Effects Of Different Durations Research Articles

Acute and Prolonged Effects of Stretching on Shear Modulus of the Pectoralis Minor Muscle.

Increased muscle stiffness of the pectoralis minor (PMi) could deteriorate shoulder function. Stretching is useful for maintaining and improving muscle stiffness in rehabilitation and sport practice. However, the acute and prolonged effect of stretching on the PMi muscle stiffness is unclear due to limited methodology for assessing individual muscle stiffness. Using shear wave elastography, we explored the responses of shear modulus to stretching in the PMi over time. The first experiment (n = 20) aimed to clarify the acute change in the shear modulus during stretching. The shear modulus was measured at intervals of 30 s × 10 sets. The second experiment (n = 16) aimed to observe and compare the prolonged effect of different durations of stretching on the shear modulus. Short and long stretching duration groups underwent 30s × 1 set and 30s × 10 sets, respectively. The assessments of shear modulus were conducted before, immediately after, and at 5, 10, and 15 min post-stretching. In experiment I, the shear modulus decreased immediately after a bout (30 s) of stretching (p < 0.001, change: -2.3 kPa, effect size: r = 0.72) and further decreased after 3 repetitions (i.e., 90 s) of stretching (p = 0.03, change: -1.0 kPa, effect size: r = 0.53). In experiment II, the change in the shear modulus after stretching was greater in the long duration group than in the short duration group (p = 0.013, group mean difference: -2.5 kPa, partial η2 = 0.36). The shear modulus of PMi decreased immediately after stretching, and stretching for a long duration was promising to maintain the decreased shear modulus. The acute and prolonged effects on the PMi shear modulus provide information relevant to minimum and persistent stretching time in rehabilitation and sport practice.

Influence of coloring liquid immersion on flexural strength, Vickers hardness, and color of zirconia

Statement of problemZirconia is a widely used restorative material, yet its white color does not meet esthetic requirements and coloring is needed. However, the effects of different durations of coloring have not been thoroughly investigated. PurposeThe purpose of this in vitro study was to evaluate the effects of coloring liquid immersion of different durations on the flexural strength, Vickers hardness, and color of zirconia. Material and methodsFifty bar-shaped and 60 disk-shaped zirconia specimens were milled from nonshaded (Copran Zri) and preshaded (Copran Zri Precoloured Medium) disks by using a computer-aided design and computer-aided manufacturing (CAD-CAM) system. Preshaded specimens were assigned to the group PS and received no further immersion. Nonshaded specimens were divided into 4 subgroups as per immersion time in coloring liquid (Copran Color A2 Shade): control (C; no immersion), G45 (45 seconds of immersion), G90 (90 seconds of immersion), and G135 (135 seconds of immersion). Bar-shaped specimens were subjected to a 3-point flexural strength test by using a universal testing machine (Lloyd LRX), following the International Organization for Standardization (ISO) 6872:2015 specification. Color coordinates of disk-shaped specimens were measured with a spectrophotometer (VITA Easyshade Advance 4.0) over a gray background. Color differences were calculated by using both CIE76 and CIEDE2000 formulas, followed by a comparison of obtained values with perceptibility (CIE76: 3.7, CIEDE2000: 0.8) and acceptability (CIE76: 6.8, CIEDE2000: 1.8) thresholds of each formula. Subsequently, Vickers hardness measurements were conducted. The data were statistically analyzed by using the Shapiro-Wilk test, 1-way ANOVA, and the Tukey HSD test (α=.05). ResultsImmersing zirconia specimens in coloring liquid decreased the flexural strength and hardness values, as group C presented the highest values for both parameters. In addition, prolonged duration had a negative effect on mechanical properties. The flexural strength of groups PS and G45 (P=.993) and groups G90 and G135 (P=.999) was statistically similar. For Vickers hardness, group G135 presented the lowest values with the difference between groups G90 and G135 being statistically similar (P=.061). Color differences among groups varied from 2.49 to 27.33 for ΔE∗, whereas ΔE00 values ranged from 0.58 to 8.26. Compared with group C, ΔE∗ values of all shaded specimens exceeded the acceptability threshold of 6.8. The color difference between each group was higher than the acceptability threshold values of both ΔE∗ and ΔE00 except for groups G45 and PS. ConclusionsColored zirconia specimens had lower flexural strength and Vickers hardness values than nonshaded specimens, regardless of the immersion time or coloring technique.

