Eastern Origin Research Articles

A cultural exposition model for interpreting architectural heritage: A study on Pingyao historical city

Architectural heritage, encompassing both its material and immaterial aspects, serves as a vital lens for understanding the historical, social, and esthetic values embedded in a society. As a reflection of cultural evolution, it offers insight into the architectural technologies, social structures, and collective memories of specific historical periods. This article investigates the architectural history of Pingyao historical city by employing theoretical perspectives that integrate material, social, and spiritual dimensions. The study demonstrates how the philosophy and cultural values of ancient Chinese society are reflected in the spatial and architectural forms of Pingyao. The material dimension considers how principles such as Feng Shui, numerology, and color symbolism shaped the city’s general layout and building designs. The social attribute addresses the influence of Confucianism on spatial organization, the use of culturally significant architectural elements, and the function of key structures in fostering social unity among the population. The spiritual aspect explores concepts of Eastern origin, such as Yin and Yang, the Five Elements theory, and the “Unity of Heaven and Humanity,” as these are incorporated into the city’s external architecture. Furthermore, it examines the influence of Buddhism and Daoism on Pyingyao’s architectural features. This comprehensive analysis reveals that Pingyao is far more than a collection of historic buildings; it is an intricate cultural artifact, offering a unique perspective on earlier stages of Chinese thought and society. Therefore, the preservation and study of Pingyao’s architecture offer a valuable opportunity to deepen our understanding of China’s architectural history.

Seed morphometrics unravels the evolutionary history of grapevine in France.

The cultivation of grapevines has spanned millennia, leading to thousands of varieties through exchanges, mutations, and crosses between genotypes, as well probably as gene flow from wild populations. These varieties are typically categorized by regional origin and primary use, either for wine production or fruit consumption. France, within the Western European group, hosts many of the world's renowned wine grape varieties. However, the historical development of cultivated grapevines in France and in the world remains poorly understood. This study applies morphometry on 19,377 charred and waterlogged archaeological grape pips to investigate the evolutionary history of grapevine in France over the last 10,000 years. The study compares seed outlines and lengths, corrected for taphonomic distortions, with a reference collection of 80 wild and 466 modern domestic grapevine accessions. Findings reveal a shift from wild grapevine exploitation to the expansion of domestic varieties around 600-500 BCE, coinciding with Mediterranean cultural influences and the introduction of eastern grape types. The identification of the East-Table group, a group of varieties of eastern origin for fruit consumption, indicates that grapes were also grown for food, especially in Mediterranean regions and near urban areas, alongside wine production. Early French viticulture featured a notable presence of Western European wine-type grapevines. The abundance of pips with wild-like morphology suggests early cultivation involved plants at an initial domestication stage and gene flow between introduced and wild grapevines. As viticulture spread northward, wild and Eastern morphotypes declined, leading to the dominance of Western European wine types in inner France during the Middle Ages.

Heterogeneous effects of increased availability of alcohol on hospitalisation due to external causes. Quasi-experimental evidence from the introduction of Saturday opening at Swedish alcohol retail stores.

Responses to increased alcohol availability may vary across the population as a function of differential vulnerability. This study therefore aimed to examine the effects of the implementation of Saturday opening at the Swedish alcohol retail monopoly in 2000 on risks of hospitalisation due to external causes (HEC) among different population subgroups. Leveraging the experimental design of the reform, longitudinal difference-in-differences analyses were applied to a register-based cohort of individuals aged 20-40 at the time of implementation. The population was stratified into groups of Swedish, Finnish, and Middle Eastern origin, known to represent different levels of alcohol consumption and rates of alcohol-related morbidity. Results showed a 17.7% increase (p<0.029) in the risk of HEC among individuals of Finnish origin, as jointly caused by both increased prevalence in the experiment area and decreased prevalence in the control area. The increase was primarily driven by younger men with lower levels of education. Those of Swedish origin exhibited largely similar patterns (9.7% increase; p<0.001) while no measurable impact was observed among individuals of Middle Eastern origin (-21.4% decrease; p<0.076). The findings confirm that increasing alcohol availability contributes to the disease burden related to alcohol among population subgroups already susceptible to its effects.

