Eccrine Syringofibroadenoma Research Articles

Reactive Eccrine Syringofibroadenoma in Association With an Atrophic Dermatofibroma.

Reactive Eccrine Syringofibroadenoma in Association With an Atrophic Dermatofibroma.

Siringofibroadenoma écrino em paciente tetraplégico por mielite transversa

Eccrine syringofibroadenoma (EFAS) is a rare benign tumor that originates from the eccrine sweat glands. It has a predilection for the extremities of elderly individuals and may arise in association with various acquired or hereditary diseases and neoplastic skin disorders. We report the case of a 48-year-old man who had been quadriplegic due to transverse myelitis for 30 years, with a rapidly progressive plantar tumor that was difficult to diagnose.

Reactive Eccrine Syringofibroadenoma (ESFA) in Association With a Merkel Cell Carcinoma Excision Scar.

Eccrine syringofibroadenoma (ESFA) is a rare benign skin adnexal lesion of the acrosyringium of eccrine sweat ducts. Reactive ESFA, a subtype of ESFA, is usually associated with non-neoplastic cutaneous dermatoses or neoplastic skin tumors. Clinically, the lesions can be solitary or multiple, pink, or skin-colored coalescing papules or nodules of variable sizes. Histopathologically, this tumor is composed of numerous anastomosing cords of monomorphic cuboidal epithelial cells with eccrine duct formation. The association of reactive ESFA with benign conditions, such as psoriasis, diabetic polyneuropathy, scars, and leprosy, has been reported. However, the association of reactive ESFA with malignant tumors is extremely rare, with very few cases reported in the literature. We present a case of a 72-year-old woman who developed reactive ESFA associated with Merkel cell carcinoma excision scar. The ESFA tumors developed in the area of the surgical graft 10 months after the Merkel cell carcinoma had been excised. New ESFA tumors have continued to appear in the scar on a yearly basis while, so far, has been no recurrence of the original tumor. However, the presence of new tumor growths in the area suggested the possibility of recurrence of the Merkel cell carcinoma. That possibility was enhanced by the fact that PET scans revealed hypermetabolic activity in the ESFA papules.

Reactive Eccrine Syringofibroadenoma: A Case Report

Eccrine syringofibroadenoma is a rare adnexal tumor of sweat glands, with different clinical presentations. It is mainly found at the extremities, but also occurs on the trunk, the nail pulp, or the eyelids. The microscopic examination shows anastomosing cords of cuboidal cells deriving from the epidermis, infiltrating the dermis and separated by a fibrovascular stroma.

Reactive eccrine syringofibroadenoma triggered by thermal damage: case report

Reactive eccrine syringofibroadenoma triggered by thermal damage: case report

Reactive Eccrine Syringofibroadenomatosis Associated With Venous Leg Ulcers: A Case Report and Literature Review.

Eccrine syringofibroadenoma (ESFA) is a rare adnexal tumor deriving from the acrosyringeal portion of the eccrine duct. Five subtypes of ESFA were described including a reactive form. Reactive ESFAs are associated with inflammatory and neoplastic dermatoses. In this article, we report the case of a 90-year-old woman presenting with 3 leg ulcers evolving for 2 years surrounded by large verrucous and eczematous lesions. Multiple skin biopsies showed anastomosing epithelial cords connected to the epidermis consistent with ESFA. We identified 8 cases of ESFA associated with chronic leg ulcers in the literature and reviewed their main clinical and histological features.

Solitary eccrine syringofibroadenoma of the dorsum of hand

Solitary eccrine syringofibroadenoma of the dorsum of hand

Syringofibroadenoma: Benign eccrine sweat gland tumor – A rare case report

Eccrine syringofibroadenoma (ESFA) is a rare adnexal tumor. It was first described by Mascaro in 1963. They are predominantly seen on the extremities of middle aged to elderly patients. Clinically, ESFA is classified into five subtypes. Solitary ESFA, the most common subtype, usually presents as a skin-colored papule, plaque, or nodule. The histomorphological and immunohistochemical features are necessary for their diagnosis and are also required to differentiate them from their malignant counterpart, eccrine syringofibrocarcinoma.

A Case of Multiple Eccrine Syringofibroadenoma with Palmoplantar Keratoderma

A Case of Multiple Eccrine Syringofibroadenoma with Palmoplantar Keratoderma

Commentary on Reactive Eccrine Syringofibroadenoma Associated With Basal Cell Carcinoma.

Commentary on Reactive Eccrine Syringofibroadenoma Associated With Basal Cell Carcinoma.

Syringofibroadenoma arising adjacent to verrucous carcinoma: Is it a reactive process, malignant transformation, or collision tumor?

Eccrine syringofibroadenoma (ESFA) is a rare, benign tumor showing acrosyringeal or sweat gland differentiation with variable clinical presentations, but distinct histopathological features. Rarely, ESFA coexists with a malignancy such as a squamous cell carcinoma or porocarcinoma. Herein, we report the first case of an ESFA associated with a verrucous carcinoma in a 46-year-old female on the right foot. It is unclear whether it represents a reactive process, a malignant transformation or a collision tumor. We recommend ESFA be completely excised if possible or closely followed given its association with a developing carcinoma.