Duration and choices of prophylactic anticonvulsants in subarachnoid hemorrhage: a systematic review and meta-analysis.

The use of prophylactic anticonvulsants among patients with subarachnoid hemorrhage (SAH) is controversial. We sought to assess the effectiveness of different durations of prophylactic antiepileptic drug (AED) use among SAH patients. We searched the MEDLINE, Embase, Cochrane, and ClinicalTrials.gov databases until March 1, 2020. Randomized controlled trials or observational studies comparing different durations or different drugs were selected. The primary outcome was poor clinical outcomes. The secondary outcome was in-hospital seizure. Bayesian network meta-analysis was also performed to indirectly compare the effectiveness of different prophylaxes. A total of 5 papers were included. Three studies with a total of 959 patients were included in the analysis of the primary outcome; the results showed that long-term exposure to prophylactic AEDs (more than 3days) led to poor clinical outcomes (OR 1.55; 95% CI 1.01-2.39; p= 0.045). Four studies with 1024 patients were included in the analysis of the secondary outcome; the results showed no association between the duration of prophylactic AED use and the occurrence of in-hospital seizures (OR 0.62; 95% CI 0.18-2.15; p= 0.447). In the network meta-analysis, no significant difference was found among the four different prophylaxes. Our findings suggested that, when compared with the short-term use, the long-term use of prophylactic AEDs in SAH patients has a similar effect on in-hospital seizure prevention but is associated with poor clinical outcomes. However, these findings were based on a small number of available studies with obvious heterogeneity in study design and different prescription regimens. Further well-designed studies are warranted to elucidate these questions.

Acute Effect of Different Duration of Foam Rolling Protocols on Muscle Thickness, Pain Pressure Threshold, and Volume Load on Multiple Sets of Knee Extension

Acute Effect of Different Duration of Foam Rolling Protocols on Muscle Thickness, Pain Pressure Threshold, and Volume Load on Multiple Sets of Knee Extension

Physiological effects of transport duration on stress biomarkers and meat quality of medium-growing Yellow broiler chickens

Pre-slaughter transport exerts negative effects on broilers’ welfare, meat yield, and meat quality, but little is known about the effect of transport on medium-growing broiler chickens. This study aimed at evaluating the effects of different durations of transport (0, 0.5, 1, 2, and 3h) on stress biomarkers and meat quality of medium-growing Yellow-feathered broiler chickens. One hundred and eighty Chinese Yellow-feathered broilers aged 75days (marketing age), of 2.02kg average BW, were allotted into five groups; each group contained six replicates (six birds/replicate (crate)). Each crate with dimensions 74×55×27cm (length × width × height) was loaded with six birds, that is, 30kg live BW/m2 crate. The tested transport durations increased BW loss (linear, P<0.01), plasma concentrations of ACTH (linear, P<0.10), cortisol and corticosterone (quadratic, P<0.05), and activity of glutathione peroxidase (linear, P<0.05), whereas plasma glucose was not affected. In breast muscle, contents of glycogen, lactic acid, malondialdehyde, and reduced glutathione were not affected (P>0.05), but total antioxidant capacity decreased (linear, P<0.01). The drip loss of breast muscle increased (linear, P<0.01), whereas shear force, pH at 24h postmortem, and breast meat color lightness (L*), redness (a*), and yellowness (b*) scores were not affected. In conclusion, the tested transport durations (from 0.5 to 3h) increased BW loss and some plasma stress biomarkers in 75-day-old Yellow-feathered broiler chickens, but the effect on meat quality attributes was minor.

