Effects Of Deoxycorticosterone Acetate Research Articles

Effects of deoxycorticosterone acetate (DOCA) in ovariectomized, pregnant rats.

Effects of deoxycorticosterone acetate (DOCA) in ovariectomized, pregnant rats.

Plasma renin activity and the effects of deoxycorticosterone acetate in dogs with chronic left ventricular overload.

Chronic left ventricular overload and left heart failure were produced by an aortic-left atrial shunt and superimposed aortic constriction. With the shunt alone, plasma renin activity and sodium balance were normal. Superimposed aortic constriction produced a further elevation in left ventricular end diastolic pressure (LVEDP), increased plasma renin activity and sodium retention occurred. Seven dogs died in pulmonary edema within a week, but nine others recovered with a return in plasma renin activity and sodium excretion to normal. Five of these nine dogs that survived the acute effects of aortic stenosis developed pulmonary edema at least 7 days after aortic constriction; LVEDP was markedly elevated, plasma renin activity was high and sodium retention occurred. Six other dogs with chronic left ventricular overload, but not retaining sodium, were given deoxycorticosterone acetate (DOCA), 15 mg/day, to study the response in renal sodium excretion. In two of the dogs, LVEDP was below 35 mm Hg and the normal "escape" pattern, characterized by return of sodium excretion to the normal control level, was observed. However, in the other four animals, LVEDP was above 35 mm Hg, escape failed to occur and marked sodium retention resulted; a further elevation of LVEDP was observed and pulmonary edema occurred on four occasions. The failure of dogs with marked elevation of LVEDP to escape from DOCA indicates that other factors in addition to the renin-angiotensin-aldosterone system are involved in the sodium retention of left ventricular failure.

Sodium and potassium exchanges in adrenalectomized rats administered deoxycorticosterone chronically.

Fifteen male adrenalectomized rats were divided into three equal groups and given powdered Purina diet and a choice between 0.30 M NaCl solution and distilled water. Body weight, intakes of food and fluids, urine output, and urine sodium and potassium concentrations were measured daily during a 7-day control period. At this time, two of the groups were administered 250 and 500 μg deoxycorticosterone acetate (DOCA) per kg body weight per day s.c. in oil. Controls received oil. The measurements listed above were taken for an additional 11 days of treatment. All groups ingested more NaCl solution than water during the control period. When DOCA was begun, both sodium output (meq/day) and intake (meq/day) were reduced proportionately and the linear relationship between them observed before treatment was maintained. Under these conditions adrenalectomized rats failed to escape from the sodium-retaining effects of DOCA. Furthermore, both the reduced output and intake of sodium remained for 10 days after drug administration ceased. Although administration of DOCA increased potassium excretion, food intake also increased such that the relationship between potassium intake and output observed before treatment was maintained. The urinary Na/K ratio was reduced significantly during drug treatment. The results suggest that mineralo-corticoid hormones are important in the control of both output and intake of sodium in the rat.

Chronic experimental left heart failure in the dog.

ARTICLESChronic experimental left heart failure in the dogJS Baumber, JO Davis, JW Mackenzie, EG Schneider, JA Johnson, and CA RobbJS Baumber, JO Davis, JW Mackenzie, EG Schneider, JA Johnson, and CA RobbPublished Online:01 Aug 1970https://doi.org/10.1152/ajplegacy.1970.219.2.474MoreSectionsPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByThe renin-angiotensin-aldosterone system in rabbits with congestive heart failure produced by aortic constriction.Circulation Research, Vol. 40, No. 3Factors influencing the development of pulmonary edema in dogs with left ventricular overloadPlasma Renin Activity and the Effects of Deoxycorticosterone Acetate in Dogs with Chronic Left Ventricular OverloadCirculation Research, Vol. 27, No. 5 More from this issue > Volume 219Issue 2August 1970Pages 474-480 Copyright & PermissionsCopyright © 1970 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1970.219.2.474PubMed5448080History Published online 1 August 1970 Published in print 1 August 1970 Metrics

Response of the chronic cardiac denervated dog to acute volume expansion.

