Eccrine Syringofibroadenoma Research Articles

Eccrine syringofibroadenoma with co‐existent squamous cell carcinoma

Eccrine syringofibroadenoma (ESFA) is a rare, benign adnexal tumor arising most often on the extremities of elderly individuals. It is typically a slow-growing, flesh- to reddish-colored nodule or plaque. Histologically, the tumor consists of anastomosing cords of cuboidal epithelial cells surrounded by a fibrovascular stroma containing plasma cells. The cords contain scattered ductal structures lined with cuboidal cells resembling eccrine ducts. The co-existence of ESFA with squamous cell carcinoma has been described, eliciting the term eccrine syringofibroadenoma. The differential diagnosis includes poroma, porocarcinoma, fibroepithelioma of Pinkus and clear cell acanthoma. ESFA stain positively with epithelial membrane antigen and carcinoembryonic antigen. Cytokeratin studies have been inconsistent.

Leprosy-associated eccrine syringofibroadenoma of Mascaro

Eccrine syringofibroadenoma of Mascaro is a rare benign tumour. There are five subtypes, one of which is known to occur in reaction to inflammatory and neoplastic dermatoses. We describe a patient with previous lepromatous leprosy presenting with multiple flesh-coloured verrucous plaques over the right foot. Histology was consistent with eccrine syringofibroadenoma. To our knowledge, this is the first reported case of multiple eccrine syringofibroadenomata occurring in association with leprosy. The tumours in this case are most likely reactive in nature, subsequent to multiple traumatic events with tissue remodelling in an insensate foot affected by leprosy. It is less probable that the tumours are a result of scarring from recurrent infections. We also raise the possibility of a neuroeccrine interaction, with sympathetic neuropathy in leprosy as a contributing factor in the pathogenesis.

Solitary eccrine syringofibroadenoma with prominent plasma cell infiltration

Eccrine syringofibroadenoma (ESFA) is a rare, benign, adnexal neoplasm thought to be eccrine ductal differentiation displaying variable clinical findings and characteristic histological features. It usually occurs as a solitary nodule on the extremities of an elderly person. Histological findings typically show a proliferation of anastomosing strands, cords, and columns of monomorphous epithelial cells that harbor eccrine duct formations embedded in a fibrovascular stroma. Acrosyringial nevus, though usually regarded as an identical lesion, is sometimes regarded as a different entity showing prominent plasma cell infiltration. We report two cases of solitary ESFA with prominent plasma cell infiltration. Clinicopathological features of both cases suggest that acrosyringeal nevus and ESFA may be of the same disease entity. Prominent plasma cell infiltration may be just one of the common histological features of ESFA.

Eccrine syringofibroadenoma

Eccrine syringofibroadenoma is a rare, benign, eccrine skin tumour with a propensity for the palms and soles. It has a variety of clinical presentations yet a characteristic histological appearance. We propose that in our case chronic venous stasis may have had an aetiological role. Complete removal or surveillance is advised for these tumours in view of a small risk of carcinomatous transformation.

A case of Schopf-Schulz-Passarge syndrome

Schöpf-Schulz-Passarge syndrome (SSPS) is a rare ectodermal dysplasia characterized by hypodontia, hypotrichosis, nail dystrophy, palmoplantar keratoderma, and periocular and eyelid margin apocrine hidrocystomas. Several other skin tumours have been described in association with this syndrome, in particular, multiple palmoplantar eccrine syringofibroadenoma (ESFA). We report a case of SSPS with diffuse palmoplantar hyperkeratosis, which was shown by histology and immunocytochemistry to be due to ESFA.

Eccrine Syringofibroadenoma of Clear Cell Variant

Eccrine syringofibroadenoma is a rare eccrine tumor first described by Mascaro in 1963. The clear cell variant was reported by Fretzin in 1995. We describe a hemorrhagic papule on the knee of a 64-year-old woman. Microscopic examination revealed epidermal-based anastomosing thin epithelial cords with ductal structures surrounded by a fibrovascular stroma. Multiple nests of glycogen-containing clear cells were also present. The tumor cells forming the epithelial cords expressed keratin. The eccrine ductal structures and clear cells additionally expressed gross cystic disease fluid protein-15 (GCDFP-15). Reactivity with antibodies against estrogen receptor or progesterone receptor was negative. These results favor the dual differentiation of the clear cell variant of eccrine syringofibroadenoma toward ductal and secretory portions of the eccrine sweat gland.

