Edinburgh Handedness Inventory Scores Research Articles

Nerve conduction, latency, and its association with hand function in young men.

The median and ulnar nerves have been suggested to play a significant role in hand function; however, there are insufficient data to determine the strength of this association. This study aimed to investigate the correlation between hand function as measured with the Grooved pegboard test (GPT) and conduction velocity and latency of the median and ulnar nerves. We collected convenience samples in the College of Medicine, KSAU-HS. We used GPT to characterize hand function and performed measured nerve conduction velocity (NCV) and latency of the ulnar and median nerves of both hands. We used the Edinburgh handedness inventory (EHI) to determine hand dominance. We recruited 28 healthy medical students aged 20-29 years (mean: 21.46 ± 1.62 years). Most were right-handed (n = 25, 89.3%), with a mean EHI score of 302 ± 210. The mean GPT time was significantly faster in the dominant (65.5 ± 6.4 s) than in the non-dominant (75.0 ± 9.6 s) hand. The NCV for the ulnar nerve of the dominant hand was significantly correlated with GPT (r = -0.52, p = 0.005) while median nerve was not correlated (0.24, p = 0.21). Regression analysis and collinearity test showed that the ulnar NCV explained 20% of the variance in GPT of the dominant hand (R2 = 0.203, p = 0.016). The ulnar nerve conduction velocity, explained 20% of the variance in GPT times of the young men. Performance on this biomarker of neurological health seems to be more influenced by other factors in healthy young individuals.

Asymmetry of the Frontal Aslant Tract Depends on Handedness.

The human brain displays structural and functional disparities between its hemispheres, with such asymmetry extending to the frontal aslant tract. This plays a role in a variety of cognitive functions, including speech production, language processing, and executive functions. However, the factors influencing the laterality of the frontal aslant tract remain incompletely understood. Handedness is hypothesized to impact frontal aslant tract laterality, given its involvement in both language and motor control. In this study, we aimed to investigate the relationship between handedness and frontal aslant tract lateralization, providing insight into this aspect of brain organization. The Automated Tractography Pipeline was used to generate the frontal aslant tract for both right and left hemispheres in a cohort of 720 subjects sourced from the publicly available Human Connectome Project in Aging database. Subsequently, macrostructural and microstructural parameters of the right and left frontal aslant tract were extracted for each individual in the study population. The Edinburgh Handedness Inventory scores were used for the classification of handedness, and a comparative analysis across various handedness groups was performed. An age-related decline in both macrostructural parameters and microstructural integrity was noted within the studied population. The frontal aslant tract demonstrated a greater volume and larger diameter in male subjects compared with female participants. Additionally, a left-side laterality of the frontal aslant tract was observed within the general population. In the right-handed group, the volume (P < .001), length (P < .001), and diameter (P = .004) of the left frontal aslant tract were found to be higher than those of the right frontal aslant tract. Conversely, in the left-handed group, the volume (P = .040) and diameter (P = .032) of the left frontal aslant tract were lower than those of the right frontal aslant tract. Furthermore, in the right-handed group, the volume and diameter of the frontal aslant tract showed left-sided lateralization, while in the left-handed group, a right-sided lateralization was evident. The laterality of the frontal aslant tract appears to differ with handedness. This finding highlights the complex interaction between brain lateralization and handedness, emphasizing the importance of considering handedness as a factor in evaluating brain structure and function.

Examining Variations Between Everyday Life Handedness and Lateral Preferences for Sport-Specific Skills in Children

ABSTRACT Purpose: This study aimed to analyze both sport-specific lateral preferences and handedness for everyday life tasks among school-aged children. Method: A total of 533 children (254 males and 279 females) aged 6 to 15 years old were assessed. Children’s handedness was determined according to the laterality score from Edinburgh Handedness Inventory (EHI), while lateral preferences were assessed for 16 different sport-specific tasks. Results: The percentage of children with a left hand preference was lower for unilateral (10.5–14.3%) than for bilateral (19.5–31.7%) tasks. An increased prevalence of left-sided preference was also obtained for foot tasks (13.3–26.8%) and rotation along the vertical axis (28.5%). Similarly, hand preference for unilateral sport-specific tasks and EHI scores were largely correlated (r = 0.551–0.630), while these correlations were lower for bilateral hand tasks (r = 0.148–0.418), foot tasks (r = 0.201–0.386) and rotation preference (r = 0.129). Moreover, left-handed children evidenced less lateralized behavior for sport-specific tasks than right-handed children. Conclusions: The current study has shown that sport-specific lateral preferences and their correlations with handedness vary considerably depending on the task and individual characteristics in developmental ages. These findings emphasize the relevance of task-specific assessments of lateral preferences when looking at sports skills during childhood.