ARTICLESResponse of the chronic cardiac denervated dog to acute volume expansionJP Gilmore, and WM DaggettJP Gilmore, and WM DaggettPublished Online:01 Mar 1966https://doi.org/10.1152/ajplegacy.1966.210.3.509MoreSectionsPDF (729 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByPost-transplant Complications: Hypertension, Renal Dysfunction, Diabetes Mellitus, Malignancy, Arrhythmias, Osteoporosis, Sexual Dysfunction22 February 2017Sodium Balance in Heart Failure28 February 2013High dose angiotensin-converting enzyme inhibition prevents fluid volume expansion in heart transplant recipientsJournal of the American College of Cardiology, Vol. 36, No. 2The kidney in cardiac failure: today’s perspectiveMechanisms of Tubular Sodium Chloride Transport7 July 2009 | Renal Failure, Vol. 20, No. 6Function of the Transplanted Heart: Unique Physiology and Therapeutic ImplicationsThe American Journal of the Medical Sciences, Vol. 314, No. 3Breakdown of blood pressure and body fluid homeostasis in heart transplant recipientsJournal of the American College of Cardiology, Vol. 27, No. 2Renal Salt and Water Handling in Congestive Heart FailureTask force 4: Function of the heart trnsplant recipientJournal of the American College of Cardiology, Vol. 22, No. 1Neural Control of Renal Function1 January 2011Atrial natriuretic hormones — Thirty years after the discovery of atrial volume receptorsKlinische Wochenschrift, Vol. 64, No. 16Southwestern Internal Medicine Conference: Renal Sodium Excretion and Atrial Natriuretic FactorThe American Journal of the Medical Sciences, Vol. 291, No. 3Cellular mechanism of release of atrial natriuretic factorBiochemical and Biophysical Research Communications, Vol. 124, No. 2Pathogenesis of Sodium and Water Retention in Edematous DisordersAmerican Journal of Kidney Diseases, Vol. 2, No. 2Factors influencing renal sodium reabsorption in volume expansion20 June 2005The role of the cardiac nerves in the regulation of sodium excretion in conscious dogsPfl�gers Archiv European Journal of Physiology, Vol. 390, No. 2Escape from the sodium-retaining effects of mineralocorticoidsKidney International, Vol. 17, No. 3Natriuretic hormone--its possible role in fluid and electrolyte disturbances in chronic liver diseasePostgraduate Medical Journal, Vol. 51, No. 598The contribution of atrial stretch receptors to salt and water homeostasis in the humanBasic Research in Cardiology, Vol. 70, No. 4Effects of adrenergic nervous system and catecholamines on systemic and renal hemodynamics, sodium and water excretion and renin secretionKidney International, Vol. 6, No. 5Intrathoracic Volume ReceptorsNew England Journal of Medicine, Vol. 286, No. 10Tubular Reabsorption of Sodium Ion: Influence of Factors Other Than Aldosterone and Glomerular Filtration RateNew England Journal of Medicine, Vol. 285, No. 23Plasma Renin Activity and the Effects of Deoxycorticosterone Acetate in Dogs with Chronic Left Ventricular OverloadCirculation Research, Vol. 27, No. 5Comparison of polarizing solution and isovolumic KCl in digitalis-induced ventricular tachycardiaAmerican Heart Journal, Vol. 80, No. 1Physiology and Pharmacology of the Transplanted HeartEffects of glucose and nonglucose infusions on myocardial potassium ion transfers and arrhythmias during ischemiaThe American Journal of Cardiology, Vol. 24, No. 5Sodium MetabolismNew England Journal of Medicine, Vol. 281, No. 2 More from this issue > Volume 210Issue 3March 1966Pages 509-512 Copyright & PermissionsCopyright © 1966 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1966.210.3.509PubMed5933201History Published online 1 March 1966 Published in print 1 March 1966 Metrics

Effects of deoxycorticosterone acetate in unilaterally nephrectomized dogs with renal artery constriction.

The response to the chronic daily administration of 25 mg/day of deoxycorticosterone acetate (DCA) was studied before and following renal artery constriction in unilaterally nephrectomized dogs. Both before and after constriction of the renal artery there was an initial period of Na retention which lasted 1–5 days but all animals escaped from the Na-retaining action of DC A. Glomerular filtration rate (GFR) and renal plasma flow (RPF) as measured in the postabsorptive state were reduced in 7 of the 8 dogs with renal artery constriction, and a subsequent rise in renal function was not detected during DCA injection. Also, the normal postprandial rise in GFR failed to occur during DCA administration to dogs with renal artery constriction. Fractional urine collections revealed a normal pattern of renal Na excretion during DCA administration to dogs with renal artery stenosis in that most of the Na ingested with the meal was excreted during the postprandial period. The present data demonstrate, therefore, that...

