual feedback supports improved kinematic performance of maneuvers related to sports or daily activities. Despite being representative of intrinsic motor actions, joint moments are not traditionally evaluated with kinematic feedback training. Furthermore, stabilizing joint moment patterns with physical training is beneficial to rehabilitating joint-level function (e.g., targeted strengthening and conditioning of muscles articulating that joint). Participants were presented with different modes of augmented visual feedback to track a target squat-motion trajectory. The feedback modes varied along features of complexity (i.e., number of segment trajectories shown) and body representation (i.e., trajectories shown as sinusoids versus dynamic stick-figure avatars). Our results indicated that mean values and variability (trial-to-trial standard deviations) of joint moments are significantly (p &lt; 0.05) altered depending on the visual feedback features being applied, the specific joint (ankle, knee, hip), and the squat movement phase (early, middle, or late time window). This study should incentivize more optimal delivery of visual guidance during rehabilitative training with computerized interfaces (e.g., virtual reality).

Effect of Honey Bee &lt;i&gt;Apis mellifera&lt;/i&gt; L. Pollination on Oilseed Rape

An experiment was conducted to survey insect visitors and the effect of different modes of pollination on quantity of oilseed rape. Survey revealed that a wide range of insect species, including honey bees, and hover flies, house fly and ensign fly were frequent on oilseed rape flowers where honey bees (Apis dorsata and Apis mellifera) were dominant. Effect of pollination revealed that in bee pollinated (BP) plants the number of pods/ plant, number of seeds/ pod, weight of 1000 seeds (g) and yield/ ha were 16.38, 20.18, 6.75 and 14.27% higher than open/naturally pollinated (NP) plants, respectively. Without (WP) pollinators the number of pods/ plant, number of seeds/ pod, weight of 1000 seeds (g) and yield/ ha were the 19.38, 37.05, 8.10 and 32.63% lower than naturally pollinated (NP) plants, respectively. Bee pollination is the most effective and cheaper device for seed production in rapeseed and mustard.

Deposit? Yes, please! The effect of different modes of assigning reward- and deposit-based financial incentives on effort

Abstract The effectiveness and uptake of financial incentives can differ substantially between reward- and deposit-based incentives. Therefore, it is unclear to whom and how different incentives should be assigned. In this study, the effect of different modes of assigning reward- and deposit-based financial incentives on effort is explored in a two-session experiment. First, students’ (n = 228, recruited online) discounting, loss aversion and willingness to pay a deposit were elicited. Second, an incentivized real-effort task was completed (n = 171, 25% drop-out). Two modes of assigning reward- or deposit-based financial incentives were compared: random assignment and ‘nudged’ assignment – assignment based on respondent characteristics allowing opting out. Our results show that respondents receiving nudged assignment earned more and persisted longer on the real-effort task than respondents randomly assigned to incentives. We find no differences in effectiveness between reward-based or deposit-based incentives. Overall, 39% of respondents in the nudged assignment mode followed-up the advice to take deposit-based incentives. The effect of deposit-based incentives was larger for the respondents who followed-up the advice than for respondents that randomly received deposit-based incentives. Overall, these findings suggest that nudged assignment may increase incentives’ effect on effort. Future work should extend this approach to other contexts (e.g., behaviour change).

Effect of exercise mode specificity on quality of life in prostate cancer patients undergoing androgen suppression.

72 Background: Androgen deprivation therapy (ADT) is accompanied by a range of adverse effects including those of the musculoskeletal, metabolic, and cardiovascular systems, as well as compromised functioning and quality of life (QoL). Exercise has been shown to be an effective countermeasure to a number of these toxicities, although the effects of different modes or prescriptions on self-report QoL is unclear. Here we report the effects from a yearlong trial of 3 different exercise prescriptions involving aerobic, resistance, and impact loading modes on QoL in men with prostate cancer undergoing ADT. Methods: One hundred and fifty-four prostate cancer patients (43-90 yrs, BMI 28.7 ± 4.1) on ADT (Mdn 3 mths, IQR 2.0-4.0 mths) were randomized to exercise targeting the musculoskeletal system (impact loading + resistance training; ILRT, n=57) supervised for 12 months, cardiovascular and muscular systems (aerobic + resistance training; ART, n=50) supervised for 6 months followed by a 6-month home program, or delayed aerobic exercise (DelAer, n=47) receiving exercise information for 6 months followed by 6 months supervised stationary cycling exercise. Supervised exercise was undertaken twice weekly at a moderate intensity. QoL domains were assessed at baseline, 6, and 12 months using the Short Form-36 questionnaire. Results: There were no significant differences among groups in QoL domains at baseline. Following exercise there was a significant group x time interaction (p &lt; 0.05) for the domain role physical and the physical health composite score with increases at 12 months for ILRT and DelAer. There was also a significant time effect (p &lt; 0.001) for improvements in physical functioning, general health, vitality, and mental health, and also bodily pain (p = 0.037), with no between-group differences. Patients in the lowest tertile for QoL at baseline improved the most with exercise (Ptrend &lt; 0.001). Conclusions: Different exercise modes had similar effects on improving QoL in patients with prostate cancer undergoing ADT. Importantly, those with the lowest QoL derived the greatest benefits from exercise. Recommending patients on ADT to undertake exercise, regardless of mode, will help to preserve or improve quality of life. Clinical trial information: ACTRN12609000200280 .

