Effects Of Black Cumin Research Articles

The Effect of Black Cumin (Nigella sativa) on Hb and VEGF Levels in Lung Cancer Patients Undergoing Chemotherapy at Dr. Saiful Anwar General Hospital, East Java

The Effect of Black Cumin (Nigella sativa) on Hb and VEGF Levels in Lung Cancer Patients Undergoing Chemotherapy at Dr. Saiful Anwar General Hospital, East Java

THE EFFECT OF BLACK CUMIN (NIGELLA SATIVA L.) ON THE IMMUNE SYSTEM FOR ORAL HEALTH

The immune system is a system that is able to protect the body from microorganisms that cause disease. This system can limit microbial colonization in the oral cavity and prevent the penetration of harmful substances. The immune system is related to health problems in the oral cavity. Black cumin (Nigella sativa L.) has the main active component, namely thymoquinone. Thymoquinone has an immunomodulatory, anti-inflammatory, analgesic, and antioxidant effect that shows an important role in oral disease management and also in oral health. Research shows that the substance thymoquinone in black cumin has an effect on increasing the immune system in the oral cavity. The research analyzed was research on the effect of black cumin on the immune system for oral health. The use of black cumin containing thymoquinone is effective for increasing the immune system in the oral cavity, if used at a concentration of 0.1%-0.2% and applied directly to the area that is experiencing inflammation. So it can be concluded that black cumin has an effect on increasing the immune system in the oral cavity.

Effect of Black Cumin (Nigella sativa) on Prostate Health: Narrative Review

A growing amount of research is shedding light on functional foods and nutritional supplements’ potential health and disease-preventative advantages. Black cumin (Nigella sativa L.), an esteemed nutraceutical herb, is well-known for its multiple health advantages among health-conscious individuals, researchers, and pharmaceutical businesses. Black cumin and its principal bioactive ingredient, thymoquinone (TQ), have been found to lower oxidative stress and inflammation, while also enhancing immunological function, cellular viability, and energy metabolism. They protect against metabolic, cardiovascular, digestive, hepatic, renal, pulmonary, reproductive, and neurological diseases, as well as cancer. Black cumin works as a countermeasure to minimize the toxicity and side effects of pharmaceuticals. Furthermore, the possible effects of black cumin on prostate health and disorders like benign prostatic hyperplasia and prostate cancer are not well understood. This narrative review seeks to reveal knowledge gaps. This study intends to guide future research into the possible uses of black cumin and TQ in prostate health and illness.

Effect of black cumin (Nigella sativa) seeds extract in tris egg yolk citrate extender on sperm motility of cryopreserved Surti buck semen

Effect of black cumin (Nigella sativa) seeds extract in tris egg yolk citrate extender on sperm motility of cryopreserved Surti buck semen

Effect of black cumin (Nigella sativa) seeds extract in tris egg yolk citrate extender on viability of cryopreserved Surti buck semen

Effect of black cumin (Nigella sativa) seeds extract in tris egg yolk citrate extender on viability of cryopreserved Surti buck semen

Effects of black cumin, fenugreek, and sesame seeds as a mixture on performance, intestinal morphology, and blood traits of broilers under chronic heat stress conditions

This study aimed to investigate the impact of a seed mixture (SM) (black cumin, fenugreek, and sesame) on broiler chickens’ performance, intestinal morphology, and blood traits under chronic heat stress conditions. 330-day-old male Ross 308 chicks were divided into five treatments (6 replicates and 11 birds per each) consisting of a corn-soybean supplemented with 0, 1.5, 3, 4.5, and 6% SM for 45 days in a completely randomised design. 6% SM supplementation increased body weight (BW) at 45 days of age, average weight gain (AWG) at 26-45 days, and total rearing period under heat stress conditions (p < 0.05). Adding 3% SM to broiler diets increased average feed intake (AFI) at 26-45 and 1-45 days, feed conversion ratio (FCR) at 12-25, and the mortality rate decreased from 28.8% (0% SM) to 12.1% (6% SM) (p < 0.05). Adding SM had no significant effects on the relative weight of carcase segments and internal organs (p > 0.05) except for the duodenum, which increased weight and length at the level of 6% (p < 0.05). The red blood cell (RBC) count and haemoglobin were elevated in chicks inoculated with 3% and 6% SM, respectively (p < 0.05). The mean corpuscular volume (MCV) value increased following the supplementation of SM, while differential white blood cell (WBC) counts did not influence. Aspartate aminotransferase (AST) and Alanine transaminase (ALT) activity declined in chicks that received 6% SM at 45 days of age (p < 0.05). SM supplementation decreased liver steatosis, uric acid, glucose, total protein, and lipid profile concentrations of serum (p < 0.05). Therefore, we conclude that adding SM to the broiler diets at 6% level significantly improves broiler performance, blood traits, and liver health under chronic heat-stress conditions.

