Abstract
Objective: This research aimed to show effect of black cumin (nigella sativa) on blood pressure, mean arterial pressure (MAP), proteinuria in preeclamptic model rats.
 Methods: This is analytical research with true experimental design in laboratory pregnant female rats (Rattus norvegicus), which get black cumin seed extract (Nigella sativa) at a dose of 500 mg/kg/day and 2000 mg/kg/day. Treatment of all samples was performed simultaneously and during the treatment was observed using Postest Only Control Group Design. The research was conducted at Biology Laboratory in July 2019. To assess the comparison of parameters (systolic and diastolic blood pressure, mean arterial pressure and proteinuria) between groups the ANOVA test was used if the data were normally distributed and Kruskal Wallis test was used if the data were abnormally distributed.
 Results: Systolic and diastolic blood pressure and MAP decreased in preeclampsia models rats by administering 500 mg (P1) and 2000 mg (cumin) black cumin extract (P2). However, a dose of 2000 mg black cumin extract had a more significant decrease in systolic blood pressure and MAP. The results of this research indicate that all treatment groups showed improvement after day 9 of the administration of nigella that no treatment group showed proteinuria.
 Conclusion: Black cumin is proven to reduce systolic and diastolic blood pressure, Mean Arterial Pressure and proteinuria.
Highlights
Based on the Republic of Indonesia Health Profile in 2017 issued by the Ministry of Health, the maternal mortality rate is 305 per 100,000 live births [1]
The parameters of the PE model rats used in this research include systolic blood pressure of 124.89±1.79 mmHg and Proteuria levels of 2.02±0.29 mg/dl
In the positive control group, there was an increase in systolic blood pressure during monitoring compared to the negative control group
Summary
Based on the Republic of Indonesia Health Profile in 2017 issued by the Ministry of Health, the maternal mortality rate is 305 per 100,000 live births [1]. According to Banten Study II in 2015-2017, 19.1% maternal mortality was due to preeclampsia (PE) or eclampsia [2]. Preeclampsia (PE) is a pregnancy disorder characterized by systemic hypertension and endothelial dysfunction [3]. PE is hypertension (systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mm Hg) arising after 20 w' gestation with or without proteinuria (300 mg or more, in 24 hour urine capacity) [4]. In Indonesia, PE prevalence data are still limited, especially data at the national level. The incidence of PE is around 3-10% [5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
