This study explores the multifaceted impact of economic indicators, financial market dynamics, and technological innovations on supply chain efficiency and resilience. Through comprehensive quantitative analyses, including panel data regression, multivariate regression, and time-series analysis, we dissect the relationship between GDP growth rates, inflation, unemployment rates, interest rate fluctuations, exchange rate volatility, stock market trends, and supply chain performance metrics. Our findings highlight a significant correlation between economic growth and supply chain efficiencies, the exacerbating effect of inflation and unemployment on supply chain costs and demand, and the nuanced impacts of financial market dynamics on supply chain financing and operational strategies. Moreover, we delve into the transformative potential of digitalization, automation, blockchain technology, and advanced analytics in mitigating risks associated with economic fluctuations and financial uncertainties. The empirical evidence suggests that technological innovations not only enhance supply chain resilience but also offer strategic advantages in navigating the complexities of global economic landscapes. This study underscores the critical need for adaptive strategies that leverage technological advancements to sustain supply chain competitiveness in an era of economic and financial volatility.