The effects of black cumin (Nigella sativa l..) seed on carcass characteristics, kidney oxidant antioxidant levels and ileum histomorphology in Japanese quails

This study aims to determine the effects of supplementation of different doses of black cumin seeds (NS) to quail feeds on carcass characteristics, kidney oxidant antioxidant levels, and ileum histomorphology. A total of 432 mixed-sex three days old Japanese quails were randomly divided into four groups. The groups were fed on either a basal diet alone (Control Group) or a basal diet supplemented with NS at rates of 0.5% (NS-0.5 Group), 1% (NS-1 Group), and 2% (NS-2 Group). It was determined that the back+neck weight in the NS-2 group and head weight and ratio in the NS-1 and NS-2 groups decreased. The thigh rate increased in the NS-0.5 group compared to the control and other NS groups. Kidney glutathione, glutathione peroxidase, and male quails' catalase values were increased in NS groups compared to the control group. The kidney vitamin C increased only in the NS-2 group compared to the control. In the NS-2 group, the villus height decreased both on a group basis and in female quails, while the villus width decreased only in female quails. Consequently, it was determined that dietary supplementation of NS at rates of 0.5% increased the thigh rate, dietary supplementation at three different doses of NS were effective in maintaining the kidney oxidant-antioxidant balance, and the ileum histomorphology did not change except for dietary supplementation of NS at rates of 2%. Therefore, it can be stated that black cumin seeds can be used as a natural antioxidant source in the quail diet.

Effects of black cumin (Nigella Sativa) seed meal on growth performance, blood and biochemical indices, meat quality and cecal microbial load in broiler chickens

Black cumin seed (Nigella Sativa) meal (BCSM) is by-products resulting from the extraction of black cumin seed oil. It contains valuable functional nutrients such as proteins, dietary fibers and phytochemicals. The objective of this study was to investigate the effects of different levels of BCSM in broiler diets on productive performance, oxidative status, immune response, qualitative characteristics of meat, and caecal microbial population. A total of 400 one-day-old male broiler chickens (Ross 308) were allotted into four groups in ten replicates of 10 chicks each. The control group was fed a basal diet without BCSM, whereas BCSM-20, BCSM-40, and BCSM-60 groups were fed diets containing BCSM (20, 40, and 60 g/kg diet, respectively) for 42 days. Results showed that the inclusion of BCSM at all three levels reduced the feed conversion ratio, mortality and breast meat content of MDA, LPO, and lipid. The BCSM-40 and BCSM-60 groups increased body weight gain, RBCs count, HGB, and HCT and reduced the ALP concentration in serum of birds. Moreover, BCSM at all three levels, enhanced the WBCs count, IgG, and IgM and reduced ALT, TC, and TG levels in serum of birds. Furthermore, a significant increase in LYM and IgA content and reduce in HET, HET / LYM ratio, and AST by BCSM supplementaion at 60 g/kg level compared to the other groups.BCSM-60 group had higher GSH-Px, T-SOD, and CAT in serum, lower MDA in liver and greater values of pH and DM of the breast meat. BCSM-40 and BCSM-60 groups enhanced the GSH-Px content in liver and breast, T-SOD in liver, and reduced MDA in serum. Moreover, BCSM-40 and BCSM-60 groups compared to control enhanced values of CP, ash, total volatile bases nitrogen (TVBN) contents, redness, juiciness, tenderness, taste, aroma, and reduced lightness of breast meat. BCSM supplementation at all three levels increased yellowness values of breast meat of birds. A reduction in caecal coliform and E. coli population by 40 and 60 g/kg of BCSM supplementation. Moreover, BCSM supplementation at all three levels reduced the caecal total yeast and molds count population. In conclusion BCSM supplementation has a multi-fold benefit: it improved the broiler's performance traits, increases antioxidant, immune, and meat quality and reduced pathogenic bacteria papulation. It should, therefore, be considered a good supplement in the broiler industry.