&lt;i&gt;FADS&lt;/i&gt; gene polymorphism and the history of the formation of the indigenous populations of Siberia

The polymorphism of the rs174570, rs74771917, and rs7115739 FADS-gene loci in Siberian populations was studied. It was shown that the frequency of the rs174570-T variant marking haplotype A with a reduced level of fatty acid desaturase expression in the modern indigenous populations increases in the direction from the south to the north of Siberia. Similarly, an increase in the frequency of the TTT haplotype at the rs174570, rs74771917, and rs7115739 loci was observed in the northern direction. However, in ancient times, the populations of Eastern Siberia (its northeastern part, Baikal region, and Primorye) were characterized by an equally high frequency of the rs174570-T variant (over 80%). It was shown that the main influx of the rs174570-C allele (and the CCG haplotype) to northeast Siberia occurred relatively recently, over the past 300 years, as a result of mating contacts between indigenous populations and immigrant groups of predominantly eastern European origin. The gene flow intensity (for the rs174570-C allele) is estimated to be 1.5-4.4% per generation. The appearance of the rs174570-C variant in the population of the Baikal region has been registered since the Eneolithic epoch, which is apparently associated mainly with the advance of the Afanasievo culture tribes to the east of Siberia. Meanwhile, analysis of paleogenomic data showed that the TTT haplotype, with high frequency distributed in modern Eskimos and Amerindians, was present in the upper Paleolithic population of the Amur region, and therefore its carriers apparently took part in the formation of the ancient Beringian population.

Elemental analysis of glass artifacts from Sarethi (India): Examining possible evidence of glass craft in northeastern Uttar Pradesh

Fragments of glass bangles from the site of Sarethi in Uttar Pradesh, India were investigated using laser ablation – inductively coupled plasma – mass spectrometry. This site yielded glass artifacts dating from 200 BCE to 1500 CE but also some possible evidence of bangle making during the 200 BCE-300 CE period. Two main glass types were identified at the site, with only one sample with a possible Middle Eastern origin and all the other bangles manufactured from three different sub-types of Indian glass. Most of the tested samples belong to the recently discovered and still poorly documented glass group m-Na-Al 8. The other samples could be attributed to either the m-Na-Al 3 or m-Na-Al 4 glass types. We hypothesized that all these different m-Na-Al glasses were manufactured within the eastern Uttar Pradesh region where Sarethi is located although this will need further investigations. Vitreous artifacts of an uncertain nature were also analyzed to determine if they were connected to glass working at the site. These artifacts were certainly the results of the presence of sand close to a wood fire. Comparison of the results of Sarethi and Kopia, a site located 70 km away, indicates distinct glass patterns, suggesting their inclusion in different exchange networks despite their contemporaneity and proximity.

Copper for the early oxhide ingots traced to the South Urals

Oxhide ingots are flat, rectangular slabs of metal, most commonly of copper, with protruding corners of varying styles. These Late Bronze Age artifacts were widespread across the Mediterranean for approximately half a millennium between the 16th and 11th centuries BC. Although they are generally known as essentially a Cypriot “commodity brand” by the late 15th century BCE, the origin of this ingot’s distinct shape has remained unknown. With the expansion of the lead-isotope database of Eurasian copper ores, the origin of the oldest chemically characterized oxide ingots may now be defined. The bimodal lead isotope compositions of 15 early, pillow-shaped oxhide ingots excavated in Crete are consistent with those of copper ores from the Southern Urals, which are known to have been actively mined in the Bronze Age. Together, Pb isotope and trace element compositions indicate that the majority of the ingots were cast from copper derived from Ural-type Cu-Zn volcanogenic massive sulfide deposits. However, two ingots enriched in Ni, As, and Co match Main Ural Fault-type ores that are hosted by ultramafic rocks.The characteristic design of the pillow-shaped ingot was likely related to the particulars of overland transport, facilitating their long-distance conveyance on pack animals. There is further support of a non-Cypriot origin of this form in the possible association between the words for “ingot”, “copper” and “hide” across languages of Western Asia and the Mediterranean. Thus, an eastern origin of the oxhide form for ingots is likely.

