Effect Of Cortisone Acetate Research Articles

Cortisone and gold therapy in chronic rheumatoid arthritis.

Article1 April 1952CORTISONE AND GOLD THERAPY IN CHRONIC RHEUMATOID ARTHRITISHARRY E. THOMPSON, M.D., F.A.C.P., HAROLD J. ROWE, M.D.HARRY E. THOMPSON, M.D., F.A.C.P.Search for more papers by this author, HAROLD J. ROWE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-4-992 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis study of cortisone and gold therapy in rheumatoid arthritis appeared to be of interest since cortisone, despite its remarkable effect in this disease,1has not proved of expected value. It was hoped that this steroid would permanently and completely inactivate rheumatoid arthritis. However, there is evidence2, 3, 4that in most instances cortisone acts only as a suppressive agent, and it is known that undesirable physiologic actions may result from its prolonged administration.5Hence, it appeared worth while to determine if cortisone and gold given concurrently, or if cortisone given to patients already receiving gold, would increase the effect...Bibliography1. HenchKendallSlocumbPolley PSECCHHF: Effects of cortisone acetate and pituitary ACTH on rheumatoid arthritis, rheumatic fever and certain other conditions: a study in clinical physiology, Arch. Int. Med. 85: 545-666 (April) 1950. CrossrefGoogle Scholar2. IronsAyerBrownArmstrong ENJPRGHS: ACTH and cortisone in diffuse collagen disease and chronic dermatosis, J. A. M. A. 145: 861-869, 1951. CrossrefMedlineGoogle Scholar3. Editorial: Effects of cortisone and pituitary adrenal corticotropic hormone, J. A. M. A. 142: 730-731 (March 11), 1950. CrossrefGoogle Scholar4. SofferLevittBaehr LJMFG: Use of cortisone and adreno-corticotropic hormone in acute disseminated lupus erythematosus, Arch. Int. Med. 86: 558-573 (Oct.) 1950. CrossrefGoogle Scholar5. Sprague RC: Observations on the physiologic effects of cortisone and ACTH in man, Arch. Int. Med. 85: 199-258 (Feb.) 1950. CrossrefGoogle Scholar6. ThompsonWyattHicks HEBLRA: Chronic atrophic arthritis, Ann. Int. Med. 11: 1792-1805 (April) 1938. LinkGoogle Scholar7. SteinbrockerTraegerBatterman OCHRC: Therapeutic criteria in rheumatoid arthritis, J. A. M. A. 140: 659-662 (June 25) 1949. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Tucson, Arizona*Received for publication August 29, 1951.Presented in part before the Arizona Rheumatism Association, May, 1951, Tucson, Arizona.Aided by grants from the B. Montgomery and A. Vela Clinical Research Fund. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCombined Therapy of Rheumatoid Arthritis with Gold and Chloroquine: II Evaluation of the Side EffectsCombined Therapy of Rheumatoid Arthritis with Gold and Chloroquine: II Evaluation of the Side EffectsMorbus ReiterErkrankungen des EndokardRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (ELEVENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., WILLIAM S. CLARK, M.D., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P. (C), MAX M. MONTGOMERY, M.D., F.A.C.P., BERNARD M. NORCROSS, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D., F.A.C.P.Arthritis ResearchGOLD-HORMONAL THERAPY IN RHEUMATOID ARTHRITIS*PAUL J. BILKA, M.D., MAX H. WEIL, M.D.Rheumatoid arthritis: A review of recent advances in our knowledge concerning pathology, diagnosis, and treatment 1 April 1952Volume 36, Issue 4Page: 992-1000KeywordsResearch fundingRheumatoid arthritis ePublished: 1 December 2008 Issue Published: 1 April 1952 PDF downloadLoading ...

The effect of cortone and ACTH on the histopathologic lesions of rheumatoid arthritis.

