Traditional video conference systems depend largely on computational complexity to ensure system security, but with the development of high-performance computers, the existing encryption system will be seriously threatened. To solve this problem, a hybrid encryption scheme for quantum secure video conferencing combined with blockchain is proposed in this study. In the system solution architecture, first, the quantum key distribution network is embedded in the classic network; then, the “classical + quantum” hybrid encryption scheme is designed according to the secret level required for the video conference content. Besides, the real-time monitoring module of the quantum key distribution network is designed to ensure that users can check the running state of the network at any time. Meeting minutes can be shared by combining with blockchain. In order to quickly query meeting minutes, a cache-efficient query method based on B+ tree is proposed. The experimental results show that compared with the traditional video conference system, the quantum secure video conference system sufficiently integrates the technical advantages of the quantum key distribution to resist the security threats such as channel eavesdropping and high-performance computational attacks while ensuring the stable operation of the classic system, thus providing a video conference system with a higher security level. Meanwhile, the query time cost of blockchain with different lengths is tested, and the query efficiency of the proposed method is 3.15-times higher than the original query efficiency of blockchain.