Effects of an Invasive Bark Beetle Polygraphus proximus Blandf. Outbreak on Carbon Pool Dynamics in West Siberian Dark Coniferous Forests

Invasions of dendrophagous insects pose major threats to forest ecosystems and to the timber industry. The alien species bark beetle Polygraphus proximus Blandf. of Far Eastern origin has caused Siberian fir dieback in vast areas within several regions of Russia. Rapid spread of the pest and its outbreaks raise the issue of preserving the most important functions, including carbon sequestration, by the damaged forests. In this study, monitoring of carbon pool dynamics was carried out during 2012–2023 on four sample plots showing various degrees of damage in the southern taiga zone of Western Siberia in the Larinsky Landscape Reserve. Dynamics of the forest stands’ vitality were reflected in a rapid decline of the number of viable trees and an increase in amounts of deadwood, debris, and soil composition, resulting in a transformation of the natural biological carbon cycle in the native dark coniferous ecosystems.

Genetic analysis of Saker Falcon (Falcocherrug) subspecies.

Two subspecies of Saker Falcon are commonly accepted - Western (Falcocherrugcherrug) and Eastern (Falcocherrugmilvipes), which are differentiated by their distribution range and phenotype. In Bulgaria, Western Saker Falcons are breeding ex situ in the Wildlife Rehabilitation and Breeding Centre, part of Green Balkans - Stara Zagora NGO, with the aim of restoring the nesting population of the species in the country and both Western and Eastern - in the Breeding Centre for Birds of Prey in Burgas for the purpose of sale for the needs of falconry in the country and abroad. In 2021, a total of 115 birds from the two breeding centres were sampled. The samples were analysed in Bielefeld University (Germany) at nine microsatellite loci. Structure analyses were performed to establish the optimal explanatory number of groups. We compared the putative genetic groups with the known/expected origin of falcons. A separation in two groups best explained the allelic variation between samples. Out of 68 Saker Falcons with putatively Eastern origin, 66 were ascribed to genetic group 2 and two falcons had unclear, mixed or hybrid genetic fingerprints. Out of 42 Sakers with putatively Western origin, 33 were ascribed to genetic group 1, seven to genetic group 2 and two individuals appeared to have a mixed signature of genetic groups 1 and 2 with dominating alleles of group 2. Five known hybrids were scored as mixed signature with dominating genetic cluster 2. This suggests that the two (Eastern and Western) populations of Saker Falcon origin suggested by the subspecies' definitions are also adequate to be considered in breeding programmes. Genetic cluster 1 might represent the ancestral alleles shared with other falcons, while specific novel alleles allow the discrimination of secured Eastern Sakers (group 2), while these populations may be occasionally invaded by individuals from the west.

Evaluating Kaposi Sarcoma in Kidney Transplant Patients: A Systematic Review and Meta-Analysis.

Kaposi's sarcoma (KS) is a malignancy that commonly appears as lesions on the skin or mucosal surfaces but can also develop in other organs. This cancer is usually caused by the human herpesvirus 8 (HHV-8), recently known as Kaposi's sarcoma-associated herpesvirus (KSHV). KS is rare in the general population but can develop in kidney transplant recipients with varying incidence due to immunocompromised status from immunosuppression. The main aim of the present systematic review was to identify the prevalence and treatment of KS in kidney transplant patients. PubMed, Cochrane Library, and Google Scholar databases were searched for studies until October 2023. Full-text studies with similar research objectives were included, while non-English articles, reviews, case reports, ongoing clinical trials, and studies evaluating KS in HIV patients or after other solid organ transplants were excluded. All studies were observational; therefore, methodological quality was assessed using the Newcastle-Ottawa Scale. The statistical analyses were performed with the Comprehensive Meta-Analysis (CMA) software (Biostat, Inc.Englewood, NJ). The pooled analysis from the 15 studies includedshowed that KS develops in 1.5% of kidney transplant recipients and is more prevalent in African (1.7%) and Middle Eastern (1.7%) recipients than in Western recipients (0.07%). KS was also significantly more prevalent among male recipients than female recipients (OR: 2.36; p < 0.0001). Additionally, cyclosporine-based immunosuppression accounts for most KS incidences (79.6%) compared to azathioprine-based immunosuppression (28.2%). Furthermore, reduction or withdrawal of immunosuppression alone resulted in 47.8% KS complete remissions. Post-kidney transplantation KS is more frequent among males and patients of Middle Eastern and African origin. However, the gender difference may be attributed to most patients undergoing kidney transplants being male. Therefore, if gender balance is considered in future studies, then the difference might be insignificant. Based on our results, we can concur that the mainstay treatment for post-transplant KS is reduction or withdrawal of immunosuppression. However, the patients should be closely monitored to avoid KS recurrence and kidney rejection. Furthermore, there is an increased risk for KS with the use of cyclosporine-based immunosuppression. However, this does not mean that the withdrawal of this immunosuppression agent might result in improved KS outcomes because the withdrawal of azathioprine with or without cyclosporine reduction has also led to improved outcomes.