Effects of black cumin (Nigella sativa L.) seed on growth performance, blood parameters, liver oxidant/anti-oxidant levels and fatty liver syndrome in quails.

This research aimed to evaluate the effect of different doses of black cumin (Nigella sativa L.) seed (BCS) on growth performance, blood parameters, liver oxidant/anti-oxidant levels and fatty liver syndrome in quails. Four hundred and thirty-two unsexed (male and female) three-day-old Japanese quail (Coturnix coturnix japonica) chicks were divided into four treatment groups (108 chicks per group) with six replicates (18 chicks per replicate). Control and experimental groups were fed for 35 days with basal quail feed including 0.00, 0.50, 1.00 and 2.00% BCS supplement, respectively. At the end, a total of 96 quails, 24 from each group (12 females and 12 males) were slaughtered. The BCS-addition did not affect the growth performance in the experimental groups compared to the control group. Addition of BCS to the diet significantly decreased serum aspartate aminotransferase, lactate dehydrogenase and urea amounts compared to the controls. Whereas, cholesterol decreased significantly with the addition of only 1.00% and low-density lipoprotein with the addition of 0.50 and 1.00% BCS compared to the controls. Liver glutathione levels significantly elevated in 0.50 and 1.00% BCS fed groups; while, glutathione peroxidase levels significantly decreased in 1.00 and 2.00% BCS fed groups. Adding 1.00 and 2.00% BCS to the feed reduced fatty liver incidence in male quails. It is concluded that adding 0.50 and 1.00% BCS positively affects the blood and liver parameters; therefore, BCS may be suggested as an anti-oxidant source to help protect hepatocytes against tissue damage as it has a significant effect on maintaining oxidant and anti-oxidant balance.

The Effect of Black Cumin (Nigella sativa) on the Caspase-3 Expression and the Number of Testic Sertoli Cells in Balb/C Male Mouses Exposed to Diazinon

The Effect of Black Cumin (Nigella sativa) on the Caspase-3 Expression and the Number of Testic Sertoli Cells in Balb/C Male Mouses Exposed to Diazinon

THE EFFECT OF BLACK CUMIN (Nigella sativa) SUPPLEMENTATION THROUGH DRINKING WATER ON THE HISTOLOGY OF SMALL INTESTINE AND LARGE INTESTINE OF BROILER CHICKENS

This study aimed to determine the effect of black cumin (Nigella sativa) supplementation through drinking water on the histology of broiler chickens’ small intestine and large intestine. The research was conducted from April-September 2020 in a cage facility of the Integrated Field Laboratory, Faculty of Agriculture, University of Lampung. This research used a completely randomized design with four treatment groups and three replications (five broilers per replication) with a total of 60 male broilers. The treatments were drinking water without Black Cumin (P0, control); drinking water with Black Cumin 36 mg/kg BW/day (P1); 72 mg/kg BW/day (P2); and 144 mg/kg BW/day (P3). Three broilers from each group were randomly necropsied at 31 days old, and samples of the small intestine (duodenum, jejunum, and ileum) and large intestine were fixed with 10% formalin solution and sent to the Lampung Disease Investigation Center for histological preparations. The observation of preparations was carried out microscopically using the Leica DM500® Binocular Microscope to accurately calculate various parameter sizes. The results were analyzed statistically with one way Analysis of Variance at significant level 5% and if proven significant, then a Tukey test was conducted. The results of this study were that the supplementation of black cumin 72 mg/kg BW/day through drinking water could significantly increase (P0.05) 1) the average sizes of villi height and villi area of small intestine (duodenum, jejunum, ileum) and large intestine (colon) of broiler chickens; 2) the average sizes of basal villi width, villi apex width, and gland diameter of broiler duodenum; and 3) the average size of apex villi width of broiler colon. The conclusion of this study was the supplementation of black cumin at dose of 72 mg/kg BW/day through drinking water could increase the histological sizes of the small intestine and large intestine of broilers.

