Extreme heatwaves pose a significant threat to a wide range of environmental, ecological, and social systems. The rapid warming of the Arctic and the Tibetan Plateau (TP), which are the most prominent features in the Northern Hemisphere in the context of climate change, has significantly influenced mid-latitude extreme events in recent decades. This study utilizes observational data and numerical simulations to demonstrate that the variations in Arctic amplification (AA) and TP amplification (TA) play a crucial role in the interannual variability of summer heatwaves (HWs) in the Yangtze River Basin (YRB) (HWs_YRB) region. The HWs_YRB is associated with a zonally oriented barotropic high-pressure system anchored over the YRB region. The spatial distribution and intensity of the HWs_YRB are impacted by the synergistic effects of AA and TA, via a meridional atmospheric tripole pattern and double jets over East Asia. Furthermore, AA primarily impacts the geographical extent of the HWs_YRB, while TA plays a critical role in determining the intensity of the HWs_YRB. Our findings provide an innovative perspective on the linkage between the pronounced warming observed in the Arctic and TP and the occurrence of summer HWs_YRB, enhancing our comprehension of the climatic consequences of the rapid changes in these two geographical regions.