Predictors associated with symptoms of depression & anxiety during the COVID-19 among MENA immigrants in Houston, Texas

Very limited knowledge is available regarding the mental health of the immigrant population in the USA. We aim to assess the factors affecting the mental health of immigrants living in Houston from war-inflicted and stable countries of Middle Eastern and North African (MENA) origin during the pandemic. This cross-sectional study was conducted among the MENA immigrants using a validated survey of sociodemographic, general health, and COVID-19 questions. Multivariable logistic regression models assessed sociodemographic and clinical predictors of depression and anxiety. The outcome of interest was categorized as “moderate or severe” versus “minimal or mild” for depression and anxiety. Total of 94 participants completed the study, with the sample rate of "moderate or severe" symptoms of anxiety and depression being 29.78% and 64.89%, respectively. Multivariable regression analysis for depression showed that immigrants from war-inflicted countries of origin were less likely to report “moderate or severe” depression compared to immigrants from stable countries (OR = 0.082, 95% CI 0.012–0.551). Individuals with excellent overall health (OR = 0.074, 95% CI = 0.013–0.414) had a significantly lower likelihood of “moderate or severe” depression than those who reported fair/poor health. Non-smokers (OR = 0.068, 95% CI = 0.012–0.377) were less likely to report “moderate or severe” depression in comparison to those who engage in smoking behavior. Participants who responded to the question that they tried hard to avoid thoughts of COVID-19 were less likely to have symptoms of “moderate or severe” depression compared to participants who responded, “No” (OR = 0.110, 95% CI = 0.017–0.712). Those who have” excellent/good knowledge” (OR = 0.0146, 95% CI = 0.022–0.946) about the prevention of COVID-19 spread were less likely to have “moderate or severe” depression compared to those who had “average/poor/terrible”. Multivariable regression analysis revealed smoking as a significant predictor of anxiety, with non-smokers demonstrating a lower likelihood of experiencing "moderate or severe" anxiety than smokers (OR = 0.21, 95% CI = 0.06–0.84). MENA immigrant communities in the USA have diverse immigration experiences, cultural backgrounds, and instability issues in their home countries, possibly elevating the risk of depression and anxiety during the COVID-19 crisis. Predictors identified should be considered by policymakers when developing targeted interventions to ensure the mental and social well-being of immigrant communities in the USA.

«Смерть Лопатинского» Ф. Булгарина в переложениях финских авторов XIX в.

The article explores the Swedish translation and poetic adaptations of F. Bulgarin’s “war story” “The Death of Lopatinsky,” published in Finland at the turn of the 1830s and 1840s. The article documents and explains the differences between the Swedish translations and the original Russian work. It also notes the reaction of the Finnish readership to the Swedish texts. The response to the relatively accurate translation of Bulgarin’s story published in the newspaper “Wasa tidning” (January 1839) was an article in “Borgå tidning” (May 1839), containing a truthful, in contrast to the Russian version, description of the death of Lieutenant Lopatinsky in September 1808. The article discusses Janne Lundmark’s poem “The Death of Lopatinsky, and the Voices at the Tomb,” which was published in Helsingborg in 1843. This poem is a poetic reworking of Bulgarin’s text and includes references to several characters from Scandinavian mythology, with the Houris being the most prominent. The article suggests that Lundmark indicates the eastern origin of the hero of the poem in this way. The article also notes that Valkyries and Houris often form a pair of “maidens of Paradise” in Swedish literature from the first half of the 19th century. Lundmark probably takes this into account. Finally, the article mentions that Lundmark’s poem is one of several works by Swedish-speaking authors from the 17th–18th centuries that are dedicated to the death of a hero.

