Chemical reaction induced particle collision and aggregations in gas-solid phase reaction were presented in this work. The characteristics of particle collision and aggregations in non-catalytic gas-solid phase reaction- petcoke particles combustion process in air was experimentally analyzed. The reason for the formation of different aggregation structures is the reactant concentration distribution and particle position. Different spatial positions of solid particles caused the non-uniform concentration distribution of gaseous reactant and product around particle surface. The non-uniform distribution of gaseous reactant results in cohesive force, which lead to particle collision and aggregations. The aggregates of multi-particles tend to show “I” and “L” structure with the effect of cohesive force and drag force. Simulation work also were conducted to analyze the reactant and product concentrations, release velocity of product and bearing force of solid particles. The mechanisms of different particle aggregation patterns were demonstrated.