The histories of 4 infants with cystic fibrosis of the pancreas who developedhypoproteinemia and edema are recorded. Twenty-two additional instances of this clinical pattern have been found in the literature. The majority of these patients had the onset of edema at about 2 months of age, and in the majority of instances their diet consisted either of human milk or a soybean milk preparation. The relationship between CFP and diet and the development of hypoproteinemic edema is discussed.