Ekstraksi Minyak Atsiri Pandan Wangi (Pandanus amaryllifolius Roxb.) dengan Lama Waktu Penyulingan yang Berbeda

The leaves of pandan wangi (Pandanus amaryllifolius Roxb.) are known as food flavor and can be extracted to produce essential oil. Extraction of its essential oil is usually conducted by distillation method that would give added value for this plant. This study aimed to study the effect of different durations of distillation process on the essential oils yield and quality of pandanus using water and steam distillation method. The method used in this research was experimental method with descriptive analysis. This research used five variants duration of distillation, which was repeated two times. The duration of distillation consisted of 2 hours, 4 hours, 6 hours, 8 hours, and 10 hours. The parameters observed to determine the best treatment consisted of the amount of yield produced and the quality parameters including specific gravity, refractive index, acid number, solubility in ethanol 90%, and ester number. Based on the results of the research conducted, distillation to produce the best yield is the duration of 8 hours with a yield value of 0.55%, while distillation to produce the best quality is the duration of 6 hours with a specific gravity of 1.0563 g/mL, refractive index 1.3473, the acid number was 3.274 mg KOH/g, solubility in ethanol 90% (1:1), and ester number of 96.06 mL HCl/g.&#x0D; Keywords: essential oil, pandan wangi, water and steam distillation

Lethal and sub-lethal effects of low-temperature exposures on Halyomorpha halys (Hemiptera: Pentatomidae) adults before and after overwintering

Cold winter temperatures can influence insects’ survival in temperate zones. Brown marmorated stink bug, Halyomorpha halys (Stål) overwinters as adults in natural and human-made structures. In this study, we characterized low temperature mortality rates of H. halys adults that were either entering (ENA) or exiting (EXA) overwintering microhabitats. We considered the effect of different duration of cold exposure on mortality. We determined the impact of insect nutritional status and weight on cold tolerance. We additionally evaluated the effects of cold exposure on H. halys adult longevity and fecundity. Mortality of ENA and EXA adults was determined for 6 h and 2 h periods at − 2.5 °C and 2.5 °C respectively. EXA adults displayed higher mortality rates compared to ENA individuals at the low-temperature regimes. Halyomorpha halys adult survival rate was higher when their nutrient index (EXA individuals only) and weight were high. Low-temperature exposure increased longevity, but reduced fecundity of ENA females. The data further highlight how extreme spring frost events can result in significantly increased mortality levels of H. halys adults.

Effect of different durations of moderate ozone exposure on secondary metabolites of Brassica campestris L. ssp. chinensis

ABSTRACT Tropospheric ozone is an important ambient atmospheric pollutant component in urban areas. Determining plant reactions to ozone in plant growth and biochemical quality contents plays an important role in understanding plant metabolism. This study aimed to provide an understanding of the effect of ozone on early vegetative growth stage Pak-Choi (Brassica campestris L. ssp. chinensis). An experiment was conducted within an airtight bio-chamber for six consecutive days under 60 ppb ozone concentration. Different exposure duration conditions were 0 h/day, 1 h/day, and 4 h/day. The results showed no reaction of plant growth, but ozone exposure led to significant impacts in biochemical quality. The content of photopigments was not significantly impacted at 1 h/day, but significantly increased at the 4 h/day exposure condition. There was a significant decrease in the total glucosinolate (GLS) and total aliphatic GLS after the 4 h/day exposure condition; however, 4-Methylthiobutyl-GLS, total indole, and aromatic GLS were significantly increased. It appears that biochemical systems are more sensitive than the systems controlling plant growth, and this needs to be taken into account when implementing urban production sites for vegetables.

Defining persistent Staphylococcus aureus bacteraemia: secondary analysis of a prospective cohort study

