The Tibetan Plateau comprises several allochthonous terranes/blocks originated from the northern margins of eastern Gondwana. Brachiopod faunas from different terranes were referred either to Gondwana province or Cathaysia province through the Late Palaeozoic. They are very important in studying the palaeobiogeography regarding the early development of the Palaeotethys Ocean. However, due to tectonic complexity and uneven research in fossil groups through time, the palaeobiogeographical connections and geodynamic history of these terranes in the Mississippian (early Carboniferous) remain ambiguous. In this study, the brachiopod dataset was compiled and reviewed at three critical intervals in the Mississippian (Tournaisian, early Viséan, and late Viséan), based on material from 13 sections in the Tibetan Plateau (the Himalaya, Lhasa, North Qiangtang, and Qamdo) and those from adjacent areas in the Qaidam terrane, Baoshan terrane, Kashmir, Alborz Mountains, and western Australia. We utilized a community detection approach from network theory that incorporates presence-absence patterns of brachiopod genera. The results demonstrated increasing provinciality and endemicity through Tournaisian-Viséan, and supported a trend for the North Qiangtang and Qamdo terranes from the transition zone in the Tournaisian and early Viséan to a station far from the northern Gondwana margins since the late Viséan. This evidence further proves that the Longmu Co-Shuanghu suture zone serves as an effective palaeobiogeographic barrier and represents the main branch of the Palaeotethys Ocean during the Mississippian. The remarkable palaeogeographical reconfiguration represented by the significant palaeobiogeographical fragmentation appropriately indicates a moderate to low palaeolatitude for the North Qiangtang and Qamdo terranes regarding a persistently widening eastern Palaeotethys Ocean in the late Viséan.