Nicotine smoking is associated with impaired cognitive performance in Pakistani young people.

Nicotine smoking is the most common mode of tobacco smoking among young people. It affects the areas of the brain associated with memory, attention, and learning. This study has investigated the effect of nicotine smoking on cognitive performance. One hundred male volunteers (50 nicotine smokers and 50 nonsmokers) aged 18–30 years with similar socioeconomic backgrounds were recruited for this study. Clinical history of participants was obtained using a questionnaire. Their brain health and handedness were determined using the Mini Mental State Examination (MMSE) and the Edinburgh Handedness Inventory (EHI), respectively. The dependent variables examined in the study were attention-switching tasks (AST), pattern recognition memory (PRM), and choice reaction time (CRT). These parameters were assessed using the Cambridge Neuropsychological Automated Battery (CANTAB). The average ages of participating smokers and nonsmokers were 24.02 ± 3.41 years (mean ± standard deviation) and 22.68 ± 1.87 years, respectively. MMSE and EHI scores of smokers were 28.42 ± 1.09 and 99.75 ± 1.77, respectively; for nonsmokers, these scores were 28.54 ± 1.34 and 98 ± 1.91, respectively. The mean score for AST correct latency/delay was significantly higher (p = 0.050) in smokers (620.26 ± 142.03) than in nonsmokers (570.11 ± 108.39). The percentage of correct AST trials was significantly higher (p = 0.000) in nonsmokers (96.95 ± 2.18) than in smokers (83.75 ± 11.22). The PRM percent correct were significantly higher (p = 0.000) of nonsmokers (93.42 ± 8.34) than of smokers (79.75 ± 13.44). The mean correct latency for CRT was significantly higher (p = 0.009) in smokers (509.87 ± 129.83) than in nonsmokers (455.20 ± 65.73). From this data, it can be concluded that nicotine smoking is linked with impaired cognitive functions in smokers.

Handedness measures for the Human Connectome Project: Implications for data analysis

ABSTRACT Open data initiatives such as the UK Biobank and Human Connectome Project provide researchers with access to neuroimaging, genetic, and other data for large samples of left-and right-handed participants, allowing for more robust investigations of handedness than ever before. Handedness inventories are universal tools for assessing participant handedness in these large-scale neuroimaging contexts. These self-report measures are typically used to screen and recruit subjects, but they are also widely used as variables in statistical analyses of fMRI and other data. Recent investigations into the validity of handedness inventories, however, suggest that self-report data from these inventories might not reflect hand preference/performance as faithfully as previously thought. Using data from the Human Connectome Project, we assessed correspondence between three handedness measures – the Edinburgh Handedness Inventory (EHI), the Rolyan 9-hole pegboard, and grip strength – in 1179 healthy subjects. We show poor association between the different handedness measures, with roughly 10% of the sample having at least one behavioural measure which indicates hand-performance bias opposite to the EHI score, and over 65% of left-handers having one or more mismatched handedness scores. We discuss implications for future work, urging researchers to critically consider direction, degree, and consistency of handedness in their data.

