In March 2020, the Saudi government announced that school and university courses were to be held online to control the COVID-19 outbreak. A sudden yet smooth movement occurred from traditional face-to-face classrooms to online courses. This shift influenced the nature of classes, the nature of the interaction, and the participants’ roles. Interaction in online classes is viewed as a form of computer-mediated communication. This paper explores the nature of computer-mediated communication in online courses at one of the major research universities in Riyadh during the COVID-19 pandemic. Using an in-depth qualitative analysis of Walsh’s (2006) framework of Self-Evaluation of Teacher talk, this study examines the nature of classroom discourse and interactions among level six students who took a content course in English and lectures were transcribed for this study. Results answer questions regarding the common interaction modes and features and how efficient they are to encourage participation during Computerized Mediated Communication. Analysis reveals that using traditional interactional features is not suitable in virtual classes.Teacher dominated classes with excessive IRFs patterns do not cultivate interaction in Computerized Mediated Communication. New modes of communication and discursive features using more interactive tools and engaging features such as referential questions promote interaction. Results provide an insight into the nature of interaction in online university classrooms. It also adds to the current literature on Computerized Mediated Communication interaction to enhance the existing practices done in classrooms.