This paper attempts to investigate the relationship between the growth of gross domestic product and innovation related activities. A panel data analysis is conducted on a sample of eight middle-income countries covering 5-year time period from 2012-2016. The major findings of the study show a significant positive impact of expenditure on education, graduates in science and engineering, knowledge intensive employment, scientific and technical articles, population and foreign direct investments on the growth of gross domestic product. Hence, we conclude that there is a strong relation between innovation-related activities and economic growth in middle-income countries. Therefore, we suggest that middle-income countries should focus more on R&D and innovation related activities to grow and change their income status to higher income levels.