Nodular Cystic Basal Cell Carcinoma of the Trunk: a Diagnostic Dilemma in an Unsuspecting Youth

Basal cell carcinoma (BCC) commonly affects the elderly and is mostly confined to the head and neck region. Only 10% of all cases occur on the trunk. We presented a case of bullous lesion on the abdomen in a young male, initially diagnosed by clinicians as a vascular nevus. Histopathological examination and immunohistochemistry (IHC) revealed it to be Nodular cystic variant of BCC. This rare variant of BCC morphologically resembles benign skin adnexal tumor of Eccrine syringofibroadenoma. Ber Ep4 positivity on IHC established the correct diagnosis. This case highlights that nodular cystic variant of BCC can be a diagnostic dilemma for clinicians and pathologists.

A case of eccrine syringofibroadenoma (ESFA) responding to electron beam radiation therapy

A case of eccrine syringofibroadenoma (ESFA) responding to electron beam radiation therapy

Perianal Eccrine Syringofibroadenoma.

Eccrine syringofibroadenoma (ESFA) is a rare eccrine ductal adnexal tumor. It shows variable presentations as solitary or multiple nodular lesions arranged in different patterns. It is most commonly seen in middle-aged to elderly patients, and most common sites include the extremities. Classic histopathological findings show anastomosing cords and strands of uniform cuboidal cells surrounded by fibrovascular stroma. Herein, we report a case of reactive ESFA which developed on the perianal region of a 31-year-old man.

Syringocystadenocarcinoma Papilliferum In Situ–Like Changes in Extramammary Paget Disease: A Report of 11 Cases

The authors report 11 cases of extramammary Paget disease (EMPD), all of which also demonstrated a combination of histological changes highly reminiscent of syringocystadenocarcinoma papilliferum in situ. In addition to the classical features of EMPD, characterized by the intraepidermal spread of individually dispersed neoplastic cells with ample cytoplasm, many of which contained mucin, there were areas of acanthosis with the substitution of spinous layer keratinocytes by neoplastic cells, whereas the native basal cell layer was intact. In addition to acanthosis (and sometimes papillomatosis), the dermal papillae showed a prominent infiltrate of plasma cells, completing the resemblance to syringocystadenocarcinoma papilliferum in situ; this similarity was further enhanced in 2 cases, which showed conspicuous gland formation. One additional case showed multifocal dermal proliferations compatible with eccrine syringofibroadenoma (syringofibroadenomatous hyperplasia). The changes described herein seem to be relatively rare in EMPD, and they can represent a diagnostic pitfall, as evidenced by 2 cases that were originally misinterpreted as syringocystadenocarcinoma papilliferum in situ. Clinically, these microscopic changes sometimes corresponded to nodular lesions, which were specifically noted to have a papillated erosive surface.

Solitary eccrine syringofibroadenoma: a case report showing papillary tubular adenoma-like features

Solitary eccrine syringofibroadenoma: a case report showing papillary tubular adenoma-like features

Reactive Solitary Eccrine Syringofibroadenoma: A Very Rare Adnexal Tumour of Skin

Eccrine syringofibroadenoma (ESFA) is a very rare benign tumour of intraepidermal part (acrosyringium) of eccrine sweat duct. Based on the evidence of known aetiological factors, two forms have been proposed: reactive ESFA and non-reactive ESFA. Rarely, non-reactive forms have been seen to be associated with ectodermal dysplasia. Reactive type has been considered as hyperplastic or hamartomatous response to many inflammatory and neoplastic dermatoses. Owing to its clinical similarity with other chronic dermatoses like deep mycoses, squamous cell carcinoma, diabetic foot ulcer or leprous neuropathic ulcer, it may remain misdiagnosed. Distinctive histopathological features with or without immunostaining usually confirm the diagnosis. ESFA is a very rare entity as to the best of my knowledge, only around 50 cases have been reported all over the world till date. Herein we report a case of reactive solitary ESFA on the right foot in a 65 years old male.

The story of a deformed leprous foot

Eccrine syringofibroadenoma (ESFA) is a rare adnexal tumour of eccrine ductal proliferation. A 50 year old treated case of leprosy presented with a chronic non healing ulcer of 5 years duration on the deformity laden right foot. Multiple verrucous papules and plaques were seen surrounding the ulcer which showed histopathological findings consistent with ESFA. Although ESFA constitutes a rare association with leprosy, considering the load of treated cases in our country and elsewhere, it may represent an under-reported entity which requires more attention in the post elimination era.

Eccrine syringofibroadenoma (ESFA): a report of two cases.

Eccrine syringofibroadenomas is typically a benign rare neoplasm. Eccrine syringofibroadenomas (ESFA) originates from or is differentiating toward the acrosyringium or eccrine dermal duct. Histologically, there are multiple anastomosing cords of benign epithelial cells surrounded by a loose fibrovascular stroma. The epithelial cords demonstrate ductal differentiation. Occasional luminal eccrine ducts are noted within the anastomosing cords. The authors describe two cases with different subtypes of ESFA, a solitary ESFA and a reactive ESFA with squamous cell carcinoma.

Reactive eccrine syringofibroadenoma in hyperkeratotic eczema.

Reactive eccrine syringofibroadenoma in hyperkeratotic eczema.