Eccrine syringofibroadenoma in a patient with a burn scar ulcer

Eccrine syringofibroadenoma in a patient with a burn scar ulcer

Porokeratotic eccrine ostial and dermal duct nevus: A case report and review of the literature

Hamartomas with eccrine differentiation are quite rare. There are 5 accepted classifications: eccrine nevus, eccrine-centered nevus, eccrine angiomatous hamartoma, eccrine syringofibroadenoma, and porokeratotic eccrine ostial and dermal duct nevus. The latter, PEODDN, typically presents as congenital keratotic papules and plaques located on the distal extremities. We report a classic case of PEODDN that was localized to the left hand since early childhood. The literature on this rare benign tumor is also reviewed. (J Am Acad Dermatol 2000;43:364-7.)

Porokeratotic eccrine ostial and dermal duct nevus: A case report and review of the literature

Hamartomas with eccrine differentiation are quite rare. There are 5 accepted classifications: eccrine nevus, eccrine-centered nevus, eccrine angiomatous hamartoma, eccrine syringofibroadenoma, and porokeratotic eccrine ostial and dermal duct nevus. The latter, PEODDN, typically presents as congenital keratotic papules and plaques located on the distal extremities. We report a classic case of PEODDN that was localized to the left hand since early childhood. The literature on this rare benign tumor is also reviewed. (J Am Acad Dermatol 2000;43:364-7.)

Eccrine syringofibroadenoma developing in a sebaceous naevus

Eccrine syringofibroadenoma developing in a sebaceous naevus

Reactive eccrine syringofibroadenoma: An association with chronic foot ulcer in a patient with diabetes mellitus

Eccrine syringofibroadenoma is a rare skin tumor with a variety of reported clinical manifestations. We report a case of reactive eccrine syringofibroadenoma associated with a chronic skin ulcer of the foot in a patient with diabetes mellitus.

Reactive eccrine syringofibroadenoma: An association with chronic foot ulcer in a patient with diabetes mellitus☆, ☆☆, ★

Reactive eccrine syringofibroadenoma: An association with chronic foot ulcer in a patient with diabetes mellitus☆, ☆☆, ★

Familial eccrine syringofibroadenomatosis with associated ophthalmologic abnormalities

Eccrine syringofibroadenoma (ESFA) is a rare benign adnexal tumor, generally with sporadic occurrence and not linked to other diseases. Only one familial occurrence of ESFA has been reported. We describe the familial occurrence of multiple ESFAs in a father and his two sons, all of whom also had similar eyelid abnormalities and progressive corneal scarring. This description of hereditary ESFA is the first to link ESFA with periocular and ocular abnormalities. (J Am Acad Dermatol 1998;39:356-8.)

Eccrine syringofibroadenomatosis associated with hidrotic ectodermal dysplasia

Eccrine syringofibroadenoma (ES) is generally regarded as a solitary benign adnexal neoplasm of the skin. Recently, the epithelial and stromal changes of this lesion have been recognized as being a reaction pattern in certain settings. We describe two individuals in whom this process was a manifestation of hidrotic ectodermal dysplasia. In both cases, the diagnosis had been missed for many years and the process had been thought to be a manifestation of an inflammatory dermatosis of the palms and soles. In both instances, other family members were found to be affected. Thus, ES may be manifested clinically as erythematous erosive plaques, especially of the palms and soles. It is important that clinicians be familiar with this disorder and be aware that it may exhibit unusual cutaneous manifestations.

Eccrine syringofibroadenoma: Multiple lesions representing a new cutaneous marker of the Schöpf syndrome, and solitary nonhereditary tumors

Background: Eccrine syringofibroadenoma (ESFA) is a rare eccrine tumor that has characteristic histopathologic features and variable clinical findings. Objective: Our purpose was to define the clinical and histopathologic features of ESFA, to assess a possible syndromic association and heredity, and to propose a clinicopathologic classification. Methods: Three solitary and five multiple cases of ESFA were analyzed and the findings compared with those of previously published cases. Results: Clinically, solitary ESFA was typically a nonhereditary verrucous growth. Multiple examples presented as palmoplantar bkeratoderma and keratotic papules in a mosaic pattern. In the multiple form, four patients had the Schöpf syndrome (hydrocystomas of the eyelids, hypotrichosis, hypodontia, and nail abnormalities); one had an incomplete form of the syndrome. Histologically, ESFA showed a reticulate proliferation of thin strands of acrosyringeal cells with focal lumen formation, and a fibrovascular stroma. Malignant ESFA was present in one multiple case. Conclusion: Multiple (palmoplantar) ESFAs are a new cutaneous marker of the Schöpf syndrome. (J Am Acad Dermatol 1997;36:569-76.)

