Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) approach, this article investigates 85 articles on economic development collaboration in public administration research, published between 1990 and 2022. Economic development collaboration is the process of interaction among multiple economic development organizations in order to tackle economic development problems that cannot be resolved by single organizations. This systematic review demonstrates seven key aspects of economic development collaboration studies: (1) research questions, (2) collaboration types, (3) empirical designs and methods, (4) antecedents of economic development collaboration, (5) mechanisms of economic collaboration, (6) outcomes of economic development collaboration, and (7) research limitations. Based on these results, this article identifies strengths and weaknesses in economic development collaboration research and concludes with a future research agenda.