Validity and Reliability Analysis of Turkish version of Edinburgh Handedness Inventory

Objectives: The Edinburgh Handedness Inventory (EHI) is the most common tool in determining handedness. It consists of 10 tasks and asks the patient which hand he prefers for those activities. The validity and reliability of the Turkish version of the scale have not been analyzed. Therefore, the aim of this study was to adapt the EHI for Turkish language and to test its validity and reliability. Methods: The translation of EHI into Turkish was performed by 2 physiotherapists and back-translation was done by a physiotherapist with native English. Healthy young volunteers were included in the study for the validity and reliability analysis. Age, gender and dominant side reported by the participant were recorded. Participants filled the scale twice with a 7-day interval. Test-retest reliability of the questionnaire was analyzed with Pearson's correlation analysis method. Results: A total of 151 participants (113 females and 38 males) included in the study and the average age was 22.6 ± 1.7. Only 11 participants reported their dominant side as left. It was seen that self-reported dominant side completely (100%) matched with the scale-based dominant side. It means that all right-handed individuals had positive EHI scores and all left-handed ones had negative scores. EHI test and re-test scores were correlated in an “excellent” level (r: 0.912; p

Psychometric properties of the Spanish version of the Edinburgh Handedness Inventory in a sample of Chilean undergraduates

An individual’s nervous and cognitive systems are lateralized, and handedness represents a behavioral manifestation of such organization. Therefore, accurately and reliably measuring handedness has repercussion on our understanding of both the human brain and cognition. The Edinburgh Handedness Inventory (EHI) is the most frequently used instrument to measure handedness both in clinical practice and research. We assessed the psychometric properties of the Spanish version of the EHI in a sample of 348 Chilean university students by confirmatory factor analysis. Cronbach’s alpha and composite reliability were calculated to evaluate the internal consistency and reliability of the EHI, while the average variance extracted was estimated to evaluate its convergent validity. A 10-item unifactorial structure was confirmed, with factor loadings ≥0.50, showing excellent goodness-of-fit indicators, very high internal consistency and adequate composite reliability and convergent validity. Socio-demographic variables (sex, area of residence and belonging to an indigenous people or community) did not significantly modulate the EHI scores. Overall, by using this validated version of the EHI to accurately and reliably measure handedness in the greater Spanish population, researchers will be able to produce robust data to tackle the still open questions of lateralization in human cognitive and neural architecture.

Inconsistent handers show higher psychopathy than consistent handers

ABSTRACTThree hundred and forty-two university students completed the Short Dark Triad (SD3) and the Edinburgh Handedness Inventory (EHI). Inconsistent handers showed higher psychopathy scores than consistent handers, and no handedness differences were observed for narcissism or Machiavellianism. Participants were further subdivided by quartile into low, moderately low, moderately high, and high psychopathy groups (non-clinical). Absolute EHI scores were equally distributed among low and moderate groups, but were significantly lower for the high psychopathy group. These findings suggest that inconsistent handedness is only associated with the upper quartile of psychopathy scores. Also, males showed significantly higher psychopathy scores than females, and the ratio of male to female inconsistent handers decreased as psychopathy score increased. No gender × handedness interaction indicated that both female and male inconsistent handers have higher psychopathy scores than consistent handers. Although significant, the effects were small and 99.6% of participants were not in the range of a potential clinical diagnosis. The reader, therefore, is strongly cautioned against equating inconsistent handedness with psychopathy.

Abstract W P138: Hand Asymmetries in the Control of Grasp Force Post-Stroke

Background and Purpose: Stroke survivors have difficulty overcoming deficits associated with grasping ability that differ for their right and left hand. However, grasp force deficits unique to each hand are not clearly characterized. The purpose of this study was to determine right and left hand differences in control of grasp force for individuals who were right handed pre-stroke. Methods: Twenty-one participants (13 with left hemispheric &amp; 8 with right hemispheric stroke) completed clinical assessments and performed hand-grasp tasks using Instrumented Strain Gauges embedded with force sensors. Pre / post stroke hand preference scores were obtained using the self-reported Edinburgh Handedness Inventory (EHI). A right and left hand Reference Force (RF) was based on 20% of the right and left maximum grasp force. The Matching Force (MF) was performed by the opposite hand. Visual feedback represented by a horizontal line on a computer monitor displayed the 20% RF. MF, performed without visual feedback, indicated whether the participant overshot or undershot the RF and was quantified as the Constant Error. Results: EHI scores for right hemispheric stroke patients were 0.86 / 1.00 pre, and 0.92 / 1.00 post stroke, indicating greater right hand use post stroke. EHI scores for left hemispheric stroke patients were 0.91 / 1.00 pre, and 0.59 / 1.00 post stroke, indicating less right hand use and greater left hand use post stroke. The ANOVA showed a significant three-way interaction for matching hand *reference hand* affected side F(2, 38) =4.42, p &lt; 0.05) for constant error. Right hemispheric stroke patients showed left hand MF undershoots for right hand RF (p &lt; 0.05). Left hemispheric stroke patients showed right hand MF undershoots for left hand RF (p &lt; 0.05). Conclusions: Shifts in handedness scores and asymmetries in force matching performance were dependent on lesion location. From a clinical perspective, stroke survivors may not be aware of how hand differences in the control of grasp force influence their ability to perform everyday tasks despite knowing that one hand may be weaker than the other. This suggests using a lesion-side specific treatment technique to improve awareness and function when performing unimanual and bimanual hand-grasp tasks.

