In modern conditions of chaoticization of the system of international economic relations and foreign economic activity of business entities, the tasks of improving the management of foreign economic activity of enterprises by the state and the formation of its embedded mechanisms to ensure the protection of state security in the world market are actualized. The purpose of the article is to analyze the topical issues of foreign economic activity transformation in the context of global instability. According to the author, in the system of state regulation of foreign economic activity of an enterprise, the implementation of an integrated foreign economic activity management system will be timely, which will significantly offset the problems existing in subjects of foreign economic activity related to external factors. However, it is impossible to quickly adjust to dynamically changing conditions and ensure management consistency, increase the efficiency of foreign economic activity of domestic enterprises and protect state economic security. The main goal of the transformation, according to the author, is to provide the necessary transparency and flexibility in the management system of foreign economic activity both at the state level and at the level of a specific subject of foreign economic activity, which is very important in the context of growing instability of the macroeconomic environment. Priorities in the context of growing global instability are to increase the efficiency of foreign economic activity, the competitiveness of the economy and the protection of economic security.