Mycotoxins contamination of feedstuff for aquatic animals is common in regions with humid tropical conditions. In this study Indian white shrimp, Fenneropenaeus indicus , (11.79 ± 1.76 g) were fed with diets containing 0, 20, 50, 100, 200, 400, 800 and 1600 ppb levels of aflatoxin B 1 (AFLB1) for 8 weeks. Final weight, aflatoxin B 1 residue (2-week intervals), Total Hemocyte Count (THC), Total Plasma Protein (TPP), Phagocytic Activity (PA), Survival rate (4-week intervals) were determined. Histopathological alterations in hepatopancreas, midgut and muscle tissues were studied at the end of 4 and 8 weeks. Shrimps fed with the 1600, 800 and 400 ppb concentrations of AFLB 1 exhibited slow growth, and more reddish discoloration disseminated over the body at 4 th week. Growth parameters, survival rate and health indices (THC, TPP) of F. indicus , are affected by the different doses of AFLB 1 in diets. At the end of 8 th week, doses of AFLB 1 in the diets showed negative correlation to final weight, survival rate, THC and TPP (r = - 0.312, -0.603, -0.237 and - 0.649 at P<0.001, respectively). Moreover, significant histopathological alterations in the hepatopancreas, midgut and muscle tissues of exposed shrimps to different levels of AFLB 1 were observed and these alterations are obviously indicated by changes in the health indexes (THC and TPP).