Eccrine Syringofibroadenoma; A Clear-Cell Variant

Eccrine syringofibroadenoma (acrosyringeal nevus) is a rare tumor of proliferating ductular structures resembling the acral portion of the eccrine duct. Our case describes a histologic variant showing nests of periodic acid Schiff-positive clear cells resembling the clear-cell variant of eccrine syringoma.

Eccrine syringofibroadenoma. Report of a case and immunohistochemical study of keratin expression

We report a 49-year-old woman with an eccrine syringofibroadenoma. An asymptomatic nodule appeared on the right heel, and subsequently enlarged gradually. Histological examination revealed anastomosing strands of pale epithelial cells, with occasional duct formation and mucinous fibrovascular stroma. There were two types of strands: thick and thin. Immunohistochemical study, using a panel of monoclonal antikeratin antibodies, revealed that the immunoreactivity differed between the two types of strands. The thick strands showed a staining pattern similar to the uppermost portion of the intradermal duct, and the thin strands showed a pattern similar to the other portion of the duct. This observation suggests that the thick and thin strands differentiate towards the uppermost portion and the remainder of the duct, respectively.

Eccrine syringofibroadenomatosis (Mascaro) with mucous involvement

Eccrine syringofibroadenoma (ESFA) is a rare benign cutaneous lesion due to the proliferation of the eccrine acrosyringium. To our knowledge, mucous involvement has never been mentioned. We report a case of multifocal ESFA with plantar lesions and balanoposthitis. Report of a Case. A 30-year-old man was referred for involuting painful lesions of the soles. These lesions began 6 years earlier as a dishidrotic aspect of the left plantar arch, with progressive bilateralization. The medical history included recurrent uveitis, sinusitis, otitis media, and adult-onset insulin-dependent diabetes mellitus. Family history was free of similar symptoms. On physical examination, both soles exhibited pink-red elevated spongy plaques with punctate hyperkeratotic aspects and a well-demarcated border (Figure 1). A glossy erythematosus balanoposthitis with scattered whitish hyperkeratotic points was noted (Figure 2). There were no other manifestations despite hyperhidrosis of the palms and soles. Local treatment with 33% trichloroacetic acid and corticosteroids partially improved the symptoms.

Eccrine Syringofibroadenomatosis (Mascaro) With Mucous Involvement

Eccrine syringofibroadenoma (ESFA) is a rare benign cutaneous lesion due to the proliferation of the eccrine acrosyringium. To our knowledge, mucous involvement has never been mentioned. We report a case of multifocal ESFA with plantar lesions and balanoposthitis. <h3>Report of a Case.</h3> A 30-year-old man was referred for involuting painful lesions of the soles. These lesions began 6 years earlier as a dishidrotic aspect of the left plantar arch, with progressive bilateralization. The medical history included recurrent uveitis, sinusitis, otitis media, and adult-onset insulin-dependent diabetes mellitus. Family history was free of similar symptoms. On physical examination, both soles exhibited pink-red elevated spongy plaques with punctate hyperkeratotic aspects and a well-demarcated border (<b>Figure 1</b>). A glossy erythematosus balanoposthitis with scattered whitish hyperkeratotic points was noted (<b>Figure 2</b>). There were no other manifestations despite hyperhidrosis of the palms and soles. Local treatment with 33% trichloroacetic acid and corticosteroids partially improved the symptoms.

Filaggrin immunoreactive composite keratohyalin granules specific to acrosyringia and related tumours.

The luminal cell layer of acrosyringia contains heterogeneous globular keratohyalin granules, some of which contain basophilic and eosinophilic components. Using immunoelectron microscopy we found that the majority of the granules, which are basophilic, are strongly reactive to an anti-filaggrin antibody, while the minority, which are eosinophilic, are not. Similar heterogeneous keratohyalin granules were observed in syringomas and in an eccrine syringofibroadenoma. Since such granules are not normally observed in other human cutaneous epithelia, it is suggested that these composite keratohyalin granules with partial filaggrin immunoreactivity might serve as a useful marker for acrosyringial differentiation in both normal and pathological material.