Effects of Black Cumin (Nigella sativa L.) on patients with cancer and tumor: A systematic Review

Experimental studies demonstrated a positive effect of administration of Nigella sativa L. (Back cumin) and its active chemical components on cancer and tumor through the antioxidant and anti-cancer activity. This study aimed to determine the beneficial effect of the use of black cumin in patients with cancer and tumor. This systematic review includes 4 randomized controlled trials that investigated the effect of the administration of black cumin in human cancer. Articles were searched in PubMed, Cochrane library, Semantic scholar and directory of open access journal (DOAJ), open grey and grey literature report databases for studies from 1983 to 2020 before May using the following keywords, Nigella sativa , black cumin, cancer, tumor, etc. The results examined that N. sativa is much effective in treating breast cancer, gastrointestinal cancer, brain tumor, and acute myeloid leukemia. According to the limited evidence from the study, black cumin may have favorable effects on cancer and tumor. However, more research is needed on different types of cancer to confirm and establish the above findings.

BLACK CUMIN (NIGELLA SATIVA) EFFECT ON BLOOD PRESSURE, MEAN ARTERIAL PRESSURE, PROTEINURIA IN PREECLAMPTIC MODEL RATS

Objective: This research aimed to show effect of black cumin (nigella sativa) on blood pressure, mean arterial pressure (MAP), proteinuria in preeclamptic model rats.&#x0D; Methods: This is analytical research with true experimental design in laboratory pregnant female rats (Rattus norvegicus), which get black cumin seed extract (Nigella sativa) at a dose of 500 mg/kg/day and 2000 mg/kg/day. Treatment of all samples was performed simultaneously and during the treatment was observed using Postest Only Control Group Design. The research was conducted at Biology Laboratory in July 2019. To assess the comparison of parameters (systolic and diastolic blood pressure, mean arterial pressure and proteinuria) between groups the ANOVA test was used if the data were normally distributed and Kruskal Wallis test was used if the data were abnormally distributed.&#x0D; Results: Systolic and diastolic blood pressure and MAP decreased in preeclampsia models rats by administering 500 mg (P1) and 2000 mg (cumin) black cumin extract (P2). However, a dose of 2000 mg black cumin extract had a more significant decrease in systolic blood pressure and MAP. The results of this research indicate that all treatment groups showed improvement after day 9 of the administration of nigella that no treatment group showed proteinuria.&#x0D; Conclusion: Black cumin is proven to reduce systolic and diastolic blood pressure, Mean Arterial Pressure and proteinuria.

The Effect of Black Cumin On Body Weight, OAE Examination and Histopathology of Organ Corti Male White Rats Inducted by Streptomycin

Introduction: Streptomycin is an aminoglycoside type of antibiotics. It is used as a first line treatment for tuberculosis (TB). Streptomycin also cause ototoxicity to its long term user as a fatal side effect. Black cumin (N. sativa) is an herbal plant that is widely consumed and contains thymoquinine as an active compound. Thymoquinine can reduce oxidative stress and increase antioxidant defences in the body. The objecive is to evaluate the relationship and differences of administration of black cumin (N. sativa) to body weight, optoacoustic emission test and the degree of the Organ Corti damage induced by streptomycin in Wistar rats using histopathological examination. Method: In-vivo experimental method using 25 wistar rats (Rattus norvegicus) with 5 treatments group, group K0(control), P1 (Streptomycin 20mg/kgBW/day IM), P2 (Streptomycin IM with low-dose black cumin), P3 (Streptomycin IM with medium-dose black cumin), P4 Streptomycin IM with high-dose black cumin). The experiment was conducted as a post-test only experimental group design and assessed body weight, SNR values on OAE examination and the degree of damage through Haematoxylin-eosin staining histopathological examination. Result: There were no significant differences in post-experimental weight (p&gt; 0.05) with a p-value: 0.549 between every group (K0 to P4) and there were significant differences between SNR values in OAE examination and the degree of damage to Organ of Corti between every group (p&lt;0.005) with a p: 0.000. There was a strong relationship between OAE examination and the degree of damage to Organ of Corti with p-value: 0.001 and r-value: 0.635. There was a moderate relationship between the treatment group and the degree of Organ Corti damage with p-value: 0.036 and r-value: 0.421. There were also no relationship between body weight and the degree of Organ Corti damage (p: 0.725), between the OAE treatment and treatment groups (p: 0.780), between the treatment group and body weight (p: 0.491) and between body weight and OAE examination (p: 0.465). Conclusion: The hypothesis is proven on the strong relationship between OAE examination and degree of Organ Corti damage and also on the moderate relationship between treatment groups and the degree of Organ Corti damage