Staphylococcus aureus persistent bacteraemia is only vaguely defined and the effect of different durations of bacteraemia on mortality is not well established. Our primary aim was to analyse mortality according to duration of bacteraemia and to derive a clinically relevant definition for persistent bacteraemia. We did a secondary analysis of a prospective observational cohort study at 17 European centres (nine in the UK, six in Spain, and two in Germany), with recruitment between Jan 1, 2013, and April 30, 2015. Adult patients who were consecutively hospitalised with monomicrobial S aureus bacteraemia were included. Patients were excluded if no follow-up blood culture was taken, if the first follow-up blood-culture was after 7 days, or if active antibiotic therapy was started more than 3 days after first blood culture. The primary outcome was 90-day mortality. Univariable and time-dependent multivariable Cox regression analysis were used to assess predictors of mortality. Duration of bacteraemia was defined as bacteraemic days under active antibiotic therapy counting the first day as day 1. Of 1588 individuals assessed for eligibility, 987 were included (median age 65 years [IQR 51-75]; 625 [63%] male). Death within 90 days occurred in 273 (28%) patients. Patients with more than 1 day of bacteraemia (315 [32%]) had higher Charlson comorbidity index and sequential organ failure assessment scores and a longer interval from first symptom to first blood culture. Crude 90-day mortality increased from 22% (148 of 672) with 1 day of bacteraemia, to 39% (85 of 218) with 2-4 days, 43% (30 of 69) with 5-7 days, and 36% (10 of 28) with more than 7 days of bacteraemia. Metastatic infections developed in 39 (6%) of 672 patients with 1 day of bacteraemia versus 40 (13%) of 315 patients if bacteraemia lasted for at least 2 days. The second day of bacteraemia had the highest HR and earliest cutoff significantly associated with mortality (adjusted hazard ratio 1·93, 95% CI 1·51-2·46; p<0·0001). We suggest redefining the cutoff duration for persistent bacteraemia as 2 days or more despite active antibiotic therapy. Our results favour follow-up blood cultures after 24 h for early identification of all patients with increased risk of death and metastatic infection. None.

Research Note: Delay in sampling influences the profile of phytate in gizzard digesta and ileal digestibility of phosphorus in broilers

The objective of this study was to investigate the effect of different durations of time delay when sampling digesta from the gizzard and ileum of broilers on the degradation of myo-inositol hexakisphosphate (InsP6) and digestibility of phosphorus (P). There was 1 experimental diet with a supplemental phytase activity of 1,212 phytase units/kg feed, which was provided to birds from day 13 to 18 after hatching. The diet was formulated to provide 6.6 g/kg Ca and 1.9 g/kg nonphytate P and fed to 24 cages of 6 birds. The 24 cages of birds were further randomly divided into 6 subgroups of 4 cages from which the digesta samples in the gizzard and ileum were collected at 0, 5, 10, or 20 min postmortem. The results showed that the concentration of InsP6 decreased linearly (P = 0.002), InsP5 decreased quadratically (P = 0.038), and the summation of concentrations of P in InsP6–4 decreased linearly (P = 0.028) in the gizzard digesta with the increasing delay of sampling. In the ileum, the digestibility of phytate P tended to decrease linearly (P = 0.087), and the digestibility of total P decreased linearly (P = 0.026) with prolonged delay. In conclusion, delay in sampling could alter the measured profile of InsP esters in gizzard digesta probably because of a continued effect of supplemental phytase, while the ileal digestibility of total P could diminish. Therefore, standard sampling procedures should be implemented to minimize variance.

Responses of Total Biomass, Shoot Dry Weight, Yield and Yield Components of Jerusalem Artichoke (Helianthus tuberosus L.) Varieties under Different Terminal Drought Duration

As a secondary crop planting in the double-cropping system, terminal drought is the major constraint of Jerusalem artichoke production in the rainfed area. This study aims to estimate the effects of different durations of terminal drought on total biomass, tuber yields, harvest index, yield components, and to identify high yield potential and low yield reduction genotypes for the varietal improvement program. A split-plot design with four replications was conducted under field experiment for two years. Three drought durations including non-drought stress (SD0), drought from 60 and 45 days after transplanting until harvest (SD1 and SD2, respectively), were assigned in main plots and six genotypes were arranged in subplots. Crop parameters were greater decreased under a long-drought duration than under short-drought duration. The genotypes were identified; HEL256, JA37 and JA125 had high yield potential under SD0 conditions, whereas there was high yield reduction under drought conditions. In contrast, JA60 and HEL253 were identified as low yield potential and low yield reduction genotypes. This information suggested that high yield potential genotypes and low yield reduction genotypes should be selected and generated progeny population for improvement of new varieties with high yield potential and low yield reduction for growing in terminal drought-prone environments.

