This study explores food insecurity in South Sudan through the lens of young entrepreneurs, revealing insights into understanding the causes, coping strategies, and innovative solutions. Analyzing survey responses reveals a complicated problem linked to poverty, conflict, climate change, and economic instability. We surveyed 19 standout candidates selected from 325 South Sudanese participants from the United Nations Institute for Training and Research (UNITAR’s) hybrid training on entrepreneurship and agribusiness, who successfully passed the assessment criteria to attend a workshop in Hiroshima, Japan, in February 2024. These participants clearly depicted the dire circumstances, with widespread food insecurity, heavy reliance on humanitarian aid, and prevalent malnutrition, especially in conflict-affected regions like Yambio. Conflict, climate shocks, economic instability, and inadequate infrastructure emerged as primary drivers of food insecurity. Despite these challenges, young entrepreneurs express a keen desire to contribute to solutions, advocating for sustainable agriculture, entrepreneurship, and education initiatives. During conflict, coping strategies vary from reducing meal frequency to diversifying diets and engaging in subsistence farming. The innovative solutions proposed include sustainable agricultural practices, value chain development, and technology adoption. The study underscores the urgent need for comprehensive strategies addressing the root causes of food insecurity while empowering communities and young entrepreneurs to foster resilience. Sustained support in youth agri-business capacity building and entrepreneurial skills development, increased agricultural investment, infrastructure enhancement, and targeted youth empowerment initiatives are emphasized. Through collaborative efforts, South Sudan can progress towards achieving resilience and improving food security.