Pomegranate juice (PJ), Spirulina platensis extract (SP) and Echinacea purpurea Extract (EP) was chromatographically analyzed by High performance liquid chromatography (HPLC) for phenolic and flavonoid compound. Also, this extracts was determined for total phenolic content (TPC), total flavonoid content (TFC) and antioxidant activates in terms of scavenging DPPH free radicals. The TPC of (PJ) was 26.15mg gallic acid/g of extract, and TFC was 17.6 mg catechin/g of extract, while total phenolic content for (SP) and (EP) extracts were 0.153, 0.773mg gallic acid/ml, respectively. The total flavonoids content for each of them was 2.599, 8.063mg catechin/ml, respectively. Identification of phenolic compounds showed high amount of ellagic acid, pyrogallol, catechein, benzoic, cinnamic, syringic, gallic, aminobenzoic, protocatechuic, catechol, epicatechein, caffeine, P.OH.benzoic, caffeic, vanillic, p-Coumaric, Ferulic, -Coumaricand Salycilic. Also, identification of the flavonoids compounds appeared high amount of rutin, quercitrin, Hisperidin, Quercetrin, luteolin, kampferol, narengin and rosmarinic. Formulated pomegranates beverage (FPB) was also investigated for antioxidant activities and total phenolics content. Furthermore, phagocytosis inhibition test was carried out to measure immunomodulatory activity of pomegranate juice, stevioside, Spirulina, echinacea and formulated pomegranates beverage. Immunological tests showed highly significant increase in phagocytosis of macrophages for Formulated pomegranate beverage (FPB). Depending on sensory evaluation, the formulated pomegranates beverage showed overall acceptance compared to normal pomegranate juice. So, it could be concluded the suitability of pomegranate juice, spirulina, echinacea and stevioside as a supplementation in the production of health promoting beverage.