This study aimed to investigate a method and effects of community participation in an Islamic drug prevention method among Thai Muslim youths in Ban Don Khilek, Tambon Phawong, Muang District, Songkhla Province. The data were collected through in-depth interviews, group discussions, and practice with four groups of key informants, namely, 20 Muslim youths, 10 parents and guardians, 8 religious leaders, and 3 local leaders. Descriptive content analysis was conducted using comparative logic of concepts, theories, research reports, and context.The findings revealed that a suitable Islamic way of drug prevention method was the establishment of a group called “Creative Youth Group of Ban Don Khilek” with religious leaders, and local leaders as consultants and supporters. The main role of the youth group was organizing creative activities for learning which were learning activities on Islam and the way of living, group discussions, moral and ethical camp for youths, training for parents and guardians, and information broadcasting activities. The study was financially supported by the Institute of Southern Health Research and Development, Prince of Songkla University. The activities emphasized on participation from all parties and continuity of the activities. It was found that the process of organizing activities could develop youths’ potential in various aspects. Moreover, the target group acquired knowledge, learned facts about harms of drug addiction, and practiced living according to the Islamic way that eventually led them far away from drugs.