The results of a theoretical analysis and experimental study of unsteady forced convection with turbulent flow in the thermal entrance region of a circular duct, subjected to a periodically varying inlet temperature, are presented. The related unsteady energy equation for the thermal entrance region is analytically solved under a general boundary condition of the fifth-kind, accounting for the effects of both external convection and wall heat capacitance. Together with empirical models for expressing both eddy viscosity and turbulent velocity profiles, the generalized integral transform technique is used to provide hybrid analytical-numerical solutions for the thermal response of the fluid with a prescribed accuracy. An experimental setup was built and used to validate the mathematical modeling wherein the thermal response of the fluid is obtained in terms of amplitudes and decay indices with respect to the inlet condition for fully developed turbulent flow, due to a sinusoidal variation of the inlet temperature. Satisfactory agreement prevailed between the theoretically and experimentally determined heat transfer characteristics for a succession of axial positions, thereby establishing the theoretical model and numerical technique. To further enhance the model's practical applicability to engineering problems, the analytical technique is extended in obtaining results on the effects of the modified Biot number, fluid-towall thermal capacitance ratio, and the Reynolds number, on the thermal response of the fluid within the temperature field, which are presented in tabular forms.