Lack of secondary school education has adverse economic impacts, and this problem is severe for female students who have lower enrollment rates than male students, especially in low-income countries. To better understand the causes for lower female enrollment in secondary schools across the globe, we analyzed socio-economic factors that were likely to influence secondary school female enrollment. Specifically, we evaluated adolescent fertility rate (births per 1,000 women ages 15-19), per capita GDP, government spending on education (% of per capita GDP), and government spending on education (US$ per capita). Inferences on the relationship between secondary school female enrollment and the 4 variables were made from scatter plots, boxplots, regression and correlation analyses. Pearson’s product moment correlation coefficient (r) was used to measure the strength of linear relationships while non-linear monotonic trends were characterized using Spearman’s rank correlation coefficient (rs) . A negative linear correlation (r = -0.798) was observed between female enrollment and fertility rates while a strong positive non-linear correlation was observed between government spending on education and female enrollment rates as indicated by a Spearman’s coefficient of 0.799. Overall, our analysis indicated that reducing teenage pregnancies and increasing government spending on education, even to relatively modest levels of $100 – $200 per capita can bring female enrollment rates in the 50 – 75% range which can lead to significant gains both at the personal and national level.