Серебряный карась Carassius gibelio (Bloch, 1782) в Чарвакском водохранилище Узбекистана: морфологическая и молекулярно-генетическая характеристика

Morphological variability in response to environmental features is an important feature of alien species, increasing their adaptive capabilities and facilitating naturalization in new habitats. The prussian carp Carassius gibelio is currently very widespread in the world. Much of its current range is believed to be acquired as a result of human activity, with the prussian carp recognized as an invasive species capable of having a significant impact on recipient ecosystems. On the territory of Uzbekistan, prussian carp has been known in the lower reaches of the Syr-Darya and Amu-Darya since the 4th millennium BC, and was also recorded in the first half of the 20th century. However, its numbers were not large. In the 1960s, the Amur form of the prussian carp was introduced into the water bodies of Uzbekistan, as a result of a targeted introduction from the "Savvino" fish farm near Moscow and the accidental import of herbivorous fish with juveniles from the Russian Far East, after which its unauthorized resettlement began with planting material of cultivated cyprinids. In the 1970s, prussian carp found their way into the Charvak Reservoir. This is a mountain cold-water reservoir, formed on the Chirchik River (the right tributary of the Syrdarya River) and is located between the spurs of the Western Tien-Shan. With an area of only 37 km, it has a volume of about 2 km and a depth of more than 50 m. The reservoir is characterized by summer drawdown of the water level used for irrigation in the river valley Chirchik. This causes an almost complete absence of vegetation in the water area of the reservoir. Despite the atypical conditions, the prussian carp formed a self-sustaining population. There is none below the reservoir dam to the middle reaches of the Chirchik River. Indicators of counting characteristics of prussian carp in reservoir are D III-IV 17-19; A II 5-6; 26-30 (average 29) scales in the lateral line; on the first gill arch, 40-53 (on average 48) gill rakers and generally correspond to the characteristics in this climatic zone. Indices of plastic characteristics, both in traditional morphological analysis (see Table 1) and in the analysis of morphometric distances according to the “truss protocol” assessment method (see Table 2), do not have pronounced differences from the indicators of prussian carp living in a lowland reservoir Tudakul and in the fish ponds of the fish hatchery of the Research Institute of Fisheries of Uzbekistan. Analysis of the nucleotide sequences of the cyt b gene of prussian carp from the Charvak reservoir showed their similarity with samples from the upper reaches of the Yangtze river, China (see Table 3), which proves Far Eastern origin of prussian carp ih the Charvak reservoir. It is likely that it was the prussian carp, brought from the Far East, that ensured the growth in the number of the species in Uzbekistan. The question of the breadth of distribution of the Amur form of prussian carp in the region and the preservation of its native form currently remains open and requires further research using molecular genetic methods. The article contains 2 Figures, 3 Tables and 30 References. The authors are grateful to the directorate of the Institute of Zoology of the Academy of Sciences of Uzbekistan for creating conditions for the implementation of the planned scope of work. The Authors declare no conflict of interest.

Inference on the biological history of the Comoros archipelago using the CD4 Alu/STR compound system