The effect of black cumin (Nigella sativa) extract on spermatozoa morphology of male albino rats (Rattus norvegicus) after induced with 2-Methoxyethanol

The purpose of this study was to determine the effect of 2-ME and administration of black cumin extract on sperm motility of male white rats. The research method used a completely randomized design (CRD) of 24 male white rats. The 2-ME solution is given intraperitoneally, and black cumin extract is given orally. The samples were divided into 6 groups, treatment given for 21 days. Data analysis used One Way ANOVA and continued with Duncan’s test. The results, after induced 2-ME spermatozoa morphology mean as much as 31.25%, after being given average black cumin extract spermatozoa morphology of 89.75%, after administration of 2-ME and black cumin extract dose of 1.2 g/kgBW average morphology of spermatozoa 35.75%, the dose of 2.4 g/kgBW mean morphology of spermatozoa was 47.00%, while the dose of 3.6 g/kgBW resulted in an increase in morphology of spermatozoa by 57.25%. Conclusion, 2-ME induction can reduce the morphology of male white rat spermatozoa. While the administration of black cumin extract can improve the morphology of male white rat spermatozoa. The administration of black cumin extract at a dose of 3.6 g/kgBW after 2-ME induced can improve the morphology of the sperm and is significantly different.

Effect of Black Cumin (Nigella sativa) Extracts in Inhibiting of the Mutagenic Activity of Mitomycin C in Albino Mice

The aim of this study is to investigate the ability of black cumin (Nigella sativa) aqueous extracts in reducing the genotoxic effects induced by mitomycin C (MMC) in male mice Mus musculus (balb/c strain). Nigella sativa (N. sativa) has been widely used as a medicinal plant that treats different diseases. To determine the genotoxic effects of mitomycin C, the mitotic index of somatic and germ cells and chromosomal aberrations (chromatid breaks, chromosome breaks, and ring chromosomes) were tested. Twenty-five animals were divided into three main groups: group one was used as a negative control treated with buffer saline, group two was used as a positive control treated orally with mitomycin C (2 mg/kg b. w.) for two days; group three, which was divided into three sub groups, was treated orally with three different doses of N. sativa extracts (50, 100, 150 mg/kg b. w.) for one week, and then treated with mitomycin C for two days. The results of this study showed a protective role of N. sativa effecting a significant increase (P<0.05) of the frequency of mitotic index of both somatic and germ cells. Additionally, N. sativa may improve therapeutic efficiency of mitomycin C by inhibiting the chromosomal aberrations.

Chitosan/Octadecylamine-Montmorillonite Nanocomposite Containing Nigella arvensis Extract as Improved Antimicrobial Biofilm Against Foodborne Pathogens

The objective of this study was to develop inexpensive and facile nanocomposites based on chitosan and organo-clay with the antimicrobial affectivity that provide the serious challenges caused by bacterial infections in various products such as food packaging materials. The chitosan with octadecylamine montmorillonite (ODA-MMT) nanocomposites by supplementing 1, 2.5, and 5 w% Nigella arvensis seed (black cumin) extract (CMBC-1, CMBC-2.5, and CMBC-5) were prepared chitosan from ionic liquid solutions in the presence of ODA-MMT and black cumin extract suspension. The effect of black cumin with different content on the structure and antimicrobial activity of the nanocomposite have been investigated. The interactions between the chitosan matrix, ODA-MMT, and black cumin extract at different conditions were characterized both physicochemically (FT-IR, SEM, and XRD) and biologically (antimicrobial). The results indicated that the formation of exfoliated nanostructure of nanocomposites was provided by loading of nanodispersed clay in matrix. Antimicrobial activity of CMBC nanocomposite film was evaluated using disc diffusion method against Gram-negative bacteria Escherichia coli ATCC 25922 and Salmonella enterica serotype Typhimurium SL 1344 and Gram-positives Staphylococcus aureus ATCC 25923 and Streptococcus mutans ATCC 25175. The antimicrobial activity studies of the CMBCs illustrated that the nanocomposites could more strongly inhibit the growth of the tested Gram-negative bacteria than Gram-positive bacteria within increased content of black cumin from 1 to 5 w%. To our knowledge, this is the first report on the antimicrobial effect of CMBC nanocomposite film. Such biomaterials within nontoxic and inexpensive properties will thus have great potential applications in the development of new packing materials that can effectively prevent the antimicrobial formation.