Machining grade 4 titanium alloy by minimum quantity lubrication for enhanced sustainable manufacturing

AbstractMachining is a widely used class of industrial manufacturing operation, wherein cutting fluids play a vital role in terms of machining accurate dimensional quality objects due to their cooling, lubricant, and chip removal abilities. Although certain advanced cutting fluids have changed the manufacturing industry for the better, there are some environmental concerns associated with some of these fluids. The use and disposal of cutting fluids may be costly and subjected to stringent government laws. Hence, the ever-growing research conducted on environmentally friendly cutting fluids may lead to enhanced sustainable manufacturing. The aim of this investigation is therefore to investigate the viability of minimum quantity lubrication (MQL) during machining of titanium alloys with specific focus on the commercially pure grades (grade 4). A comparative study was conducted in order to establish the effects of different modes of lubrication, i.e., dry, wet, and MQL machining on titanium.

The comparison of the repair bond strength of the composite resin to direct and indirect composite restorations with different surface preparations.

Indirect restorations have been employed in restorative dentistry to solve some of the drawbacks of direct restorations. The aim of this study was to evaluate the effect of different modes of a universal adhesive resin on the repair capacity of two indirect resin composites and a direct resin composite. Indirect composite resins (Ceramage and Gradia Plus) and a direct composite resin (Filtek Z250) were prepared in a plastic mold with a height and diameter of 2-mm and 6-mm, respectively. Composite blocks were thermocycled (5000 cycles, 5°C-55°C). Then, according to their surface treatments, composite blocks were categorized into six-groups: Group 1: ER (etch&rinse), Group 2: SE (self-etch), Group 3: Bur+ER (bur+etch&rinse), Group 4: Bur+SE (bur+self-etch), Group 5: Bur+Silane+ER (bur+silane+etch&rinse), Group 6: Bur+Silane+SE (bur+silane+self-etch), respectively. After surface treatments and adhesive application for bonding with a direct resin composite, all groups were then thermocycled before performing shear-bond-strength-test. Failure modes were evaluated using a stereomicroscope. Data were analyzed by two-way-ANOVA and Bonferroni-test (P<0.05). The highest bond-strength values were obtained for Bur+Silane+SE groups, while the lowest values were obtained for the Bur+Silane+ER groups for all materials. Statistically significant differences were observed between the Bur+Silane+ER group and ER, Bur+ER and Bur+Silane+SE groups in Gradia Plus (P<0.05). The self-etch-mode of the universal-adhesive and silane applications led to the increase in the repair-strength of the adhesive in the Filtek Z250 and Ceramage. The self-etch-mode of the universal-adhesive might be used to reduce adhesive-application-steps in the clinical repair procedures.

Effects of different modes and intensities of exercise on longevity proteins in middle-aged mouse skeletal muscle.

Physical exercise represents one of the most effective approaches to anti-aging. The goal of this study was to verify the effects of different modes and intensities of exercise on longevity proteins in the skeletal muscle in midlife. Middle-aged mice were trained in aerobic or resistance exercise for 8 weeks, and the changes in sirtuin 1 (SIRT1), adenosine monophosphate-activated kinase (AMPK), and mammalian target of rapamycin (mTOR) pathways in the skeletal muscle were evaluated by western blotting. Long-term exercise had no effects on skeletal muscle SIRT1 abundance, whereas high-intensity aerobic exercise increased AMPK phosphorylation and peroxisome proliferator-activated receptor-γcoactivator-1α (PGC-1α). Low-intensity resistance exercise facilitated Akt/mTOR/p70 ribosomal protein kinase S6 (p70S6K) signaling but did not induce muscle hypertrophy. Conversely, high-intensity resistance exercise stimulated muscle hypertrophy without phosphorylation of mTOR signaling-related proteins. These results suggest the importance of setting exercise modes and intensities for anti-aging in midlife.