The Comoros Archipelago is located at the northern end of the Mozambique Channel between Madagascar and the East African coast. Its settlement would have been influenced by contacts and possibly migratory waves that would have come from the East African coast, Middle East and Southeast Asia. This finding was the conclusion of various previous genetic studies carried out on Comorian populations to answer the question of its settlement and its biological history. These studies have used many kinds of molecular markers, although the autosomal markers (Alu/STR CD4) used in the present study have never been studied on the archipelago's populations. Nevertheless, they have been used on populations all over the world and have provided valuable information on genetic affinities and differentiation between populations and have also shed more light on the origins of modern human.In this study, we aimed to characterize for the first time the populations of the 3 main islands of the Comoros Archipelago using the CD4 Alu/STR compound system. Due to its robustness, this system allowed us to include, in our comparative analyses, populations having shared a common history with Comoros islanders (through migrations, commercial relations, or others).Our results showed by island, peculiar frequencies of STR and Alu alleles, as well as haplotypic ones. Genetic diversity values at the allelic level, ranged between 0.798 and 0.836 for the STR, and between 0.254 and 0.327 for the Alu. The most frequent haplotypes were 85+, followed by 115+ and 120+ in all the three islands. Phylogenetic and comparative analyses highlighted that our populations exhibit more affinities with sub-Saharan populations especially the Kenyans. However some Middle Eastern signals are perceptible in Anjouan Islanders through 90+ and 110− haplotypes.Finally, the results obtained contribute to a further understanding of the biological history of the Comoros population and provide new insights into the gene flows such as haplotypes of Middle Eastern origin.

God Talk: Christians Talking with Muslims in Buddhist Thailand

Religions use language in particular ways to attribute honour to humans and divine beings. This leads to complications in communication within the one Thai language but across social boundaries, specifically between Christianity and Islam. These two religious movements of Middle Eastern origin have established a presence in Thai society and made different adaptations to the ways of talking, particularly about people of status or divinity. Language use is often a marker of social group membership. This presents challenges when the religious communities seek to talk to each other. After outlining the different hierarchical strata of the Thai language, I examine how the Christian tradition has adopted it to speak about God, human kings, and Jesus as a special case, and the different approach of Islam. The focal question of the paper is: How do the religious traditions speak to each other in ways that generate understanding and cooperation rather than rejection and division?

Diversity and Phylogeny of Gyrodactylus spp. (Monogenea: Gyrodactylidae) across the Strait of Gibraltar: Parasite Speciation and Historical Biogeography of West Mediterranean Cyprinid Hosts

Knowledge on the diversity of parasitic flatworms of Western Mediterranean cyprinids is extremely scarce. In the present study, we parasitologically investigated 12 cyprinid species across the Strait of Gibraltar inhabiting watersheds in northwest Africa (Morocco) and Iberia (Portugal and Spain). Taxonomically relevant features of the attachment organ and sequences of the 18S rDNA and ITS regions were used for species delineation and to investigate their phylogenetic relatedness. Among the Gyrodactylus collected from Morocco and Spain, we identified specimens with an unusual T-shaped dorsal bar observed herein for the first time. In contrast, the membranous patch-like structure surrounding the twisted inner roots of hamuli and the median ridge of the ventral bar have been generally observed in Eurasian relatives. Our analyses suggest vicariant speciation of Gyrodactylus across the Strait of Gibraltar. We describe herein G. gibraltarensis sp. nov. from Iberian Luciobarbus graellsii; G. moroccensis sp. nov. from northwest African cyprinids, i.e., L. maghrebensis, L. rabatensis, L. rifensis, L. yahyaouii, and L. zayanensis; and finally, G. pseudomoroccensis sp. nov. from Moroccan L. ksibi, all possessing a new haptoral configuration. The genetic divergence and conservative morphologies in populations of G. moroccensis sp. nov. from five cyprinid species support its ongoing speciation in Northwest Africa. The West Mediterranean lineage was revealed to be monophyletic, with Eurasian species forming a sister group. Morphologically, West Mediterranean Gyrodactylus also appeared to be of Middle Eastern origin. Gyrodactylus spp. possessing an unusual T-shaped dorsal bar have most likely speciated, allowing for the appearance of a haptoral morphology that is restricted to the region across the Strait of Gibraltar. To conclude, viviparous Gyrodactylus reflect parasite speciation across the Strait of Gibraltar and the historical biogeography of cyprinids in the West Mediterranean.

Moyamoya Syndrome in Children With Sickle Cell Disease in Saudi Arabia: A Single-Center Experience.