Handedness and effective connectivity of the motor system

Handedness denotes the individual predisposition to consistently use the left or right hand for most types of skilled movements. A putative neurobiological mechanism for handedness consists in hemisphere-specific differences in network dynamics that govern unimanual movements.We, therefore, used functional magnetic resonance imaging and dynamic causal modeling to investigate effective connectivity between key motor areas during fist closures of the dominant or non-dominant hand performed by 18 right- and 18 left-handers. Handedness was assessed employing the Edinburgh-Handedness-Inventory (EHI). The network of interest consisted of key motor regions in both hemispheres including the primary motor cortex (M1), supplementary motor area (SMA), ventral premotor cortex (PMv), motor putamen (Put) and motor cerebellum (Cb).The connectivity analysis revealed that in right-handed subjects movements of the dominant hand were associated with significantly stronger coupling of contralateral (left, i.e., dominant) SMA with ipsilateral SMA, ipsilateral PMv, contralateral motor putamen and contralateral M1 compared to equivalent connections in left-handers. The degree of handedness as indexed by the individual EHI scores also correlated with coupling parameters of these connections. In contrast, we found no differences between right- and left-handers when testing for the effect of movement speed on effective connectivity.In conclusion, the data show that handedness is associated with differences in effective connectivity within the human motor network with a prominent role of SMA in right-handers. Left-handers featured less asymmetry in effective connectivity implying different hemispheric mechanisms underlying hand motor control compared to right-handers.

Awake surgery in low-grade gliomas harboring eloquent areas: 3-year mean follow-up

Low-grade gliomas are slow-growing tumors invading eloquent areas and white matter pathways. For many decades these tumors were considered inoperable because of their high tropism for eloquent areas. However, the young age of the patients and the inescapable anaplastic transformation have recently suggested more aggressive treatments. We analyzed the neurological and neuro-oncological outcome of 12 patients who underwent surgery fully awake for the resection of LGG, harboring eloquent areas. 10 right- and 2 left-handed patients underwent pre-operative assessment: Karnofsky Performance Status, Edinburgh Handedness Inventory Score; neuropsychological and neurophysiological evaluations, according to the tumor location. During surgery we performed: sensory-motor-evoked potentials, continuous electro-corticography and bipolar/monopolar cortico-subcortical mapping during neuropsychological tests. The resection rate was calculated with neuro-imaging elaboration software. No permanent post-operative deficits were reported; 2 patients improved after surgery. No impairment of cognitive functions was reported. The KPS improved in 8 patients and was steady in the others. The mean resection rate was 78.3%. The resection allowed the control of pre-operative seizures without increasing the drug intake. Awake surgery allowed a good resection rate despite the eloquent location of the tumors, without post-operative deficit. The neuropsychological outcome was unchanged after surgery. The resection seems to improve seizure control. All the patients came back to normal life and work. In conclusion, awake surgery is reliable and feasible in removal of LGG, even if invading the main eloquent areas and networks. All the patients experienced a normal life after surgery, without permanent deficits.

