Event Abstract Back to Event Effects of dopamine agonist bromocriptine on alcohol induced stress ulcer lesions in rats Julijana Rasic1*, Snezana Janicijevic-Hudomal1, Vesna Piperski2, Mira Popovic3 and Radoslav Mittic1 1 University of Pristina, Institute of Pharmacology and Toxicology, Kosovo 2 Galenika A.D., Department of biomedical research, Serbia 3 University of Novi Sad, Department of Chemistry, Serbia Introduction. Stress ulcers represent acute lesions of gastric mucosa resulting from influence of various factors: burn, surgical operation, trauma, shock, severe metabolic disorders, drug administration, etc. Alcohol causes stress gastric ulcerations and hemorrhage. Bromocriptine, a dopamine D2 receptor agonist and mild D1 receptor antagonist, has been shown to be an effective protective factor against stress ulcerogenesis. The aim of this study was to investigate the effects of bromocriptine given before alcohol induced stress, on the development of stress ulcer lesions. Methods. Research was performed on adult, male, white laboratory rats type Wistar weighting 200-230 grams and aged up to 3 months. All animals were put on starving in standard metabolic cages, 24h before the experiment. Alcohol stress was induced, in each animal, by intragastric administration of 1 ml of absolute alcohol (96%). Bromocriptine® (2.5 mg tablets, Zdravlje, Leskovac, Serbia), was dissolved in distilled water immediatey prior to administration. It was administered by intragastric application 24 h n.g. prior to stress 25 mg/kg bw and 30 minutes prior to stress 12.5 mg/kg bw. Results. Alcohol induced stress led to changes in the stomach indicated by profuse submucosal hemorrhage. Changes observed as erosions and petechiae, were confirmed pathohistologically as defects in mucosa and submucosal hemorrhage. Bromocriptine administrated before alcohol induced stress, reduced ulcer index (UI) from 128.94±71.30 mm2 to 72.54±42.53 mm2, which is statistically significant (p<0.05). Conclusions. Bromocriptine administrated in pretreatment period of alcohol induced stress significantly decreased dimensions of stress ulcer lesions in rats. Keywords: Dopamine Agonists, Bromocriptine, alcohol Conference: 8th Southeast European Congress on Xenobiotic Metabolism and Toxicity - XEMET 2010, Thessaloniki, Greece, 1 Oct - 5 Oct, 2010. Presentation Type: Poster Topic: Xenobiotic toxicity Citation: Rasic J, Janicijevic-Hudomal S, Piperski V, Popovic M and Mittic R (2010). Effects of dopamine agonist bromocriptine on alcohol induced stress ulcer lesions in rats. Front. Pharmacol. Conference Abstract: 8th Southeast European Congress on Xenobiotic Metabolism and Toxicity - XEMET 2010. doi: 10.3389/conf.fphar.2010.60.00187 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 28 Oct 2010; Published Online: 04 Nov 2010. * Correspondence: Dr. Julijana Rasic, University of Pristina, Institute of Pharmacology and Toxicology, Kosovska Mitrovica, Kosovo, sr_juca@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Julijana Rasic Snezana Janicijevic-Hudomal Vesna Piperski Mira Popovic Radoslav Mittic Google Julijana Rasic Snezana Janicijevic-Hudomal Vesna Piperski Mira Popovic Radoslav Mittic Google Scholar Julijana Rasic Snezana Janicijevic-Hudomal Vesna Piperski Mira Popovic Radoslav Mittic PubMed Julijana Rasic Snezana Janicijevic-Hudomal Vesna Piperski Mira Popovic Radoslav Mittic Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.