Background Sickle cell disease (SCD) is relatively common in Saudi Arabia. Its neurologic complications such as stroke and Moyamoya syndrome (MMS) can be severe and devastating. Such complicationscan be minimized by modern investigative tools such as transcranial Doppler (TCD) ultrasound, which is unavailable in many high-risk places. Our aim is to investigate the prevalence and characteristics of these complications in children with SCD in our center where TCD is not available. Methods We conducted a retrospective record review of children with SCD admitted to the pediatric ward andvisited the pediatric hematology outpatient clinic of King Fahad Military Medical Complex, Dhahran, Saudi Arabia, from January 2010 to December 2021. The target population was children aged sixmonths to 14years with SCD and a history of stroke or transient ischemic attacks (TIAs). Their magnetic resonance imaging/magnetic resonance angiography (MRI/MRA) of the brain radiographic features were reviewed. A descriptive analysis was used to summarize the demographic characteristics and clinical features of patients with and without MMS. Results Twenty-six children (out of 385 with sickle cell anemia, originating mainly from the southwestern and eastern provinces of Saudi Arabia) experienced an overt stroke with an overall prevalence of 6.7%. All patients with stroke were originally from the Southwestern province. Their genotype was SS, and the median age at the onset of the first stroke was six years (IQR: 5.5). The main presenting symptoms were seizures (57.7%), motor weakness (42.3%), headache (15.3%), cranial nerve palsies (11.5%), cognitive deficit (7.6%), and dysphasia (3.8%). The majority of strokes were ischemic (92.3%). MMS was detected in 61.5% and was seen at the onset of the first stroke in all patients with this MRA abnormality. Seven children with moyamoya (43.8%) had recurrent strokes. Conclusion In this study, the prevalence of overt stroke is 9% in children with SCD originating from the southwestern region of Saudi Arabia (26/286), and 61.5% of them (16/26) had MMS. It is absent in the children of Eastern origin (99 children). In places lacking TCD facilities, further studies are required to determine if MRA brain screenings of children with SCD may detect MMS before the onset of stroke and help startprotective therapy.

Theorizing the Relationship between UK Schools and Immigrant Parents of Eastern and Central European Origin: the Parents’ Perspective

Schools may be particularly challenged in the building of relationships with immigrant families because of a potentially heightened mutual lack of knowledge or understanding about the other party’s cultural norms (e.g. Crozier &amp; Davis, 2007). In the context of increased immigration from Eastern and Central European states, this study seeks to initiate the development of model of multi-cultural family-school interaction drawing on existing frameworks drawn from the fields of education, psychology and sociology. With the intention of establishing the nature of migrant parents’ constructions of their relationships with their children’s schools, we carried out in-depth, semi-structured interviews with 10 parents of school age children who had migrated to the UK from Eastern and Central Europe within the past 10 years. The key themes from the interviews indicated that the parents’ expectations of their children’s schooling appear to clash with those of the UK school system and that this is amplified by perceptions of poor communication, inadequate school-parent cooperation &amp; marginalisation. Through the use of existing theoretical frameworks it was established that there is potential for improved practice though development of a model though this must take account of the full contextual complexity of the relationships.

Clinical and molecular features in a cohort of Middle Eastern patients with epidermolysis bullosa.

Epidermolysis bullosa (EB) features skin and mucosal fragility due to pathogenic variants in genes encoding components of the cutaneous basement membrane. Based on the level of separation within the dermal-epidermal junction, EB is sub-classified into four major types including EB simplex (EBS), junctional EB (JEB), dystrophic EB (DEB), and Kindler EB (KEB) with 16 EB-associated genes reported to date. We ascertained a cohort of 151 EB patients of various Middle Eastern ethnic backgrounds. The cohort was comprised of EBS (64%, 97/151), DEB (21%, 31/151), JEB (12%, 18/151), and KEB (3%, 5/151). KRT14 and KRT5 variants were most common among EBS patients with 43% (42/97) and 46% (45/97) of EBS patients carrying mutations in either of these two genes, respectively. Truncal involvement was more common in KRT14-associated EBS as compared to EBS due to KRT5 mutations (p < .05). Mutations in COL17A1 and laminin 332-encoding genes were identified in 55% (10/18) and 45% (8/18) of JEB patients. Scarring alopecia, caries, and EB nevi were most common among JEB patients carrying COL17A1 mutations as compared to laminin 332-associated JEB (p < .05). Abnormal nails were evident in most DEB and JEB patients while poikiloderma was exclusively observed in KEB (p < .001). EB patients of Middle Eastern origin were found to feature specific phenotype-genotype correlations of relevance to the diagnosis and genetic counseling of patients in this region.

