AbstractAs pixel resolution continues to increase in images acquired from different sensors, the measurement of the correlation between pixels and their properties requires numerous processing steps over multiple iterations. Quantum image processing (QIP) is a technology capable of processing exponentially large volumes of data within polynomial time. One such application is image fusion. In the field of radiography, computerized tomography (CT) images provide the structural information of bone tissues, and magnetic resonance MR images can provide the visualization of gray‐scale anatomical structures of soft tissues. With the help of CT and MR fusion, a composite image can be obtained containing information on both hard and soft tissues. Clinicians often have to switch between these modalities to trace various patterns for effective staging and diagnosis of various oncological diseases. In this study, a multilevel filtering‐based image fusion algorithm that efficiently fuses information from CT and MR images into a single image has been proposed. First, source images are processed with a rolling guidance filter, and the detail layer is calculated. The base layer is then computed using guided filtering to ensure a high level of edge preservation. Furthermore, to minimize noise and artifacts, the detail layers are fused using the Karhunen–Loeve transform, and the base layers are combined using the weighted superimposition principle. Experimental results demonstrate that the proposed methodology is subjectively more efficient than the existing state‐of‐the‐art methods.