Article1 March 1952THE EFFECT OF CORTONE AND ACTH ON THE HISTOPATHOLOGIC LESIONS OF RHEUMATOID ARTHRITISBERNARD M. NORCROSS, M.D., F.A.C.P., L. MAXWELL LOCKIE, M.D., F.A.C.P., ANTHONY G. CONSTANTINE, M.D., JOHN H. TALBOTT, M.D., F.A.C.P., ROBERT H. STEIN, M.D.BERNARD M. NORCROSS, M.D., F.A.C.P.Search for more papers by this author, L. MAXWELL LOCKIE, M.D., F.A.C.P.Search for more papers by this author, ANTHONY G. CONSTANTINE, M.D.Search for more papers by this author, JOHN H. TALBOTT, M.D., F.A.C.P.Search for more papers by this author, ROBERT H. STEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-3-751 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis investigation was intended to demonstrate any effect of Cortone and ACTH upon the histopathologic lesions of rheumatoid arthritis. In 1945, Freund, Steiner and their associates1, 2described an inflammatory lesion of striated muscle in patients with rheumatoid arthritis. This lesion, consisting of a localized collection of lymphocytes, was widely distributed in the skeletal muscles, and was called "nodular polymyositis." The authors believed these lesions to be specific for rheumatoid arthritis, but other observers3-8have demonstrated the presence of similar changes in a variety of disease states and even in normal individuals. Two reports deserve special attention in this respect....Bibliography1. FreundSteinerLeichtentrittPrice HAGBAE: Nodular polymyositis in rheumatoid arthritis, Science 101: 202, 1945. CrossrefMedlineGoogle Scholar2. SteinerFreundLeichtentrittMaun GHABME: Lesions of skeletal muscles in rheumatoid arthritis; nodular polymyositis, Am. J. Path. 22: 103, 1946. Google Scholar3. Black-Schaffer B: Discussion of Steiner et al., Am. J. Path. 22: 647, 1946. Google Scholar4. ClawsonNobleLufkin BJJFNH: Nodular inflammatory and degenerative lesions of muscles from four hundred and fifty autopsies, Arch. Path. 43: 579, 1947. Google Scholar5. DeForestBuntingKenney GKHWE: Rheumatoid arthritis; diagnostic significance of focal cellular accumulations in skeletal muscles, Am. J. Med. 2: 40, 1947. CrossrefMedlineGoogle Scholar6. BunimSokoloffWilensMcEwen JJLSLC: Cellular aggregates in skeletal muscle of patients with rheumatic diseases other than rheumatoid arthritis, Abst., Ann. Rheum. Dis. 7: 251, 1948. MedlineGoogle Scholar7. SokoloffWilensBunimMcEwen LSLJJC: Diagnostic value of histologic lesions of striated muscle in rheumatoid arthritis, Am. J. M. Sc. 219: 174, 1950. CrossrefMedlineGoogle Scholar8. Ogryzlo MA: Chronic inflammatory lesions of skeletal muscle in rheumatoid arthritis and in other diseases, Arch. Path. 46: 301, 1948. Google Scholar9. RaganGrokoestBoots CAWRH: Effect of adrenocorticotrophic hormone (ACTH) on rheumatoid arthritis, Am. J. Med. 7: 741, 1949. CrossrefMedlineGoogle Scholar10. HenchKendallSlocumbPolley PSECCHHF: Effects of cortisone acetate and pituitary ACTH on rheumatoid arthritis, rheumatic fever, and certain other conditions, Arch. Int. Med. 85: 545, 1950. CrossrefGoogle Scholar11. BauerGiansiracusaRopes WJEMW: The natural course of rheumatoid arthritis and the changes induced by ACTH, Tr. A. Am. Physicians 63: 76, 1950. MedlineGoogle Scholar12. RaganHowesPlotzMeyerBlunt CELCMKJW: Effect of cortisone on production of granulation tissue in rabbit, Proc. Soc. Exper. Biol. and Med. 72: 718, 1949. CrossrefMedlineGoogle Scholar13. CreditorBevansMundyRagan MCMWLC: Effect of ACTH on wound healing in humans, Proc. Soc. Exper. Biol. and Med. 74: 245, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 1, 1951.From the University of Buffalo School of Medicine and the Buffalo General Hospital, Buffalo, New York.This study was aided by a grant from the Weed Foundation, Buffalo, New York.Portions of this paper were given at the annual meeting of the American Rheumatism Association, June 23, 1950, San Francisco, and also at the Western New York Regional Meeting of the American College of Physicians, October 14, 1950, Rochester, New York. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKurative ACTH-Wirkung bei chronischer Fremdserumkarditis des KaninchensDie Herz- und GefäßkrankheitenRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (ELEVENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., WILLIAM S. CLARK, M.D., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P. (C), MAX M. MONTGOMERY, M.D., F.A.C.P., BERNARD M. NORCROSS, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D., F.A.C.P.Pulmonary lesions in “rheumatoid disease” with remarks on diffuse interstitial pulmonary fibrosisRheumatoid arthritis: A review of recent advances in our knowledge concerning pathology, diagnosis, and treatmentAetiology and pathogenesis of rheumatoid arthritisPhysiology of the Adrenal CortexINTERRUPTION BY TOPICAL CORTISONE OF LEUKOCYTIC CYCLES IN ACUTE INFLAMMATION IN MANFocal Infection in Relation to Health and Disease 1 March 1952Volume 36, Issue 3Page: 751-764KeywordsAdrenocorticotropic hormoneHospital medicineLesionsLymphocytesMusclesPolymyositisRheumatoid arthritisSkeletal muscles ePublished: 1 December 2008 Issue Published: 1 March 1952 Copyright & PermissionsCopyright, 1952, by The American College of PhysiciansPDF downloadLoading ...

Effect of cortisone acetate on an experimental purulent infectious arthritis of white mice.

the human throat capable of producing joint lesions in laboratory animals, three strains of alpha type Streptococcus have been isolated which cause an experimental infection in albino rats and mice characterized by a high incidence of polyarthritis and lesions in the heart and kidneys (Friedlander, 1951). The response in mice to intravenous inoculation of various doses of these organisms has been found to be highly uniform. The incidence of arthritis and

Effect of cortisone acetate upon plasma amino acids in the eviscerate rat.

SummaryMale rats were eviscerated and eviscerated-adrenalectomized. All of the animals received continuous intravenous infusions of saline with glucose and insulin for 24 and 48 hours. The administration of cortisone acetate in doses of 5 and 10 mg per 24 hours to one rat of each pair caused significant increases in the concentration of plasma amino acids above the values for untreated animals. It is postulated that the observed change represents an extra-hepatic effect of cortisone upon protein metabolism.