One of the main problems hindering the development of territories adjacent to the state border of Eastern Russia is population outflow, mainly educated, young, and active citizens. Among the reasons are territorial differences in the level and quality of life. To analyze interregional differentiation, this study uses indicators of the dynamics of net incomes of legally employed citizens in various industries and sectors, adjusted for the rise in prices in the Russian regions. We considered the period from 2011, the moment of economic stabilization after the 2008–2009 crisis, up to 2016. Data are presented on changes in the legal incomes of citizens formed by regional economies in the period 2016–2018, when regional economic systems adapted somewhat to shocks after 2014. Official statistical information was processed and analyzed with GIS technologies; the results are presented in thematic maps of the distribution of the studied indicators by regions. The crisis-related phenomena and economic shocks undoubtedly had a significant impact on regional economies, but the degree of sensitivity to them, determined, inter alia, by socioeconomic policy, was highly heterogeneous. Import substitution policy has had a certain positive impact on the agricultural sector, and in most Russian regions, the net income of those working in it has grown significantly. Considering that the net incomes of citizens in the agroindustrial complex remain low, and the share of those living in rural settlements in eastern border regions is quite high, it should be stated that the geopolitical tasks in the Russia’s East are still far from solved. As a result of processing and analyzing a large body of data, it was established that the dynamics of net incomes of those employed in the Far Eastern economy is generally more favorable than in Eastern Siberia, although there are significant sectoral differences.