The composition and provenance of Late Bronze Age vitreous materials from Kefalonia, Greece

In this study, we present the results of the analysis of Late Bronze Age (LBA) vitreous materials from three cemeteries on the island of Kefalonia, Greece (Mazarakata, Metaxata, and Kokkolata-Menegata). A multianalytical approach (EPMA, LA-ICP-MS, MC-ICP-MS [Sr-Nd]) was used to determine the composition and provenance of a group of 14 glass beads, a glass fragment, and a faience bead, all dating to the 14th-11th centuries BCE. Most of the beads were produced using a plant ash alkali with one having a mixed alkali composition. Identification of the colorants revealed that the blue glasses were colored using Cu, Co-Cu, or Co. Cobaltiferous alum from the Western Desert of Egypt imparted the blue color to the cobalt containing glasses. Trace element and isotopic analysis showed that all the relief plaques were made using imported Egyptian glass. The isotopic signature of one relief plaque, a triple rosette motif unique to Kefalonia (K13-4), suggests that there may be greater geological variation among the currently identified LBA Egyptian silica and alkali sources or possibly the use of new raw material sources in the region. Silica and plant ashes from different regions were exploited for the manufacture of two beads of Near Eastern origin. One bead (M18-3) was made from an alkali derived from plants likely growing in river valleys in zones MP-1 (northern Iraq) or MP-3 (southern Iraq) and silica from zone MP-2 (deserts in western Iraq/eastern Syria). The other bead was unique in composition characterized by high chromium, silica from northern Iraq (zone MP-1 N), and plant ash from the desert (zone MP-2). Similarities to raw materials used to produce glass at Alalakh may tentatively suggest a similar origin. A Mycenaean Group B faience bead (Co-Cu blue) included in the study was manufactured with an alkali and a source of cobalt that did not come from the Western Desert. Further identification of the alkali type and the source of the raw materials for this faience bead was not possible but similarities were found to Group B beads from Psara and Mesara in Greece.

Tourist behaviour: The role of digital marketing and social media

Social media and its applications are a part of daily life in Turkey and the rest of the world. In 2022, about 80.7 % of Turkey's population (69.9 million people) spent an average of 8 h daily using the Internet, providing a significant opportunity to encourage and influence tourists' purchase intentions through social media. This study aims to determine the effects of digital marketing and social media on tourist behaviours in Turkey. This study proposes a comprehensive model for the antecedents of tourists' behavioural intentions in their destination selection that can be found in the tourist destination online content (TDOC). The quality and user-friendly accessibility of the online information provides essential clues that influence tourists' behavioural intentions (intention to visit the destination and eWOM). Tourists' level of satisfaction with their first destination visits and the digital marketing interaction channels through which they share their experiences may positively affect their repeat visits/other tourists' behavioural intentions. Therefore, this study investigates the mediator effect of satisfaction and digital marketing interactions on the behavioural intentions of tourists of Eastern origin during their destination selection. Data was collected from 264 structured questionnaires and analyzed using partial least squares structural equation (PLS-SEM) modelling. Findings show that tourists' TDOC perceptions directly affect their behavioural intentions and that tourist satisfaction has a mediator role in the relationship between tourists' TDOC perceptions and behavioural intentions. Also, the results show that satisfaction and digital marketing interactions are important determinants of the intention to visit a tourist destination and eWOM intentions. Understanding tourists' perspectives on destination choice is crucial for policy makers, businesses and marketers as it will help formulate appropriate strategies to increase destination visits. In this respect, it is recommended to develop strategies to encourage tourists to share their experiences and satisfaction levels through digital marketing channels by improving the quality of products and services. Finally, the population of this study is limited to Turkey, and future research can extend this study to countries with different cultures and make new contributions to the related literature.