Numerical investigation of lift enhancement in flapping hover flight

The focus of this work is the study of lift enhancement in flapping hover flight using numerical simulations. An idealized set of kinematics for a NACA0012 airfoil consisting of sequential translations and rotations is considered for this purpose, such that the Cl response can be demarcated into translational and rotational parts, which facilitates comparison of forces attributed to translation and rotation. Additionally, comparisons with pure translation and pure rotation are done to isolate the effect of wing–wake interactions. The investigation reveals that the majority of lift is produced in the translational phase. The wing–wake interactions affect the translational phase of the response more than the rotational phase. However, the rotation rate determines the extent of influence of wing–wake interactions on the translational lift response. The effect of different durations of overlap between the translational and rotational motions is also assessed based on the Cl time histories and mean Cl, and the study reveals that an optimum duration of overlap can maximize the lift. An immersed-boundary method with integrated surface-load reconstruction capabilities is used for the computations presented here. The reconstruction of the surface stresses and their integration are carried out with the framework of a parallel solver. The method is validated for a flow past a NACA0012 airfoil executing a non-periodic plunge motion and a non-periodic pitch/plunge motion and a flow around an elliptic airfoil executing a flapping motion.

Correlation between microstructure and micro-hardness of 316L nitrided austenitic stainless steel

This paper presents the effect of duration of solution nitriding towards microstructure and microhardness of AISI 316L stainless steel. The AISI 316L stainless steel was exposed to high temperature gas nitriding process at 1200 °C by using 50% ammonia gas and 50% nitrogen gas for different durations of 8, 15 and 20 hours. The nitrided austenitic stainless steel then underwent several analyses and tests to find the effect of different durations of nitriding towards its microstructures and microhardness. From the experiments conducted to the nitrided samples, it was found that the higher duration of nitriding resulted in the increase of microhardness of the samples due to the increase of nitrogen content in the stainless steel. However, there was no effect found on the microstructure of the nitrided samples. It was noted that the highest hardness was obtained from the nitrided sample of 20 hours that has 245.1 HV which is about 70% higher than the as-received sample.

Quantifying and Mitigating the Impact of the COVID-19 Pandemic on Outcomes in Colorectal Cancer

Background: The COVID-19 pandemic has caused disruption across cancer pathways for diagnosis and treatment. In England, 32% of colorectal cancer (CRC) is diagnosed via urgent symptomatic referral from primary care, the “2-week-wait” (2WW) pathway. Access to routine endoscopy is likely to be a critical bottleneck causing delays in CRC management due to chronic limitation in capacity, acute competition for physician time, and safety concerns. Methods: We used age-specific, stage-specific 10 year CRC survival for England 2007-2017 and 2WW CRC cases volumes. We used per-day hazard ratios of CRC survival generated from observational studies of CRC diagnosis-to-treatment interval to model the effect of different durations of per-patient delay. We utilised data from a large London observational study of faecal immunochemical testing (FIT) in symptomatic patients to model FIT-triage to mitigate delay to colonoscopy. Findings: Modest delays result in significant reduction in survival from CRC with a 4-month delay resulting across age groups in ≥20% reduction in survival in Stage 3 disease and in total over a year, 1,419 attributable deaths across the 11,266 CRC patients diagnosed via the 2WW pathway. FIT triage of >10 ug Hb/g would salvage 1,292/1,419 of the attributable deaths and reduce colonoscopy requirements by >80%. Diagnostic colonoscopy offers net survival in all age groups, providing nosocomial COVID-19 infection rates are kept low (<2·5%). Interpretation: To avoid significant numbers of avoidable deaths from CRC, normal diagnostic and surgical throughput must be maintained. An accrued backlog of cases will present to primary care following release of lockdown, supranormal endoscopy capacity will be required to manage this without undue delays. FIT-triage of symptomatic cases provides a rational approach by which to avoid patient delay and mitigate pressure on capacity in endoscopy. This would also reduce exposure to nosocomial COVID-19 infection, relevant in particular to older patient groups. Funding Statement: MEJ additionally received funding from Breast Cancer Now. B.T and A.G. are supported by Cancer Research UK award C61296/A27223. C.L. and C.T. receive support from the Movember foundation. R.S.H. is supported by Cancer Research UK (C1298/A8362) and Bobby Moore Fund for Cancer. GL is supported by a Cancer Research UK Advanced Clinician Scientist Fellowship Award [C18081/A18180] and is Associate Director of the multi-institutional CanTest Collaborative funded by Cancer Research UK [C8640/A23385]. Research UK). D.C.M is supported by Cancer Research UK (C57955/A24390. A.S. is in receipt of an Academic Clinical Lectureship from National Institute for Health Research (NIHR) and Biomedical Research Centre (BRC) post-doctoral support. This is a summary of independent research supported by the NIHR BRC at the Royal Marsden NHS Foundation Trust and Institute of Cancer Research. Declaration of Interests: The authors declare no competing interests.