Neurodevelopmental Correlates of Paraphilic Sexual Interests in Men

The etiology of anomalous, or paraphilic, sexual preferences in men is unclear although a growing literature points to their prenatal neurodevelopmental ontogenesis. The present study explored whether this was also apparent in a community sample of 200 heterosexual men by examining their sexual fantasies using the Wilson Sex Fantasy Questionnaire (WSFQ) and several demographic and somatic neurodevelopmental markers, including sibling sex composition, handedness, maternal and paternal age at birth, second to fourth finger length ratios, and fluctuating asymmetry of finger lengths and wrist widths. Responses to the WSFQ were used to quantify the extent of paraphilic interest by computing a variance-quotient (or VQ) previously shown to differentiate paraphilic from conventional heterosexual males. High paraphilic scorers had a significantly greater number of older brothers, higher right-hand 2D:4D, and a trend for lower Edinburgh Handedness Inventory (EHI) scores compared to low-paraphilic scorers. Correlational analysis revealed a significant positive association of VQ scores with number of older brothers and significant negative associations with number of younger brothers and EHI scores (elevated paraphilic interests were correlated with elevated non-right handedness). Correlations between VQ scores and other variables were not significant. It is suggested that processes such as developmental instability and maternal immunity may play a role in variant sexual preferences among otherwise healthy heterosexual men.

Neural Responses to Human Voice and Hemisphere Dominance for Lexical-semantic Processing

In our previous functional magnetic resonance imaging (fMRI) study, we determined that there was distinct left hemispheric dominance for lexical-semantic processing without the influence of human voice perception in right-handed healthy subjects. However, the degree of right-handedness in the right-handed subjects ranged from 52 to 100 according to the Edinburgh Handedness Inventory (EHI) score. In the present study, we aimed to clarify the correlation between the degree of right-handedness and language dominance in the fronto-temporo-parietal cortices by examining cerebral activation for lexical-semantic processing. Twenty-seven normal right-handed healthy subjects were scanned by fMRI while listening to sentences (SEN), reverse sentences (rSEN), and identifiable non-vocal sounds (SND). Fronto-temporo-parietal activation was observed in the left hemisphere under the SEN - rSEN contrast, which included lexical-semantic processing without the influence of human voice perception. Laterality Index was calculated as LI = (L - R)/(L + R) x 100, L: left, R: right. Laterality Index in the fronto-temporo-parietal cortices did not correlate with the degree of right-handedness in EHI score. The present study indicated that the degree of right-handedness from 52 to 100 in EHI score had no effect on the degree of left hemispheric dominance for lexical-semantic processing in right-handed healthy subjects.

Sinistrality in subtypes of schizophrenia

Sinistrality, characterized by an excess of non-right-handedness, has been reported in schizophrenic patients, but the findings are controversial. Aim. As sinistrality could be linked to a failure of hemisphere specialization in schizophrenia that would translate into language disorders, sinistrality was found out in disorganized and positive schizophrenic patients characterized by language disorders. Methods. Seventy-three schizophrenic patients (DSM IV) and 81 controls were evaluated with the Edinburgh Handedness Inventory (EHI). Patients were evaluated and classified into five subtypes (deficit, positive, disorganized, mixed and residual) with the Positive and Negative Syndrome Scale and the Schedule for the Deficit Syndrome. Results. Disorganized patients had a significantly more severe sinistrality in comparison to the deficit, residual and mixed subtypes and controls. A negative correlation was found between the disorganization and the EHI scores ( r = – 0.34; P < 0.01). A significantly more severe sinistrality was also observed in the positive subtype in comparison to controls, but there was no correlation between hallucinatory and EHI scores ( r = 0.06). Conclusion. The findings provided further evidence that the defects in the normal process of lateralization observed in schizophrenia affects primarily disorganized patients.

Edinburgh Handedness Inventory scores: Caucasian and American Indian college students.

Laterality Quotients for 80 American Indian college students were less right-biased than those for 80 Caucasian college students on the Edinburgh Handedness Inventory. Oldfield's 1971 empirically derived deciles for the Edinburgh Handedness Inventory were used to assign decile levels to the data. Deciles were then used to assign data to one of three proposed handedness phenotype classifications. Phenotype classifications were based on Annett's 1985 proposed distribution for a single gene theorized to underlie human handedness. Chi-squared goodness-of-fit analysis showed that the data for Caucasian college students did not differ significantly from what would be anticipated by Annett's model, but American Indians differed significantly. Results provide empirical support for the hypothesis that frequency distributions for Annett's hypothesized right-shift gene may differ across racial groups.