Background:In the early 20th century some unfavorable conditions and trends in science and publishing in R. Macedonia and other countries in the South Eastern Europe (SEE) Region were recognized and it became necessary to act to protect the integrity of science and publishing. The increasing number of scientific journals in biomedicine and published papers in them has not always been matched by increased quality in publishing due to lack of information and education of the scientific community, especially of the young scientists, about ethical principles in research and publishing. In addition, some unethical behavior, fraud and attempts by experts for increasing their scientific productivity in research and publishing their results in scientific journals was recognized.Objective:To present the initiatives, chronology of activities and leading role of Academician Momir Polenakovic towards the establishment and initial development of the Macedonian Association of Medical Editors (MAME) which has a mission for advancing the integrity of science and publishing.Method:A retrospective study based on review of the relevant literature, archive materials, minutes from organizational meetings and workshops and other documentation related to activities in the initial process for establishing and defining the mission and objectives of MAME.Results:The expansion of higher education and inappropriate implementation of the Bologna Declaration and the European Credit Transfer System in R. Macedonia from 2004/2005 contributed to a decline of the study criteria for obtaining higher education diplomas and postgraduate education degrees, as well as numerous frauds in scientific research and publishing activities in biomedicine and other fields. The first meeting of the Initiative Board for organizing an SEE Conference on research and publishing integrity and a workshop for editors of scientific journals was held in the Macedonian Academy of Sciences and Arts (MASA) on Nov. 1st, 2013. In April 2014 two preparatory meetings of the Organizational Board were held and the Workshop for editors of scientific journals and the Constitutional meeting for establishing MAME were held on Apr. 25, 2014. The first President of MAME (with a two-year mandate) was Academician Momir Polenakovic and in 2016 he was elected as the first Honorary President of MAME.Conclusion:The establishment of MAME in April 2014 was an important initiative and strategic decision toward raising awareness among editors of scientific journals and other stakeholders for preventing scientific and publishing misconduct and for educating the scientific community for creating an ethical research environment.