The need for a qualitative update of the characteristics of labor capital in the conditions of digitalization of the region's economy is due to the search for the necessary opportunities for accumulation and use of human potential, preservation and prolongation of the life cycle of labor resources. The modification of labor capital is expressed in increasing the role and transformation of the qualities of an employee not only as an object, but also as a subject of the labor process, changing its characteristics and socially responsible orientation. The purpose of this study is to analyze the process of qualitative renewal of the characteristics of labor capital in the conditions of digitalization and socialization of the economy of the region, to identify the main prerequisites, determinants and factors of its modification. The study revealed the causes and factors of qualitative renewal of labor capital in the conditions of digitalization and socialization of the economy, including: improvement of the structure of labor capital, development of social factors of the organization, improvement of working conditions, development of labor and social activity. The main characteristics and sources of labor capital development are identified: educational and professional level, health and professional longevity, sanitary and hygienic conditions and a healthy production environment, labor and creative activity, social responsibility and participation in management. The authors determined that the qualitative renewal of labor capital is determined, first of all, by changes in the structure of organizations and working conditions, the type and characteristics of employees, the role of the collective in creating economic wealth, social progress and is expressed in increasing the role of the employee's personality, changes in his socially responsible orientation. The active participation of personnel in production management is an important element of the humanization of social and labor relations and the modification of labor capital. Innovations in labor and employee characteristics are due to the requirements for personnel from modern advanced generations of labor tools, innovative technologies, and digitalization of the economy. Modern innovative production and digitalization of the economy require constant professional development. In addition, there is a need for competent employees with better professional abilities. The human factor is turning into the main source and impetus of economic and social development.