Influence of adrenal cortex on body water distribution in rats

Body water distribution was determined in rats by the dilution of serum albumin-I131 and Br82 and by desiccation. Methylprednisolone (MP) increased the plasma and intracellular compartments and decreased the interstitial volume in intact hydrated rats. The body water moved in the opposite direction in the adrenalectomized, salt-maintained rats, and MP prevented this movement in terms of intracellular and interstitial volumes. Adrenalectomized rats which were salt depleted had an increased intracellular volume with water coming from both extracellular compartments, and MP had no effect in this group. The effect of deoxycorticosterone acetate was to increase plasma volume in the intact hydrated and in both adrenalectomized groups. The relationship between these changes in body water distribution, hematocrit, and plasma osmolality and sodium concentrations has been discussed.

Sodium excretion in adrenalectomized dogs with chronic cardiac failure produced by pulmonary artery constriction.

ArticleSodium Excretion in Adrenalectomized Dogs With Chronic Cardiac Failure Produced by Pulmonary Artery ConstrictionJames O. Davis, David S. Howell, and Robert E. HyattJames O. DavisFrom the Laboratory of Kidney and Electrolyte Metabolism, National Heart Institute, National Institutes of Health, Bethesda, Maryland, David S. HowellFrom the Laboratory of Kidney and Electrolyte Metabolism, National Heart Institute, National Institutes of Health, Bethesda, Maryland, and Robert E. HyattFrom the Laboratory of Kidney and Electrolyte Metabolism, National Heart Institute, National Institutes of Health, Bethesda, MarylandPublished Online:31 Oct 1955https://doi.org/10.1152/ajplegacy.1955.183.2.263MoreSectionsPDF (892 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByAn extra-adrenal sodium-retaining factor in congestive heart failureJournal of Cardiac Failure, Vol. 1, No. 2Die Pathogenese des kardialen ÖdemsEscape from the sodium-retaining effects of mineralocorticoidsKidney International, Vol. 17, No. 3Effects of the oral converting enzyme inhibitor, SQ 14225, in a model of low cardiac output in dogs.Circulation Research, Vol. 45, No. 4The role of renin and aldosterone in the salt retention of edemaThe American Journal of Medicine, Vol. 63, No. 6Renal consequences of valvular heart diseaseThe American Journal of Cardiology, Vol. 35, No. 6Biochemical aspects of congestive heart failure in children: Part IIThe Journal of Pediatrics, Vol. 84, No. 5Mechanism of sodium and water retention in rats with experimental heart failureKidney International, Vol. 4, No. 5Interrelationship of hemodynamic alterations of valvular heart disease and renal function: Influences on renal sodium reabsorptionAmerican Heart Journal, Vol. 84, No. 2Natriumresorption in oberflächlichen Nephronen und intrarenale Filtratverteilung bei herzinsuffizienten RattenPlasma Renin Activity and the Effects of Deoxycorticosterone Acetate in Dogs with Chronic Left Ventricular OverloadCirculation Research, Vol. 27, No. 5Niere und HerzinsuffizienzThe Role of the Adrenal Cortex in the Pathogenesis of a Spontaneous, Hereditary Congestive Heart FailureAn Extra-Adrenal Factor Essential for Chronic Renal Sodium Retention in Presence of Increased Sodium-Retaining HormoneCirculation Research, Vol. 14, No. 1Heart Failure in Infants and Children18 April 2016 | Postgraduate Medicine, Vol. 34, No. 3Salt and water excretion in heart failureProgress in Cardiovascular Diseases, Vol. 3, No. 6Renal function and renal impairment in congestive heart failureProgress in Cardiovascular Diseases, Vol. 3, No. 5Mechanisms of salt and water retention in congestive heart failureThe American Journal of Medicine, Vol. 29, No. 3Pathophysiologie der HerzinsuffizienzThe Kidney in Congestive Heart FailureCirculation, Vol. 21, No. 1Sodium and water retention in chronic congestive heart failureJournal of Chronic Diseases, Vol. 9, No. 5The alkali metal ions in the organismRe-examination of salt and water retention in congestive heart failureThe American Journal of Medicine, Vol. 25, No. 4 More from this issue > Volume 183Issue 2October 1955Pages 263-268 Copyright & PermissionsCopyright © 1955 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1955.183.2.263PubMed13268674History Received 11 April 1955 Published online 31 October 1955 Published in print 31 October 1955 Metrics

Simultaneous Administration of Adrenal Cortical Extract and Desoxycorticosterone; Effects on Blood Pressure of Hypertensive Patients.

ConclusionsIn patients with hypertensive vascular disease, the simultaneous administration of an adrenal cortical extract appears to block the pressor effect of deoxycorticosterone acetate when used alone.