In order to obtain a panoramic image which is clearer, and has more layers and texture features, we propose an innovative multi-focus image fusion algorithm by combining with non-subsampled shearlet transform (NSST) and residual network (ResNet). First, NSST decomposes a pair of input images to produce subband coefficients of different frequencies for subsequent feature processing. Then, ResNet is applied to fuse the low frequency subband coefficients, and improved gradient sum of Laplace energy (IGSML) perform high frequency feature information processing. Finally, the inverse NSST is performed on the fused coefficients of different frequencies to obtain the final fused image. In our method, we fully consider the low frequency global features and high frequency detail information in image by using NSST. For low-frequency coefficients fusion, we can also obtain the spatial information features of low-frequency coefficient images by using ResNet, which has a deep network structure. IGSML can use different directional gradients to process high-frequency subband coefficients of different levels and directions, which is more conducive to the fusion of the coefficients. The experiment results show that the proposed method has been improved in the structural features and edge texture in the fusion images.