Some microbiological, physicochemical and ripening properties of Erzincan Tulum cheese produced with added black cumin (Nigella sativa L.).

The effects of black cumin (BC) at 0, 1 or 2% in Erzincan Tulum cheese (Tulum cheese) on its microbiological, chemical and proteolysis properties during ripening were investigated. The addition of BC caused an increase in the dry matter, protein, ash, total nitrogen (TN), water-soluble nitrogen (WSN) (% of TN) (ripening index), 5% phosphotungstic acid soluble nitrogen (PTA-SN) (% of TN), and 12% trichloroacetic acid soluble nitrogen (TCA-SN) (% of TN) concentrations compared to BC-free (control) cheese. Additionally, the addition of BC caused a decrease in coliforms, yeasts & moulds, fat-in-dry matter (FDM), pH, and acidity. The ripening period had an increasing effect on the dry matter, protein, FDM, salt, salt-in-dry matter (SDM), ash, acidity, TN, WSN, PTA-SN and TCA-SN concentrations. In addition, the ripening period had a decreasing effect on coliforms, yeasts & moulds, and pH. The count of Staphylococcus aureus in all Tulum cheeses made of raw sheep's milk was <2 log cfu/g, ripening was faster and favourable Tulum cheese was produced. Therefore, 2months after adding 2% BC to Tulum cheese that was produced using raw sheep milk immediately after milking as the original production method, it was found that Tulum cheese can be consumed more safely than coliform bacteria and yeasts & moulds.

Effect of Black Cumin and Arjuna Fruit Extract on Lipid Oxidation in Pork Nuggets during Refrigerated Storage

In this study, the efficacy of arjuna fruit extract (AFE, 1.0%) and black cumin extract (BCE, 1.5%) in retarding lipid oxidation of pork nuggets was investigated and compared with a synthetic antioxidant, butylated hydroxytoluene (BHT, 100 ppm) and control sample during refrigerated storage at 4±1oC for 20 days under aerobic packaging. The total phenolics content of AFE treated cooked pork nuggets was significantly (p 0.05) less in all treated samples as compared to control. The pork nuggets with AFE had significantly (p<0.05) lower mean total aerobic plate count than control. In samples incorporated with AFE and BCE, thiobarbituric acid reactive substances (TBARS) value, peroxide formation, free fatty acids were significantly (p<0.05) lower than control even on 20th day of storage. Sensory evaluation revealed that incorporation of AFE and BCE improved the flavour and overall acceptability scores of pork nuggets than control and prolonged the shelf-life of the product up to 20 days by inhibiting lipid oxidation and microbial growth. From the above findings, it is concluded that AFE at 1% and BCE at 1.5% were effective and could be used as natural antioxidant in retarding lipid oxidation of processed muscle foods.

Hypoglycemic Effect of Black Cumin (Nigella sativa) Seed and Senna Alexandria (Cassia angustifolia) Leaf Extracts on Alloxan-Induced Mice

ABSTRACTThe antihyperglycemic activity of solvent extracts of Nigella sativa seeds and Cassia angustifolia leaves were evaluated on alloxan-induced hyperglycemic mice. Diabetic mice induced by alloxan monohydrate at 150 mg.kg–1 b.w., were administered orally with 1 mL of 0.5 μm Millipore-filtered pure solvent extracts of Nigella sativa seeds and Cassia angustifolia leaves at 1 mL. d–1 for 21 d. The highest antihyperglycemic effect occurred with the N. sativa petroleum ether extract followed by C. angustifolia methanol extract; the N. sativa aqueous extract and C. angustifolia petroleum ether extracts were the least effective in reducing the blood sugar level. Body weight of the diabetic mice treated with the plant extracts was better controlled and returned to normal sooner than control mice. The highest body-weight gain occurred with C. angustifolia methanolic extract and the lowest body-weight gain was observed with C. angustifolia distilled water extract.