The Growth Morphology and Yield of Grey Oyster Mushrooms (Pleurotus sajor-caju) Subjected to Different Durations of Ultrasonic Sound Treatment

Grey oyster mushroom (Pleurotus sajor-caju) is a type of edible mushroom that suitable to be cultivated in Malaysia. There is an increasing demand in the market due to its high nutritional values. In this study, effects of different durations of ultrasonic treatment on the growth morphology, yield enhancement and quality of mushrooms were investigated. Four different durations of ultrasonic treatment had been applied on the mushroom bags which were 1.5, 3.0, 4.5 and 6.0 minutes and 0 minutes act as control. The results showed that all ultrasonic treated bags had shorter time for mycelium to fill-up the mushroom bags as compared to control. Ultrasonic treated bags was observed could promote and activate the pinhead emergence and fruiting bodies formation. Besides, all ultrasonic treated bags also showed higher yield and better quality in terms of the largest pileus diameter of mushrooms as compared to control. For the color of mushrooms, there was no significant different (P>0.05) observed in L* values. However, treatment of 1.5 minutes had the highest a* (redness) and b* (yellowness) values. Different durations of ultrasonic treatment did not showed any significant different in texture and moisture content of mushrooms. In summary, 1.5 minutes was the best treatment duration as it took the shortest time for different growth stages with the greatest yield of mushrooms.

Influence of different photoperiodic conditions on the protein and oil content in soybean seeds (Glycine Max (L.) Merr.)

Aim. Find out the effect of different durations of the photoperiod on the protein and oil content in the seeds of soybean varieties, which differ in response to the photoperiod.Materials and methods. The experiments used photoperiodically neutral soybean varieties Annushka, Yatran, Ustya, as well as a short-day variety Khadzhibey. Plants were grown in the field 2016-2018 year at the experimental site of the Department of Physiology and Biochemistry of Plants and Microorganisms of V.N. Karazin Kharkiv National University on plots of 1 m2 in triplicate. From seedlings to the third true leaf, the plants grew with a natural long day (about 16 hours at the latitude of Kharkov - 50o N). In this phase, half of the plants were exposed to a short photoperiod for 14 days, darkening the plants with light-tight booths from 17 to 9 hours. After which the plants were grown again under long day conditions until the end of the growing season. The second part of the plants (control) during the entire growing season was grown under natural day conditions. The protein content in the seeds was determined on an infrared analyzer Infralum FT-10 (manufacturer Lumex, RF), according to the manufacturer's method, and oil - according to Rushkovsky. Analyzes were performed in two triplicate. The tables show the mean and standard deviations.Results. The protein content in seeds under the influence of a short photoperiod increased, decreased or did not change, compared with the content on a long day, regardless of the type of photoperiodic reaction of the studied varieties. The oil content in the seeds of all varieties, regardless of their photoperiodic reaction, exposed to a short photoperiod, as a rule, was lower than in the seeds of plants that were grown on a long day.Changes in the protein and oil content in the seeds of soybean varieties with different day lengths did not depend on the type of photoperiodic reaction.The content of both protein and oil in seeds varied in different varieties and in different years of research. The degree of variation in different varieties was different.Conclusions. Different photoperiodic conditions ambiguously influenced the protein content in the seeds of soybean varieties with different photoperiodic reactions, although in some years there was a tendency to increase it under the influence of a short photoperiod. Apparently, it is determined by the genotype of the variety and the meteorological conditions of the growing season.The oil content in the seeds of the studied varieties, which differ in the type of photoperiodic reaction, decreased under the influence of a short day, compared with the content under long day conditions.Apparently, the process of accumulation of protein and, especially, oil in soybean seeds is subject to photoperiodic control. Its mechanisms need in-depth studies at the level of physiological and biochemical processes.

