The economic power dispatch (EPD) is an integral part of the power system, and the major roles and purpose of its use are for achieving a reliable and efficient operation out of power system generation networks, and this operation should be obtained by minimizing the generator fuel cost. Getting optimal solutions to EPD problem requires efficient optimization algorithms. Novel Bat Algorithm (NBA) is one of the most recent methods and it has already proven its efficiency and reliability for solving the EPD problem. This paper proposes Novel Bat Algorithm (NBA) in order to solve the EPD problem based on the large scale power system. The NBA has proved its efficiency and it gave a perfect performance for small-scale systems compared with the original Bat algorithm (BA), because of considering the Doppler Effect and assumed that bat can move between various habitats. The study of the EPD for large-scale power systems is more important than study it for small ones, because all power systems in countries are considered large networks. This is why all modern studies focus on the study of EPD for large systems. To test the performance of NBA during small and large scale power system, we have applied it to many systems, including 3-thermal units, 6-thermal units, 31-Iraqi thermal units and IEEE 40-thermal units respectively, with transmission losses and generator limits, and we have made a comparison of the obtained results of NBA with other optimization methods. The Iraqi thermal units have been utilized as a new data.