Objective To explore the real burden experience and feelings of the caregivers of patients with advanced pancreatic cancer in the process of care. Methods Totally 9 caregivers of patients with advanced pancreatic cancer were selected and investigated by in-depth interviews. Results Five major themes were found: Psychological burden, Physiological burden, Lack of knowledge, emotion, and economic support system, Challenges to personal life. Conclusions The caregivers of patients with advanced pancreatic bear the burden in Psychology, Physiology and personal life,and lack of emotional, economic and social support to different degrees at the same time. Doctors and nurses should pay attention to the caregivers, help them solve the difficulties, and provide scientific and effective nursing intervention. Key words: Pancreatic neoplasms; Caregivers; Burden experience; Qualitative study