The Growth Morphology and Yield of Grey Oyster Mushrooms (Pleurotus sajor-caju) Subjected to Different Durations of Acoustic Sound Treatment

Pleurotus sajor-caju (grey oyster mushroom) is a typical edible fleshy fungi. It has fruiting bodies shape like an oyster that contain high nutrient such as carbohydrates, proteins, fats, minerals and multivitamins. Due to its high nutritional values, the demand of grey oyster mushrooms keeps increasing. In this study, the effect of different durations and intervals of acoustic sound treatment on growth morphology, yield enhancement and the quality of the mushroom were studied. Using sound of fire cracker at constant intensity of 75 dB, four different acoustic sound treatments had been applied on the mushroom bags which were 5 pops at 5-day interval, 15 pops at 5-day interval, 5 pops at 10-day interval and 15 pops at 10-day interval and mushroom bags without any sound treatment acted as control. The results showed that the controls had longer time for mycellium to fill-up the bags compared to sound treated bags. Besides, controls also showed lower yield in terms of number of fruiting bodies and biological efficiencies (%) compared to all acoustic sound treated bags. However, 15 pops at 10-day interval had the shortest time taken to complete all the growth stages (mycellium growth, emergence of pinhead and formation of fruiting bodies). For colour of the mushroom, there were significant differences (P<0.05) in L* values for 15 pops at 5-day interval and no significant different (P>0.05) was observed for a* (redness) and b* (yellowness) values. Controls had the highest firmness value compared to mushroom with sound treatment. In summary, 15 pops at 10-day interval was the best treatment duration and interval as it took the shortest time for different growth stages with the greatest yield of mushrooms.

Different infusion durations for preventing platinum-induced hearing loss in children with cancer.

Platinum-based therapy, including cisplatin, carboplatin or oxaliplatin, or a combination of these, is used to treat a variety of paediatric malignancies. Unfortunately, one of the most important adverse effects is the occurrence of hearing loss or ototoxicity. In an effort to prevent this ototoxicity, different platinum infusion durations have been studied. This review is the third update of a previously published Cochrane Review. To assess the effects of different durations of platinum infusion to prevent hearing loss or tinnitus, or both, in children with cancer. Secondary objectives were to assess possible effects of these infusion durations on: a) anti-tumour efficacy of platinum-based therapy, b) adverse effects other than hearing loss or tinnitus, and c) quality of life. We searched the electronic databases Cochrane Central Register of Controlled Trials (CENTRAL; the Cochrane Library 14 November 2019), MEDLINE (PubMed) (1945 to 14 November 2019) and Embase (Ovid) (1980 to 14 November 2019). In addition, we handsearched reference lists of relevant articles and we assessed the conference proceedings of the International Society for Paediatric Oncology (2009 up to and including 2019) and the American Society of Pediatric Hematology/Oncology (2014 up to and including 2019). We scanned ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform (WHO ICTRP; apps.who.int/trialsearch) for ongoing trials (both searched on 4 November 2019). Randomised controlled trials (RCTs) or controlled clinical trials (CCTs) comparing different platinum infusion durations in children with cancer. Only the platinum infusion duration could differ between the treatment groups. Two review authors independently performed the study selection, 'Risk of bias' assessment and GRADE assessment of included studies, and data extraction including adverse effects. Analyses were performed according to the guidelines of the Cochrane Handbook for Systematic Reviews of Interventions. We identified one RCT and no CCTs; in this update no additional eligible studies were identified. The RCT (total number of children = 91) evaluated the use of a continuous cisplatin infusion (N = 43) versus a one-hour bolus cisplatin infusion (N = 48) in children with neuroblastoma. For the continuous infusion, cisplatin was administered on days one to five of the cycle, but it is unclear if the infusion duration was a total of five days. Risk of bias was present. Only results from shortly after induction therapy were provided. No clear evidence of a difference in hearing loss (defined as asymptomatic and symptomatic disease combined) between the different infusion durations was identified as results were imprecise (risk ratio (RR) 1.39, 95% confidence interval (CI) 0.47 to 4.13, low-quality evidence). Although the numbers of children were not provided, it was stated that tumour response was equivalent in both treatment arms. With regard to adverse effects other than ototoxicity, we were only able to assess toxic deaths. Again, the confidence interval of the estimated effect was too wide to exclude differences between the treatment groups (RR 1.12, 95% CI 0.07 to 17.31, low-quality evidence). No data were available for the other outcomes of interest (i.e. tinnitus, overall survival, event-free survival and quality of life) or for other (combinations of) infusion durations or other platinum analogues. Since only one eligible RCT evaluating the use of a continuous cisplatin infusion versus a one-hour bolus cisplatin infusion was found, and that had methodological limitations, no definitive conclusions can be made. It should be noted that 'no evidence of effect', as identified in this review, is not the same as 'evidence of no effect'. For other (combinations of) infusion durations and other platinum analogues no eligible studies were identified. More high-quality research is needed.

