The current study evaluated the effect of feeding clove (Syzygium aromaticum) as a natural additive on productive performance, digestibility and nutritive value, antioxidant enzymes activities, and immune response of growing rabbits. A total of 48 New Zealand White (NZW) rabbits aged 6 weeks were randomly allocated to 4 groups (12 rabbits/group). Clove buds powder (CLP) was supplemented at 0.5, 1, and 1.5% of basal diet. Four tested diets formulated to contain basal diet without CLP (treatment 1, T1), 0.5% CLP (T2), 1% CLP (T3), and 1.5% CLP (T4). The animals were provided pelleted diets and fresh water ad libitum throughout the experimental period. The rabbits fed diets containing CLP improved FCR (P=0.007) and consumed (P<0.0001) less than those fed control group. The diet containing 1.5% CLP had the best feed conversion ratio (FCR) value (P<0.05). No significant differences were observed among experimental groups in all nutrients digestibility except CP digestibility significantly (P=0.0261) increased with 0.5 and 1% CLP groups compared to control group. Blood total lipid (TL) was significantly decreased (P<0.009) with increasing the dietary level of CLP, (being 379.17 and 361.11 mg/dl for 1% and 1.5% CLP groups vs. 470.84 for control group). The catalase and total antioxidant capacity (TAOC) concentrations significantly (P<0.0001) increased with CLP groups compared to control group. The immunoglobulins titres (IgG and IgM) improved (P>0.05) with rabbits fed CLP diets when compared to those fed the control diet. In conclusion, using CLP as an alternative feed additive in rabbit’s diets up to 1.5% without any adverse effect on productive performance and vital activities. The CLP inclusion in rabbit diets decreased feed intake (FI), improved FCR and increased profitability, moreover, had a positive effect on antioxidant enzyme activity and immunity (IgG and IgM) titres.