Optimal duration of stretching exercise in patients with chronic myofascial pain syndrome: A randomized controlled trial.

ObjectiveTo explore the effect of variable durations of stretching on neural function, pain, and algometric pressure in patients with chronic myofascial pain syndrome.DesignRandomized controlled trial.PatientsA total of 100 participants diagnosed with chronic myofascial pain syndrome were randomly assigned to a control group or 1 of 3 intervention groups.MethodsThe 3 experimental groups received different durations of cervical spine stretching: 15, 30 or 60 s. The control group did not stretch. Primary outcome measures included peak-to-peak somatosensory-evoked potential for dermatomes C6, C7 and C8. Secondary outcome measures included central somatosensory conduction time (N13–N20), pain intensity, and pressure-pain threshold algometric measurements. All outcome measures were assessed immediately after and 2 h after the treatment session.ResultsPost hoc analysis indicated that stretching for 60 s significantly decreased the dermatomal amplitude for C6, C7 and C8 (p < 0.001) and significantly increased the central conduction time, indicating negative effect (p < 0.001). Stretching for 30 and 60 s resulted in greater improvement in pain intensity and algometric pressure than stretching for 15 s or no stretch (control) p < 0.001.ConclusionStretching cervical muscles involved in chronic myofascial pain syndrome for 30 s was optimal in achieving stretching benefits and minimizing the negative effects on the neural function of the involved nerve roots and central nervous system.LAY ABSTRACTThis study measured the effect of different durations of stretching (15 s, 30 s, 60 s and no stretching) of the muscles around the neck and shoulders in 100 participants with chronic myofascial pain syndrome. The outcome measures assessed the effect on neural function. The results show that stretching for 30 s was the optimal time, for achieving stretching benefits and minimizing the negative effects on the neural function of the involved nerve roots and central nervous system. Stretching for a longer time negatively affected the neural function, but decreased the pain level, while stretching for a shorter time did not achieve the optimal muscle length after stretching.

The content of phenolic acids in the different duration fermented leaves of fireweed (Chamerion angustifolium (L.) Holub)

The purpose of this study was to investigate and determine the effect of different duration of solid-phase fermentation on the change of phenolic acids in fireweed leaves. The leaves of fireweed (Chamerion angustifolium (L.) Holub), naturally growing in a biodynamic farm, were studied in 2017. The aw material was randomly collected from different places of the site in July, at the beginning of mass flowering. In the aboratory of the Institute of Agriculture and Food Sciences Agriculture Academy of Vytautas Magnus University crushed fireweed leaves were fermented under anaerobic conditions at 3°C in a closed dark room for 24 h or 48 h. The experiment was done in three replications. After the fermentation, the raw material was dried at 40°C. The amounts of phenolic acids were measured by high performance liquid chromatography (HPLC). The study data were statistically processed using the analysis of variance (ANOVA). The statistical significance of differences between the means was assessed by Fishers LSD test (p &lt; 0.05). The results of the study indicate that after 24 h duration of solid-phase fermentations the mounts of benzoic and p-coumaric acids increased, but the quantities of gallic, chlorogenic and ellagic acids decreased. After 48 h the opposite results of solid-phase fermentation were observed, that is, the amount of gallic acid increased, while the quantities of chlorogenic, p-coumaric, ellagic and benzoic acids decreased.